An interventional study of Isokinetic Training and Plyometrics Training in Anterior Cruciate Ligament Reconstruction (ACLR), Anterior Cruciate Ligament Reconstruction Rehabilitation and Anterior Cruciate Ligament/Surgery, sponsored by Cairo University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
The primary goal of this RCT is to evaluate the effects of isokinetic training compared to plyometric training in patients aged 18-40 years who have undergone ACLR surgery.
The primary question to answer is which of the two interventions (isokinetic or plyometrics) has superior effect in the improvement of muscular strength, functional performance and patient-reported outcomes in ACLR patients.
Participants will be divided into two groups. Both groups received standard rehabilitation for 16 weeks, followed by adding for 8 weeks: Group 1: receives isokinetic training, Group 2: receives plyometric training (total=24 weeks).
Isokinetic and plyometric training represent two distinct approaches used in ACLR rehabilitation. Based on evidence, both showed significant improvements when performed postoperatively. However, there is no randomized controlled trial that has directly compared their effects on the comprehensive outcomes required for RTS clearance.
This study hypothesizes that both interventions will improve muscular strength, functional performance and patient related outcomes, with no significance of one over the other.
Cairo University is the lead sponsor of 4,909 studies on the registry; 1,445 are open to participants now.
Of its 37 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
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Exclusion Criteria:
The subjects will receive Isokinetic Training added to the standard rehabilitation program.
Other: Isokinetic Training
The subjects will receive Plyometrics Training added to the standard rehabilitation program.
Other: Plyometrics Training
Participants will receive standard therapy for 16 weeks, followed by an additional 8 weeks of isokinetic training alongside with standard therapy.
Participants will receive standard therapy for 16 weeks, followed by an additional 8 weeks of plyometric training alongside with standard therapy.
Isokinetic Quadriceps & Hamstring Peak Torques Normalized to Body Weight
The peak torques of quadriceps and hamstring are considered as the highest peak torque along the 5 repetitions at velocity 60°/s. Each is then normalized to body mass by the following equation: PTrelative = Peak Torque (Nm) / Body Mass (kg).
Time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).
Isokinetic Limb Symmetry Index (ISOK-LSI) of Quadriceps & Hamstring
ISOK-LSI is calculated by the following equation: ISOK-LSI = (involved limb PT / uninvolved limb PT) × 100. An LSI \>90% is commonly used as a criterion for adequate interlimb symmetry following ACL reconstruction.
Time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).
Hamstring - Quadriceps Ratio (H/Q)
H/Q is calculated by the following equation: H/Q = (hamstring PT/quadriceps PT) × 100. The hamstring-to-quadriceps (H/Q) ratio was calculated as the ratio of hamstring peak torque to quadriceps peak torque, expressed as a percentage. H/Q ratio of approximately 66.7% at 60°/s has been suggested as a reference value.
Time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).
Functional Performance test
For the distance tests (single-leg, triple ho, crossover hop), the longest distance (cm) is the best and is measured in centimeters using calibrated floor markings. For the time related test (6-meter timed hop), the shortest time (s) is considered and is measured using a digital stopwatch. For all four hop tests, 3 trials will be performed. The best trial will be taken to statistical analysis.
Time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).
Visual Analog Scale (VAS)
VAS is a subjective tool designed to assess the intensity of pain by providing quantitative measures of self-reported severity of symptoms. Ranges are: 0-3 indicates mild pain, 4-6 moderate pain, and 7-10 severe pain.
Time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).
Knee Injury and Osteoarthritis Outcome Score (KOOS)
KOOS is a subjective tool designed to measure the patients' opinion about their knee function and problems related to injuries that may lead to osteoarthritis including ACL, meniscal or chondral injuries. It is composed of 5 domains: 1) Symptoms, 2) Stiffness, 3) Pain, 4) Function - daily living, and 5) Function - sports and recreational activities, of total 42 items. The sum of all 5 dimensions represents the total score that is then transformed to a 0-100 score (%), where 0 indicates "extreme knee problem" and 100 indicates "no knee problems".
Time frame: Baseline (week 16), post-intervention (week 24) and follow up (week 32).
Plan to share: No
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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