Evaluation of the Mouthwash Effect on Maintaining Healthy Microbiome in Healthy Mouth.

1. Healthy female and male subjects (without any specific repartition) subjects
2. Subjects of Caucasian ethnicity
3. Subjects aged between 18 and 55 years (extremes included)
4. Subjects with a (resting, not stimulated) salivary pH in the range 6.0-7.0
5. Subjects with baseline plaque index PCR ≥ 30% of surfaces with plaque according to O'Leary*
6. Subjects with ≥ 20 natural teeth and regular consumption of dietary sugars, including soft drinks, fruit juices, and other sugar-rich foods or beverages.
7. Subjects registered with the national public health system in the country where the study is conducted
8. Subjects certifying the truthfulness of the personal data disclosed to the Principal Investigator or designated personnel
9. Subjects able to understand the language used in the investigation centre and the information given by the Principal Investigator or designated personnel
10. Subjects able to respect the instructions given by the Principal Investigator or designated personnel as well as able to respect the study constraints and specific requirements
11. Subjects who commit not to change their daily routine or lifestyle during the study
12. Subjects on stable pharmacological therapy (except for the pharmacological therapy in the non-inclusion criteria) for at least one month without any changes expected or planned during the study
13. Subjects informed about the test procedures who have signed a consent form and privacy agreement

Exclusion Criteria:

1. Subjects who do not meet the inclusion criteria
2. Subjects with active dental caries
3. Subjects with acute or chronic diseases (e.g. diabetes) able to interfere with the outcome of the study or that are considered dangerous for the subject or incompatible with the study requirements;
4. Subjects participating or planning to participate in other clinical trials
5. Subjects deprived of freedom by administrative or legal decision or under guardianship
6. Subjects not able to be contacted in case of emergency
7. Subjects admitted to a health or social facility
8. Subjects planning a hospitalisation during the study
9. Subjects who participated in a similar study without respecting an adequate washout period (at least one month)
10. Subjects under pharmacological treatments that are considered incompatible (e.g. antibiotics use 3 months before the study start) with the study requirement by the investigator
11. Subjects having a skin disease or condition liable to interfere with the study data or considered by the Investigator hazardous for the subject or incompatible with the study requirements
12. Subjects that have shown allergies or sensitivity to cosmetic products, drugs, patch or medical devices
13. Subject breastfeeding, pregnant or not willing to take necessary precautions to avoid pregnancy during the study (for the women of childbearing potential).
14. Subjects who are unwilling to use only the oral health and hygiene products provided as part of the study.