An interventional study of Active Sexual Health Product 1 and Active Sexual Health Product 2 in Sexual Desire, sponsored by Radicle Science. Not yet recruiting at 1 site in United States. Open to female participants aged 21 Years to 105 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Radicle Science · Not applicable, Interventional, and Other
Radicle Women's Sexual Health™ CIX: A randomized, double-blind, placebo-controlled direct-to-consumer study assessing the impact of health and wellness products on sexual health and related health outcomes.
This is a randomized, double-blind, placebo-controlled study conducted with adult participants, residing in the United States. Eligible participants are (1) female, (2) experience issues with sexual desire, (3) have the opportunity for meaningful improvement (at least 30%) in their primary health outcome, and (2) express acceptance in taking a product and not knowing its formulation until the end of the study. Participants that report a known contraindication or with well established, significant safety concerns due to illness will be excluded. Heavy drinkers and those who report they are pregnant, trying to become pregnant, or breastfeeding will be excluded. Participants that report taking medications with a known contraindication or with well-established, significant safety concerns will be excluded. Self-reported data are collected electronically from eligible participants for 13 weeks. Participant reports of health indicators will be collected at enrollment and throughout the active period of study product usage. All study assessments will be electronic; there are no in-person visits or assessments for this real-world evidence study.
Radicle Science is the lead sponsor of 66 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Participants must meet all the following criteria:
Adults, at least 21 years of age at the time of electronic consent, inclusive of all ethnicities, races, and gender identities
3.2 Exclusion
Individuals who report any of the following during screening may be excluded from participation:
Reports a diagnosis of cardiac dysfunction, liver or kidney disease that presents a known and/or a significant safety risk with any of the study product ingredients.
Reports taking medications that have a well-established moderate or severe interaction, posing a substantial safety risk with any of the study product ingredients.
Participants residing in the states of New York, New Jersey, or Rhode Island are eligible to enroll in the main study and will complete all primary study activities. However, these participants are not eligible to participate in the biomarker collection. This restriction is due to state regulatory requirements governing direct-to-consumer at-home laboratory specimen collection and processing that cannot be accommodated within the fully decentralized design of the biomarker collection. No alternative collection pathway is available under the current protocol.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
NYHA class (heart failure)
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Active Sexual Health Product 1
Dietary Supplement: Active Sexual Health Product 1
Active Sexual Health Product 2
Dietary Supplement: Active Sexual Health Product 2
Active Sexual Health Product 1
Dietary Supplement: Active Sexual Health Product 3
Placebo Sexual Health Control Product
Dietary Supplement: Placebo Sexual Health Control Product
Participants will use their Active Sexual Health Product 1 as directed for a period of 12 weeks
Participants will use their Active Sexual Health Product 2 as directed for a period of 12 weeks
Participants will use their Active Sexual Health Product 3 as directed for a period of 12 weeks
Participants will use their Placebo Sexual Health Control Product as directed for a period of 12 weeks
Sexual Desire
Sexual desire assessed by a single self report item, indicating sexual desire in the past 7 days. Scale 1-7 with higher scores indication greater desire.
Time frame: 13 weeks
Sexual activity frequency
Sexual activity frequency assessed by a single self-report item, indicating frequency of sexual activity in the last 7 days. Numerical text box entry, with higher scores indicating greater frequency of sexual activity.
Time frame: 13 weeks
Sexual discomfort intensity
Sexual discomfort intensity assessed by a single self-report item, indicating the intensity of discomfort during sexual activity in the past 7 days. Scale 1-7, with higher scores indicating greater sexual discomfort.
Time frame: 13 weeks
Change in feelings of stress
Change in feelings of stress: Difference between rates of change over time in feelings of stress score as assessed Perceived Stress Scale 10 (PSS-10) (score 10-50; where lower scores correspond to less stress)
Time frame: 13 weeks
Change in sleep-related impairment
Change in sleep-related impairment: Difference between rates of change over time in sleep score as assessed by PROMIS Sleep-Related Impairment 8a (score 8-40; where the higher scores correspond to worse sleep)
Time frame: 13 weeks
Change in mood (emotional distress-depression)
Change in mood (emotional distress-depression): Difference in rates of change over time in emotional distress score as assessed by PROMIS Emotional Distress- Depression 8A (score 8-40; with higher scores corresponding to greater levels of emotional distress)
Time frame: 13 weeks
Minimal clinically important difference (MCID) in mood (emotional distress-depression)
Minimal clinically important difference (MCID) in mood (emotional distress-depression): Likelihood of experiencing minimal clinically important difference in mood score as assessed by PROMIS Emotional Distress- Depression 8A (score 8-40; with higher scores corresponding to greater levels of emotional distress)
Time frame: 13 weeks
Minimal clinically important difference (MCID) in sleep
Minimal clinically important difference (MCID) in sleep: Likelihood of experiencing minimal clinically important difference in sleep score, as measured by PROMIS Sleep-Related Impairment 8a (score 8-40; where the higher scores correspond to worse sleep)
Time frame: 13 weeks
Minimal clinically important difference (MCID) in feelings of stress
Minimal clinically important difference (MCID) in feelings of stress: Likelihood of experiencing minimal clinically important difference in feelings of stress as assessed by Perceived Stress Scale (PSS-10) (score 10-50; where lower scores correspond to less stress)
Time frame: 13 weeks
Minimal clinically important difference (MCID) in sexual desire
Minimal clinically important difference (MCID) in sexual desire: Likelihood of experiencing minimal clinically important difference in sexual desire score as assessed by single self report item Sexual Desire (scale 1-7; where higher scores correspond to greater sexual desire)
Time frame: 13 weeks
Minimal clinically important difference (MCID) in sexual activity frequency
Minimal clinically important difference (MCID) in sexual activity frequency: Likelihood of experiencing minimal clinically important difference in frequency of sexual activity as assessed by single self report item sexual activity (numerical; where higher scores correspond to higher sexual activity)
Time frame: 13 weeks
Minimal clinically important difference (MCID) in sexual discomfort intensity
Minimal clinically important difference (MCID) in sexual discomfort intensity: Likelihood of experiencing minimal clinically important difference in intensity of sexual discomfort as assessed by single self report item sexual discomfort (scale 1-7; where higher scores correspond to greater sexual discomfort)
Time frame: 13 weeks
Plan to share: No — Data will not be shared with researchers outside of Radicle Collaborators on this study.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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