An interventional study of Conventional Ventilation and Lung-Protective Ventilation in Postoperative Pulmonary Complications (PPCs) and Atelectasis, sponsored by University Medical Center Ho Chi Minh City (UMC). Enrolling by invitation at 1 site in Vietnam. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-09-16.
Sponsored by University Medical Center Ho Chi Minh City (UMC) · Not applicable, Interventional, and Prevention
The goal of this clinical trial is to learn if lung-protective ventilation can improve perioperative oxygenation and reduce postoperative pulmonary complications in patients undergoing elective laparoscopic gastrectomy. The main questions it aims to answer are:
Researchers will compare lung-protective ventilation to conventional ventilation to see if the protective strategy safely mitigates atelectasis and improves oxygenation during surgery. Participants will:
377 studies on the registry are indexed under Pulmonary Atelectasis; 93 are open to participants now.
This study's planned enrollment of 102 is above the median of 60 across 268 interventional studies indexed under Pulmonary Atelectasis.
Browse Pulmonary Atelectasis studies →University Medical Center Ho Chi Minh City (UMC) is the lead sponsor of 34 studies on the registry; 19 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Procedure: Conventional Ventilation
Procedure: Lung-Protective Ventilation
Patients in this group will receive conventional intraoperative mechanical ventilation during surgery. The ventilator settings include a tidal volume (VT) of 8 ml/kg based on predicted body weight (PBW) and a positive end-expiratory pressure (PEEP) of 5 cmH2O.
Patients assigned to the lung-protective ventilation arm will receive a standardized intraoperative strategy using Volume-Controlled Ventilation (VCV) with a tidal volume of 6 ml/kg based on predicted body weight, a respiratory rate of 12 breaths per minute, an I:E ratio of 1:2, and an inspiratory pause greater than 0.2 seconds to minimize resistance for compliance calculations. Following an initial alveolar recruitment maneuver, a decremental PEEP titration will be performed by starting at 14 cmH2O and decreasing by 2 cmH2O every 4 minutes down to a minimum of 6 cmH2O to identify and maintain the optimal PEEP level, which is defined as the point of highest dynamic lung compliance. Furthermore, automated alveolar recruitment maneuvers applying a sustained pressure of 40 cmH2O for 15 seconds will be systematically executed immediately after endotracheal intubation, repeated every 30 minutes throughout the surgical procedure, and performed a final time immediately before extubation.
Intraoperative and Postoperative Gas Exchange (PaO2/FiO2 Ratio)
The ratio of arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FiO2). This index is used to evaluate the efficiency of pulmonary gas exchange and oxygenation status. PaO2 values are obtained from arterial blood gas (ABG) analysis. A higher ratio indicates better oxygenation.
Time frame: Assessed at 4 specific time points: T1: Baseline (before induction of anesthesia). T2: 1 hour after the start of CO2 pneumoperitoneum. T3: 30 minutes after tracheal extubation. T4: Postoperative day 1 (approximately 24 hours after surgery).
Peak Inspiratory Pressure (Ppeak)
The study will evaluate pulmonary mechanics by measuring the peak inspiratory pressure (Ppeak).
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Driving Pressure (Pdriving)
The study will evaluate pulmonary mechanics by measuring the driving pressure (Pdriving).
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Plateau Pressure (Pplat)
The study will evaluate pulmonary mechanics by measuring the plateau pressure (Pplat).
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Dynamic Lung Compliance (Cdyn)
The study will evaluate pulmonary mechanics by measuring the dynamic lung compliance (Cdyn).
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Static Lung Compliance (Cstat)
The study will evaluate pulmonary mechanics by measuring the static lung compliance (Cstat).
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Intraoperative Mean Arterial Pressure
Hemodynamic stability will be evaluated by measuring the mean arterial pressure (MAP).
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Intraoperative Heart Rate
Hemodynamic stability will be evaluated by measuring the heart rate.
Time frame: Assessed intraoperatively (recorded at post-intubation, 30 minutes after CO2 insufflation, every hour during CO2 insufflation, 10 minutes after CO2 exsufflation, and before extubation).
Incidence of Intraoperative Hypotension and Vasopressor Use
The study will record the number of participants experiencing intraoperative hypotension, defined as mean arterial pressure \< 65 mmHg or systolic blood pressure \< 90 mmHg, and the number of participants requiring vasopressors (ephedrine or phenylephrine).
Time frame: During the anesthesia and surgical procedure.
Incidence of Postoperative Pulmonary Complications
The study will record the number of participants experiencing specific postoperative pulmonary complications, including atelectasis, pneumothorax, pneumonia, and acute respiratory distress syndrome (ARDS).
Time frame: Atelectasis and pneumothorax assessed on postoperative day 1; pneumonia and ARDS assessed within 7 days after surgery.
Incidence of Intensive Care Unit (ICU) Admission
The study will record the number of participants requiring transfer to the intensive care unit from the post-anesthesia care unit due to respiratory complications.
Time frame: Up to 7 days postoperatively
Length of Hospital Stay
The study will evaluate the length of hospital stay, calculated from the date of surgery to the date of hospital discharge.
Time frame: From the date of surgery until hospital discharge, assessed up to 30 days.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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University Medical Center Ho Chi Minh City (UMC)