ClinicalTrials.gg
Not yet recruitingNCT07818785VECTORSUpdated Sep 14, 2026

The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial

An interventional study of defibrillator electrode pads in Cardiac Arrest (CA), sponsored by Oregon Health and Science University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-14.

Sponsored by Oregon Health and Science University · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
1,500
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
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Study summary

The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front and side of the chest (anterior-lateral [AL]), for the treatment of cardiac arrest. Both pad placement locations are recommended for use by the American Heart Association (AHA) and International Liaison Committee on Resuscitation (ILCOR) and are used in standard treatment. The investigators are hoping to find out if one pad position is more effective than the other in the treatment of cardiac arrest.

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Conditions studied

  • Cardiac Arrest (CA)

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03

In context

Heart Arrest

926 studies on the registry are indexed under Heart Arrest; 226 are open to participants now.

This study's planned enrollment of 1,500 is above the median of 100 across 518 interventional studies indexed under Heart Arrest.

Browse Heart Arrest studies →

Lead sponsor

Oregon Health and Science University is the lead sponsor of 696 studies on the registry; 131 are open to participants now.

Of its 52 completed or terminated interventional studies of FDA-regulated products, 39 (75%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest

Exclusion criteria

Exclusion Criteria:

  • ROSC at EMS arrival (e.g., bystander AED shock with ROSC prior to EMS care) without rearrest during EMS care
  • Known prisoners
  • Known pregnant patients
  • Known pediatric patients (treated under the pediatric algorithm, generally \<15 years)
  • Known preexisting do-not-resuscitate orders limiting care
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
1,500 participants (estimated)

Study arms

  • Active comparator
    Anterior-Posterior

    Defibrillation pads placed initially in the anterior-posterior position.

    Device: defibrillator electrode pads

  • Active comparator
    Anterior-Lateral

    Defibrillation pads placed initially in the anterior-lateral position.

    Device: defibrillator electrode pads

Interventions

  • Devicedefibrillator electrode pads

    Application of defibrillator electrode pads to be used in cardiac arrest treatment

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What researchers measure

Primary outcomes

  1. Post-Shock Return of Spontaneous Circulation (ROSC)

    Any palpable pulse documented at any time after the first EMS shock

    Time frame: day 1

Secondary outcomes

  1. Time to first rhythm analysis

    Time from EMS arrival on-scene for non-EMS witnessed arrests and first rhythm analysis by the defibrillator

    Time frame: day 1

  2. Time to initial shock

    Time from EMS arrival on-scene for non-EMS witnessed arrests and initial shock by EMS

    Time frame: day 1

  3. Total EMS shocks

    Total shocks given by EMS

    Time frame: day 1

  4. Time to ROSC

    Time to ROSC from initial shock with competing risks (e.g. termination of resuscitation, pad change, double sequential external defibrillation use)

    Time frame: day 1

  5. Survival to hospital admission

    Survival to hospital admission

    Time frame: day 1

  6. Survival to hospital discharge

    Survival to hospital discharge

    Time frame: through study completion, an average of 7 days

  7. Survival to hospital discharge with favorable outcome

    Survival to hospital discharge with a Cerebral Performance Category score of 1-2

    Time frame: through study completion, an average of 7 days

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Study locations

No study locations are listed for this record.

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References and documents

Individual participant data

Plan to share: Yes — A de-identified dataset will be shared with all data elements required for analysis.

Supporting information: Study protocol, Statistical analysis plan

Time frame: Within 12 months from study completion. No end date.

Access criteria: Stored in dataverse via request and data use agreement process

No publications or documents are linked to this record.

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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Apr 2027; primary completion for Jun 2029, 26 months later.

Of 204 non-industry interventional studies with no phase under Heart Arrest, half reached primary completion within 29 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 47. This study's planned 26 months is below that.

Counting every sponsor, half of 218 studies reached it within 28 months; a quarter within 10 and three quarters within 47.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 4, 2026
First posted
Sep 14, 2026
StartEst.
Apr 1, 2027
Primary completionEst.
Jun 30, 2029
CompletionEst.
Dec 31, 2029
Last update
Sep 14, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Sep 14, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07818785
Responsible party
Joshua Lupton (Principal Investigator, Oregon Health and Science University) — Principal investigator
First posted
Sep 14, 2026
Start date
Apr 1, 2027 (estimated)
Primary completion
Jun 30, 2029 (estimated)
Completion
Dec 31, 2029 (estimated)
Last update
Sep 14, 2026

Study contacts

Joshua Lupton, MD, MPH
Contact
lupton@ohsu.edu
503-418-6706

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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