An interventional study of Yoga-CaRe HF and Health Education in Heart Failure With Reduced Ejection Fraction, Heart Failure NYHA Class II and Heart Failure NYHA Class III, sponsored by Centre for Chronic Disease Control, India. Recruiting at 16 sites in India. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-14.
Sponsored by Centre for Chronic Disease Control, India · Not applicable, Interventional, and Treatment
The clinical study compares the benefits of yoga based rehabilitation programme versus an educational package during recovery of patients with heart failure. Cardiac rehabilitation programmes help patients with cardiac illness to return as quickly as possible to full and productive life and to reduce the chances of further cardiac illness or death. We want to know whether our package of yoga classes can provide effective cardiac rehabilitation and how that compares with a package of educational classes. Both packages are especially designed by us to improve heart health
6,331 studies on the registry are indexed under Heart Failure; 1,396 are open to participants now.
This study's planned enrollment of 3,500 is above the median of 76 across 4,049 interventional studies indexed under Heart Failure.
Browse Heart Failure studies →Centre for Chronic Disease Control, India is the lead sponsor of 9 studies on the registry; 2 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
LVEF (left ventricular ejection fraction)
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
NYHA class (heart failure)
The New York Heart Association’s four classes of how much heart failure limits physical activity.
Studies set their own limit — many outside heart failure leave out class III–IV, while heart failure studies may ask for a particular class. Check the class this study names.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Yoga based cardiac rehabilitation programme delivered as 20 sessions spread over three months and long term care and follow-up.
Behavioral: Yoga-CaRe HF · Behavioral: Health Education
Enhanced standard care comprising of health education delivered in 3 sessions spread over three months.
Behavioral: Health Education
A cardiac rehabilitation programme comprising of health education and yogic practices.
Health education on "Healthy Living with Heart Failure"
Major Adverse Cardiovascular event
Time to first cardiovascular event
Time frame: Median follow-up of 1 year
Heart Failure Specific Quality of life
Change in the Minnesota Living with Heart Failure Questionnaire (MLHFQ) total score from baseline. The MLHFQ consists of 21 items, each scored from 0 (no impact) to 5 (very much impacted), with a total score ranging from 0 to 105. Lower scores indicate better health-related quality of life
Time frame: 3 months
Six minute walk test
Six-minute walk distance (6MWD), measured as the total distance in metres walked by the participant during a standardized six-minute walk test. A greater distance indicates better functional exercise capacity.
Time frame: 3 months
Generic Quality of life
European Quality of Life (EQ-5D-5L) Questionnaire evaluates five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has five response levels. The outcome will be expressed as the EQ-5D-5L utility index score, with higher scores indicating better health-related quality of life.
Time frame: 3 months
Self-rated health (EQ-5D-5L)
EQ-VAS score, ranging from 0 to 100, where 0 represents the worst imaginable health state and 100 represents the best imaginable health state. Higher scores indicate better perceived health status.
Time frame: 3 months
Tobacco cessation
Smoking cessation will be assessed based on self-reported tobacco use status. Current smokers at baseline who report no tobacco use at follow-up will be classified as having achieved tobacco cessation.
Time frame: 3 months
Self-reported Frailty
Frailty assessed by Fried Frailty Phenotype tool
Time frame: 3 months
Caregiver's depression - Patient Health Questionnaire-9
PHQ-9 total score, ranging from 0 to 27, with each of the nine items scored from 0 to 3. Higher scores indicate greater severity of depressive symptoms.
Time frame: 3 months
Caregiver's Quality of Life - EQ-5D-5L
Quality of life will be assessed using the EQ-5D-5L questionnaire, which evaluates five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has five response levels. The outcome will be expressed as the EQ-5D-5L utility index score and visual analogue scale (EQ-VAS), with higher scores indicating better health-related quality of life.
Time frame: at 3 months
Costs of care
Cost effectiveness as assessed by a piloted tool
Time frame: Median follow-up of 1 year
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Plan to share: Yes — We are preparing a IPD sharing plan
Supporting information: Study protocol, Statistical analysis plan, Informed consent form
Time frame: 12 months after completion of study follow-up
Access criteria: Bonafide researchers will be provided access to data
No publications or documents are linked to this record.
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Centre for Chronic Disease Control, India