An interventional study of Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin) in Obesity (Disorder), sponsored by Anahuac University. Recruiting at 1 site in Mexico. Open to participants aged 30 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Anahuac University · Not applicable, Interventional, and Treatment
This randomized crossover clinical trial aims to evaluate the effect of a synbiotic containing Lactobacillus acidophilus and inulin on cognitive function in adults with obesity and mild cognitive impairment. Forty participants aged 30-40 years will be randomly assigned to two groups. Participants will receive either the synbiotic intervention or a control preparation, followed by crossover to the alternate intervention. Cognitive function will be evaluated using the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Memory Alteration Test (M@T). Fecal butyrate and Lactobacillus acidophilus, as well as serum inflammatory cytokines and BDNF, will also be assessed to explore potential mechanisms involving the gut-brain axis.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 40 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Anahuac University is the lead sponsor of 10 studies on the registry; 4 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will initially receive the synbiotic intervention and subsequently cross over to the control intervention.
Dietary Supplement: Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin)
Participants will initially receive the synbiotic intervention and subsequently cross over to the control intervention.
Dietary Supplement: Synbiotic (Lactobacillus acidophilus LA-5 and Agave Inulin)
Participants will receive 2 g of Lactobacillus acidophilus (4 × 10⁹ CFU) plus 7 g of agave inulin, combined with 20 g of a powder containing almond, cinnamon, vanilla, and oats, dissolved in water and administered once daily for 12 weeks.
Change in Montreal Cognitive Assessment (MoCA) Score
The total score ranges from 0 to 30 points, with higher scores indicating better cognitive performance
Time frame: Baseline, Week 12, and Week 26.
Change in Mini-Mental State Examination (MMSE) Score
The total score ranges from 0 to 30 points, with higher scores indicating better cognitive performance.
Time frame: Baseline, Week 12, and Week 26.
Change in Memory Alteration Test (M@T) Score
The total score ranges from 0 to 50 points, with higher scores indicating better memory performance.
Time frame: Baseline, Week 12, and Week 26.
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