An observational study in Postmastectomy Lymphedema, sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by Istanbul Physical Medicine Rehabilitation Training and Research Hospital · Observational
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Among 34 studies in Breast Cancer Lymphedema with a site in Turkey — 5 open to participants now, 7 under way, none of them phase 3. Breast Cancer Lymphedema · Turkey.
Among the 34 studies in Breast Cancer Lymphedema with a site in Turkey, this one is the 9th largest by enrollment of the 12 observational ones that give a count, is one of 4 that started in 2025, is one of 12 observational ones, and was the 32nd registered.
124 studies on the registry are indexed under Breast Cancer Lymphedema; 39 are open to participants now.
Browse Breast Cancer Lymphedema studies →5 of the 34 studies in Breast Cancer Lymphedema with a site in Turkey are open now. Recruiting first, the newest first:
Antalya City Hospital · Sites in Turkey
Ages 18–80 · Women only
Pamukkale University · Sites in Turkey
Ages 18–65 · Women only
Ankara City Hospital Bilkent · Sites in Turkey
Ages 18+ · Women only
Abant Izzet Baysal University · Sites in Turkey
Ages 18–85 · Women only
Hacettepe University · Sites in Turkey
Ages 40–65 · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 24 Breast Cancer Lymphedema studies recruiting now, 8 (33%) set no upper age limit and 9 (38%) stop at 75 or younger; none take children under 18; 2 take healthy volunteers.
This study: 18 Years and older · female.
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34 studies; the count open now beside each. This study's row is marked.
First in 2012; this study’s year is marked. 4 started in 2025.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 42 is below the median of 80 across 25 observational studies indexed under Breast Cancer Lymphedema.
Median enrollment 40 across the 22 interventional studies, 56 across the 12 observational. Of the 23 that completed or were terminated, 1 (4%) have results posted.
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None of the 34 has an industry lead sponsor. The 10 most frequent:
Istanbul Physical Medicine Rehabilitation Training and Research Hospital is the lead sponsor of 123 studies on the registry; 26 are open to participants now.
Istanbul Physical Medicine Rehabilitation Training and Research Hospital has 1 study filed under Breast Cancer Lymphedema — fewer than ten, so there is no comparison to draw.
4 of the studies in Breast Cancer Lymphedema with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07154043Pamukkale UniversityComparison of IPC Therapy as an Alternative or an Adjunct to MLD Within CDT for BCRL | 2026-12-01 |
| NCT06697158Abant Izzet Baysal UniversityInvestigation of the Effects of Complex Decongestive Physiotherapy on Sleep Quality and Quality of Life in Women With Breast Cancer Related Lymphedema | 2026-12-12 |
| NCT07673939Hacettepe UniversityEffects of Core-Focused Exercise Training and Kinesiology Taping in Women With Breast Cancer-Related Lymphedema | 2027-08-15 |
| NCT07780240Antalya City HospitalAxillary Web Syndrome After Breast Cancer Surgery: Incidence, Risk Factors, and Functional Outcomes | 2027-10 |
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Among the 34 studies in Breast Cancer Lymphedema with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
Research and Literature Summary / References
(The research summary must not exceed 250 words and must be written in a clear, easily understandable form.)
Lymphedema is a chronic and progressive disease that develops as a result of the accumulation of protein-rich fluid in the interstitial tissue following disruption of lymphatic drainage. Lymphedema of the upper extremity seen after breast cancer treatment is the most frequently encountered form, and it causes loss of function, restriction of movement, and deterioration in quality of life. Manual lymphatic drainage (MLD), a component of complex decongestive therapy (CDT), is a method of proven efficacy in reducing skin and subcutaneous tissue thickness. Demonstrated that compression applied at different pressures produced a significant reduction in skin and subcutaneous tissue thickness and accelerated the resolution of edema.
High-resolution ultrasound is used as a reliable method for evaluating the skin, subcutaneous adipose tissue, and fascial structures in lymphedema.Reported that in patients with lymphedema there is thickening of the cutis and subcutaneous tissue, an increase in echogenicity, and structural changes in the fascial structures, and that these changes may show a regional distribution.
In another study by the same research group, it was determined that in patients with lymphedema the superficial and deep fasciae are thinner compared with healthy individuals. It was emphasized that this may be an important clue regarding the role of fascial structure in the development of lymphedema.
In this thesis study, the effect of MLD treatment on days 1 and 15 in patients with stage 1-2 lymphedema will be evaluated by ultrasound, and the relationship between changes in subcutaneous tissue thickness and deep fascia thickness will be investigated. The aim is thereby to objectively demonstrate the response given to treatment and to make clinical rehabilitation more individualized.
This study will include 42 patients presenting to the Istanbul Physical Therapy and Rehabilitation Training and Research Hospital who have been diagnosed with post-mastectomy lymphedema.
Inclusion Criteria:
Inclusion Criteria:
Exclusion Criteria:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Manual lymphatic drainage (MLD) was applied by a physiotherapist experienced in lymphedema management. Sessions lasted \[45\] minutes and were performed 5 days per week for 3 weeks, for a total of 15 sessions. Treatment started with proximal clearing of the neck, contralateral axillary and inguinal nodes, followed by distal- to-proximal drainage of the affected upper limb. MLD was combined with multilayer short-stretch compression bandaging, skin care and remedial exercises as part of complete decongestive therapy.Limb circumference and ultrasonographic measurements of subcutaneous tissue and deep fascia thickness were obtained on day 1 and day 15.
measurement of subcutan tissue and deep fascia thickness
Time frame: 3 months
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Nov 2025 to primary completion in Jun 2026, 6 months.
Of 12 observational studies under Breast Cancer Lymphedema, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 27. This study's 6 months is below that.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Oct 2025. You cannot join it, but the record below documents what was studied.
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Istanbul Physical Medicine Rehabilitation Training and Research Hospital →