An interventional study of Group A and Group B in Hyperhidrosis, sponsored by Fayoum University Hospital. Not yet recruiting. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by Fayoum University Hospital · Not applicable, Interventional, and Treatment
Palmar hyperhidrosis is a medical condition characterized by excessive sweating specifically from the palms of the hands. This condition can significantly impact an individual's quality of life, leading to social embarrassment, anxiety, and difficulties in daily activities. It is classified as a type of primary hyperhidrosis, which means it occurs without an identifiable underlying medical cause.
The prevalence of palmar hyperhidrosis is estimated to affect about 1% to 3% of the population. Symptoms typically begin in childhood or adolescence, often becoming more pronounced during periods of hormonal changes such as puberty. The condition may run in families, suggesting a genetic predisposition.
The underlying mechanism involves hyperactivity of the sympathetic nervous system, particularly affecting the eccrine sweat glands located in the palms .
Unlike normal sweating, which primarily serves thermoregulation (cooling the body), palmar hyperhidrosis is triggered by emotional stimuli such as stress or anxiety rather than heat. This inappropriate activation leads to excessive sweating that can occur even at rest .
Diagnosis is primarily clinical and based on patient history and visible signs of excessive sweating. Patients often report episodes that are bilateral and symmetrical, with cold and wet palms that may appear pale or blushed. The diagnosis does not typically require extensive testing unless secondary causes are suspected.
Treatment for palmar hyperhidrosis can be challenging due to varying degrees of severity and individual responses to therapies.
Common treatment options include topical treatments as aluminum chloride hexahydrate which is considered one of the most effective topical treatments for palmar hyperhidrosis. It works by blocking sweat pores and reducing gland activity. Application involves using a concentrated solution on dry skin at night until symptoms improve, followed by maintenance therapy.
Another option of treatment is iontophoresis; this technique uses electrical currents to temporarily block sweat gland function. It requires multiple sessions but can be effective for many patients.
Botulinum toxin type A can be injected into affected areas to inhibit neurotransmitter release responsible for activating sweat glands. While effective, this treatment requires repeated injections every few months due to its temporary effects .
Anticholinergic drugs have been used but are often limited by side effects such as dry mouth and constipation at effective dosages .
Regarding surgical options; surgical sympathectomy is considered a last resort for severe cases where other treatments have failed. This procedure involves cutting nerves that trigger sweating but carries risks such as compensatory sweating in other body areas.
Finally, palmar hyperhidrosis is a common yet often underreported condition that can severely affect individuals' lives due to its social implications and discomfort associated with excessive sweating. Treatment options vary widely in effectiveness and side effects, necessitating a tailored approach based on individual needs.
Study tools:
A total of 50 patients will be categorized into 2 groups:
Objective Sweating Assessment:
Stellate Ganglion Block 20% alcohol with steroid local anesthetic technique
Follow up Signs of success of the block as drop of eye lid, redness eye and flushing of half side of the face Follow up hotness and dryness of hand after 1 hour of injection . Follow up after 1 week, injection may be repeated If dryness disappear.
Stellate Ganglion Block steroid local anesthetic technique only
Follow-Up
Follow-up will include periodical outpatient visits during which all evaluations will be repeated. Owing to rapid response, forefinger temperature will also be determined 1 hour after treatment.
Follow up for 6 months
Assessment:
A score of 1 or 2 will be classified as mild or moderate hyperhidrosis. A score of 3 or 4 will be classified as severe hyper-hidrosis. A 1-point decrease in the patient's sweating scale means a 50% decrease in sweat production, and a 2-point decrease means an 80% decrease in sweat production, a 3-point decrease means about an 90% decrease in sweat production (Solish et al., 2007).
Study outcomes:
Secondary outcome parameters:
Preoperative, intraoperative, and postoperative evaluation of measured hemodynamic parameters.
. Number of injection needed to overcome hyperhydrosis.
Ethical Consideration:
Participating patients will sign informed written consent after thorough explanation of the details and purpose of the current study.
Patients have the right to withdraw from the study at any phase without being adversely impacted regarding the medical care they should receive.
The study protocol will be approved by the Ethical Research Committee of Anesthesia Department and Faculty of Medicine, Fayoum University.
Confidentiality of data will be maintained by the following:
Data will screen, for normality assumption test and homogeneity of variance, normality test of data using Kolmogorov Smirnov test will use, that reflect the data is normally distributed or non-normally distributed after removal outliers that detect by box and whiskers plots. All these findings will allow conducting parametric or non-parametric analysis. The statistical analysis will conduct by using statistical SPSS Package program version 25 for Windows (SPSS, Inc., Chicago, IL). The following statistical procedures will perform for:
111 studies on the registry are indexed under Hyperhidrosis; 10 are open to participants now.
This study's planned enrollment of 50 is close to the median of 50 across 99 interventional studies indexed under Hyperhidrosis.
Browse Hyperhidrosis studies →Fayoum University Hospital is the lead sponsor of 77 studies on the registry; 14 are open to participants now.
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Exclusion Criteria:
Procedure: Group A
Procedure: Group B
The aim of the study is to compare between 20% alcohol with steroid local anesthetic technique versus steroid local anesthetic technique only in stellate ganglion injection in treatment of idiopathic palmoplantar hyperhidrosis.
The aim of the study is to compare between 20% alcohol with steroid local anesthetic technique versus steroid local anesthetic technique only in stellate ganglion injection in treatment of idiopathic palmoplantar hyperhidrosis.
hyperhydrosis severity scale
presence/absence of hyperhidrosis
Time frame: After 1 hour of injection
No study locations are listed for this record.
Plan to share: No
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Fayoum University Hospital