An interventional study of Fospropofol disodium and Propofol in Fospropofol Disodium, sponsored by Tongji Hospital. Recruiting at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Tongji Hospital · Not applicable, Interventional, and Other
Endoscopic sinus surgery (ESS) is a primary surgical approach for treating chronic rhinosinusitis, nasal polyps, and other conditions that are unresponsive to conservative therapy. A clear surgical field is a critical prerequisite for ensuring precision, efficiency, and the avoidance of injury to vital structures such as the orbit and the skull base. Currently, the anesthetic regimens commonly used for ESS include total intravenous anesthesia (TIVA), inhalational anesthesia (IA), and intravenous-inhalational combined anesthesia (IVIH). However, there remains controversy regarding the comparative effects of these three modalities on surgical field quality. IVIH, as an anesthetic strategy that integrates the advantages of both intravenous and inhalational agents, is widely employed in clinical practice. In the context of ESS, it may reduce the dose of individual agents through combination therapy, thereby minimizing dose-related adverse effects. Some studies have shown that propofol-based TIVA provides better surgical field conditions than inhalational anesthetics (e.g., desflurane, sevoflurane), but does not significantly reduce total blood loss or shorten operative time. Nevertheless, propofol is associated with drawbacks such as injection pain and propofol infusion syndrome. Fospropofol disodium, a water-soluble prodrug of propofol, offers a significant advantage in reducing injection pain and provides more stable hemodynamic profiles.
Tongji Hospital is the lead sponsor of 386 studies on the registry; 209 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Propofol induction (1-2 mg/kg) and propofol maintenance (5-12 mg/kg/h).
Drug: Propofol
Fospropofol disodium induction (10-20 mg/kg) and fospropofol disodium maintenance (5-12 mg/kg/h).
Drug: Fospropofol disodium
Propofol induction (1-2 mg/kg) and maintenance with propofol plus sevoflurane (1.0%).
Drug: Propofol
Fospropofol disodium induction (10-20 mg/kg) and maintenance with fospropofol disodium plus sevoflurane (1.0%).
Drug: Fospropofol disodium
Fospropofol disodium induction and fospropofol disodium maintenance with or without sevoflurane.
Propofol induction and propofol maintenance with or without sevoflurane.
The score of the Wormald scale
The Wormald scales was used to assess the quality of the surgical field, 0-10 points, with higher scores indicating worse visual field.
Time frame: From the start of surgery to the end of surgery
The score of the Boezaart scale
The Boezaart scales was used to assess the quality of the surgical field, 0-5 points, with higher scores indicating worse visual field.
Time frame: From the start of surgery to the end of surgery
Total blood loss
Total fluid volume in the suction canister at the end of surgery minus the total irrigation volume during surgery
Time frame: Perioperative
The rate of bleeding
Total blood loss divided by surgical duration
Time frame: Perioperative
Induction time
From the start of anesthesia to loss of consciousness
Time frame: Perioperative
Extubation time
From the end of anesthesia to extubation
Time frame: Perioperative
Emergence time
From the end of anesthesia to recovery of consciousness
Time frame: Perioperative
PACU length of stay
From admission to the PACU until meeting discharge criteria
Time frame: Perioperative
Emergence agitation
Emergence agitation was assessed using the Richmond Agitation-Sedation Scale (RASS), the range is between -5 and +4, higher scores mean a worse outcome in terms of sedation level (too agitated) and a worse outcome in terms of over-sedation (too deeply sedated).
Time frame: Perioperative
Postoperative pain score
Postoperative pain score was assessed using the Visual Analogue Scale (VAS), the range is between 0-10, higher scores mean a worse outcome (indicating more severe pain).
Time frame: Perioperative
Postoperative nausea and vomiting (PONV)
Use a questionnaire to assess the incidence of postoperative nausea and vomiting.
Time frame: Perioperative
Plan to share: Yes
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Studies of the drugs tested here: Fospropofol · Propofol