ClinicalTrials.gg
RecruitingNCT07784296AMPR-OS-2503Updated Aug 25, 2026

Effectiveness and Safety of Sequential Triple Combination Therapy (Amlodipine/Losartan/Chlorthalidone) in Korean Patients With Hypertension

An observational study in Hypertension, sponsored by Hanmi Pharmaceutical Company Limited. Recruiting at 1 site in South Korea. Per ClinicalTrials.gov, last updated 2026-08-25.

Sponsored by Hanmi Pharmaceutical Company Limited · Observational

From the registry’s dates

  • Started Mar 2026; still recruiting 7 months later.
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
3,500
Sex
All
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Study summary

A multicenter, prospective, non-interventional, observational study to evaluate effectiveness and safety of sequential triple combination therapy (amlodipine/losartan/chlorthalidone) in Korean patients with hypertension

02

Conditions studied

  • Hypertension

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03

In context

Hypertension

6,114 studies on the registry are indexed under Hypertension; 912 are open to participants now.

This study's planned enrollment of 3,500 is above the median of 350 across 1,163 observational studies indexed under Hypertension.

Browse Hypertension studies →

Lead sponsor

Hanmi Pharmaceutical Company Limited is the lead sponsor of 190 studies on the registry; 11 are open to participants now.

Of its 11 completed or terminated interventional studies of FDA-regulated products, 6 (55%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

General hospital

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Korean patients aged 19 years or older diagnosed with hypertension
  2. Individuals newly diagnosed with hypertension or currently taking a single antihypertensive drug
  3. Individuals for whom administration of Amoprel tablets has been determined based on the researcher's medical judgment
  4. Individuals who have heard an explanation of this study and have voluntarily given written consent to participate in the study

Exclusion criteria

Exclusion Criteria:

  1. Individuals falling under the listed in the precautions for use of Amoprel Tab. or Amozartan Plus Tab.
  2. Pregnant women, women who may be pregnant, and nursing mothers
  3. Individuals currently participating in an interventional study
  4. Individuals deemed unsuitable for participation in this study by the researcher for other reasons
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
3,500 participants (estimated)
Target follow-up
6 Months
Patient registry
Yes

Interventions

  • DrugAMOPREL TAB 1.67/16.67/4.17mg

    Follow-up of subjects prescribed medication in a non-intervention study

06

What researchers measure

Primary outcomes

  1. The change in Systolic Blood Pressure (SBP) relative to baseline

    Time frame: the 6-month time

Secondary outcomes

  1. effectiveness of sequential triple combination therapy (amlodipine/losartan/chlorthalidone)

    Change from baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) at 2 and 4 months, and change from baseline in DBP at 6 months

    Time frame: 2, 4, 6 months

  2. Prescription patterns of a triple-therapy-based stepwise treatment strategy

    Proportion of Participants by Study Drug Dosage at Months 2, 4, and 6

    Time frame: 2, 4, 6 months

  3. safety of sequential triple combination therapy (amlodipine/losartan/chlorthalidone)

    Incidence of Adverse Events During the 6-Month Follow-up Period

    Time frame: 2, 4 , 6 months

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Study locations

1 of 1 sites recruiting
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 25, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07784296
Responsible party
Sponsor
First posted
Aug 25, 2026
Start date
Mar 19, 2026
Primary completion
Aug 31, 2028 (estimated)
Completion
Aug 31, 2028 (estimated)
Last update
Aug 25, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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