An interventional study of Dyadic Multicomponent Intervention (DMI) and Dyadic Benefit-Finding Intervention (DBFI) in Schizophrenia, sponsored by Chinese University of Hong Kong. Not yet recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-25.
Sponsored by Chinese University of Hong Kong · Not applicable, Interventional, and Supportive care
Among 247 studies in Schizophrenia with a site in China — 61 open to participants now, 65 under way, 4 of them phase 3. Schizophrenia · China.
Among the 247 studies in Schizophrenia with a site in China, this one is the 55th largest by planned enrollment of the 212 interventional ones that give a count, is one of 2 that started in 2027, is one of 106 with no phase, reaches primary completion later than 58 of the 64 other live ones, and was the 241st registered.
3,563 studies on the registry are indexed under Schizophrenia; 491 are open to participants now.
Browse Schizophrenia studies →61 of the 247 studies in Schizophrenia with a site in China are open now. Recruiting first, the newest first:
Second Xiangya Hospital of Central South University · Sites in China
Central South University · Sites in China
Second Xiangya Hospital of Central South University · Sites in China
Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University · Sites in China
Central South University · Sites in China
A study can be open while its sites in China have not opened yet or have stopped. Only those recruiting at a site in China →
Of the 331 Schizophrenia studies recruiting now, 63 (19%) set no upper age limit and 257 (78%) stop at 75 or younger; 42 take children under 18; 83 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
247 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 25 · Phase 2 16 · Phase 3 38 · Phase 4 33
First in 2002; this study’s year is marked. 2 started in 2027.
This study's planned enrollment of 228 is above the median of 71 across 2,944 interventional studies indexed under Schizophrenia.
Median enrollment 100 across the 212 interventional studies, 300 across the 35 observational. Of the 118 that completed or were terminated, 21 (18%) have results posted.
This tab as a report to print or save as PDF → With an account.
67 of 247 have an industry lead sponsor. The 10 most frequent:
Chinese University of Hong Kong is the lead sponsor of 1,454 studies on the registry; 474 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Chinese University of Hong Kong has 4 studies filed under Schizophrenia — fewer than ten, so there is no comparison to draw.
19 of the studies in Schizophrenia with a site in China that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06112067Shanghai Mental Health CenterEfficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders | 2026-11 |
| NCT07521683NeuShen TherapeuticsA Phase II Clinical Study to Evaluate the Efficacy and Safety of NS-136 in the Treatment of Schizophrenia | 2026-11 |
| NCT06802939Shanghai Mental Health CenterRTMS for Refractory Auditory Hallucinations Based on Personalized Targets Using Magnetoencephalography | 2026-12-10 |
| NCT07493551CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.A Bioequivalence Study of PP3M in Patients With Schizophrenia | 2026-12-31 |
| NCT07356765Tianjin Anding HospitalBerberine in Treating Negative Symptoms of Schizophrenia: Clinical Efficacy and Mechanisms | 2027-01 |
Among the 247 studies in Schizophrenia with a site in China, from their registry updates:
This tab as a report to print or save as PDF → With an account.
The goal of this clinical trial is to learn if a new support program can improve the quality of informal care for people with schizophrenia in rural China. Informal care means the unpaid care given by family members. Quality of care involves both the care that family members give and the care that people with schizophrenia receive. The study also looks at whether the program improves the health and well-being of both groups.
The main questions it aims to answer are:
Researchers will compare three groups to see which works best:
Each person with schizophrenia takes part together with their family caregiver as a pair. Participants will:
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
This arm includes 38 dyads (38 persons with schizophrenia and 38 informal caregivers, 76 participants). Participants receive the full Dyadic Multicomponent Intervention (DMI), which combines psychoeducation, physical exercise, and spiritual training, over 8 weeks.
Behavioral: Dyadic Multicomponent Intervention (DMI)
This arm includes 38 dyads (38 persons with schizophrenia and 38 informal caregivers, 76 participants). Participants receive only the Dyadic Benefit-Finding Intervention (DBFI) over 8 weeks, without the exercise or spiritual training components.
Behavioral: Dyadic Benefit-Finding Intervention (DBFI)
This arm includes 38 dyads (38 persons with schizophrenia and 38 informal caregivers, 76 participants). Participants receive only routine care over the 8-week period, with no additional study intervention.
An 8-week program delivered face-to-face to each person-with-schizophrenia and informal-caregiver dyad together, one 120-minute session per week. Each session combines three components: Dyadic Benefit-Finding Intervention (psychoeducation and positive reappraisal, 60 minutes), Dyadic Exercise Intervention (guided mind-body exercise such as Qigong, Tai Chi, or Baduanjin, 30 minutes), and Dyadic Spiritual Training (mindfulness and life review, 30 minutes). Content is tailored to each dyad and delivered by a trained team of psychiatrists, exercise physiologists, and social workers.
An 8-week program delivered face-to-face to each person-with-schizophrenia and informal-caregiver dyad together, one 60-minute session per week. It provides psychoeducation about schizophrenia and caregiving, benefit-finding diaries, and guided practice in positive reappraisal, helping dyads recognize positive experiences and coping resources. This arm does not include the exercise or spiritual training components. It is delivered by a trained team of psychiatrists and social workers.
Positive Aspects of Caregiving
Positive aspects of caregiving reported by informal caregivers, measured with the 11-item Positive Aspects of Caregiving Scale (C-PAC) on a 5-point Likert scale. Higher scores indicate more positive appraisal of caregiving.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Exemplary Care
Quality of caregiving reported by informal caregivers, measured with the 11-item Exemplary Care Scale on a 4-point scale. Higher scores indicate higher-quality caregiving.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Commitment to Care
Commitment to caregiving reported by informal caregivers, measured with the 12-item Valued Living Questionnaire Adapted to Caregiving (VLQAC) on a 10-point Likert scale. Higher scores indicate stronger commitment to valued caregiving.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Adequacy of Care (Activities of Daily Living)
Adequacy of care received, reported by persons with schizophrenia, measured with an 18-item activities of daily living (ADL) scale on a 4-point scale. Higher scores indicate greater adequacy of care received.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Satisfaction with Care
Satisfaction with care received, reported by persons with schizophrenia, measured with the Client Assessment of Treatment Scale (CAT) on a 10-point scale. Higher scores indicate greater satisfaction with care.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Caregiver Burnout / Strain
Caregiver strain reported by informal caregivers, measured with the 13-item Modified Caregiver Strain Index (M-CSI) on a 3-point scale. Higher scores indicate greater caregiver strain.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Caregiver Psychological Health
Psychological health reported by informal caregivers, measured with the 21-item Depression, Anxiety and Stress Scale (DASS-21) on a 4-point scale. Higher scores indicate greater depression, anxiety, and stress.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Treatment Adherence (Care Recipient)
Treatment adherence of persons with schizophrenia, rated by health professionals using the observer-rated Kemp Compliance Scale (KCS) on a 7-point Likert scale. Higher scores indicate better treatment adherence.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Social Functioning (Care Recipient)
Social functioning of persons with schizophrenia, assessed by health professionals using the 10-item Social Disability Screening Schedule (SDSS). Higher scores indicate greater social disability.
Time frame: Baseline (T0), immediately after the intervention (T1), and 6 months post-intervention (T2)
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Jul 2027; primary completion for Nov 2028, 16 months later.
Of 753 non-industry interventional studies with no phase under Schizophrenia, half reached primary completion within 33 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 56. This study's planned 16 months is below that.
Counting every sponsor, half of 766 studies reached it within 32 months; a quarter within 16 and three quarters within 56.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Chinese University of Hong Kong →