An interventional study of Femoral venting+ intramedullary nailing and Standard intramedullary nailing in Femur Fracture, sponsored by The University of Texas Health Science Center, Houston. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2026-08-21.
Sponsored by The University of Texas Health Science Center, Houston · Not applicable, Interventional, and Treatment
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Among 46 studies in Femoral Fractures with a site in United States — 6 open to participants now, 7 under way, none of them phase 3. Femoral Fractures · United States.
Among the 46 studies in Femoral Fractures with a site in United States, this one is the 20th largest by planned enrollment of the 29 interventional ones that give a count, is one of 2 that started in 2026, is one of 21 with no phase, and was the 46th registered.
186 studies on the registry are indexed under Femoral Fractures; 38 are open to participants now.
Browse Femoral Fractures studies →6 of the 46 studies in Femoral Fractures with a site in United States are open now. Recruiting first, the newest first:
University of Southern California · Sites in United States, Canada, Norway and 2 more countries
Ages 60+
Michael C Willey · Sites in United States
Ages 65+
University of California, San Diego · Sites in United States
Ages 18+
University of California, San Diego · Sites in United States
Ages 18+ · Healthy volunteers
LifeNet Health · Sites in United States
A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →
Of the 25 Femoral Fractures studies recruiting now, 14 (56%) set no upper age limit and 2 (8%) stop at 75 or younger; 2 take children under 18; 3 take healthy volunteers.
This study: 18 Years to 100 Years · all sexes · no healthy volunteers.
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46 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 2 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 10 is below the median of 61 across 114 interventional studies indexed under Femoral Fractures.
Median enrollment 55 across the 29 interventional studies, 80 across the 17 observational. Of the 34 that completed or were terminated, 10 (29%) have results posted.
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9 of 46 have an industry lead sponsor. The 10 most frequent:
The University of Texas Health Science Center, Houston is the lead sponsor of 899 studies on the registry; 214 are open to participants now.
Of its 174 completed or terminated interventional studies of FDA-regulated products, 142 (82%) have results posted.
The University of Texas Health Science Center, Houston has 1 study filed under Femoral Fractures — fewer than ten, so there is no comparison to draw.
3 of the studies in Femoral Fractures with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT06032299Mayo ClinicDual Implant Versus Single Implant Distal End of Femur | 2026-11 |
| NCT06050668Michael C WilleyEssential Amino Acid Supplementation for Femoral Fragility Fractures | 2026-12 |
| NCT07778238The University of Texas Health Science Center, HoustonEffect of a Femoral Venting Hole on Embolic Load in Prophylactic Intramedullary Nailing | 2027-08-01 |
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Among the 46 studies in Femoral Fractures with a site in United States, from their registry updates:
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The purpose of this study is to measure intraoperative embolic burden during prophylactic intramedullary nailing of impending femur fractures in patients treated with versus without venting, to find the association between embolic burden and intraoperative physiologic changes, measured using standard anesthesia monitors and charted data, to measure Immediate and short-term cardiopulmonary outcomes assessed during hospitalization and to assess procedure-related complications associated with venting
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Impending fracture secondary to a pathologic process, including:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Procedure: Femoral venting+ intramedullary nailing · Procedure: Standard intramedullary nailing
Procedure: Standard intramedullary nailing
Participants will undergo femoral venting prior to prophylactic intramedullary fixation .
Participants will undergo prophylactic intramedullary fixation
Change in Embolic burden as assessed by intraoperative transthoracic echocardiography (TTE)
Embolic burden is defined as the presence, frequency, and severity (graded semi-quantitatively) of echogenic embolic events within the right atrium, right ventricle, and pulmonary artery outflow tract.
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 after start of surgery)
Change in Embolic Burden as assessed by change in Heart rate
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 after start of surgery)
Change in Embolic Burden as assessed by change in Mean arterial pressure
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 after start of surgery)
Change in Embolic Burden as assessed by change in oxygen saturation
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 hours after start of surgery)
Change in Embolic Burden as assessed by change in end-tidal carbon dioxide
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 hours after start of surgery)
Embolic Burden as assessed by change in vasopressor requirement
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 hours after start of surgery)
Embolic Burden as assessed by change in arterial blood gas parameters (PaO₂, partial pressure of carbon dioxide in arterial blood(PaCO₂), A-a gradient when obtained as part of clinical care).
Time frame: baseline (prior to canal instrumentation), during canal preparation/reaming, during nail insertion, and immediately post-procedure(about 1 to 2 hours after start of surgery)
Need for postoperative vasopressor or respiratory support
Time frame: Intraoperative through hospital discharge (about 2 to 3 days after surgery)
Number of participants that need ICU admission
Time frame: at hospital discharge (about 2 to 3 days after surgery)
Length of hospital stay
Time frame: at hospital discharge (about 2 to 3 days after surgery)
Number of participants with postoperative hematoma
Time frame: During hospitalization and up to 30 days postoperatively if available through routine clinical follow-up
Number of participants with surgical site infection
Time frame: During hospitalization and up to 30 days postoperatively if available through routine clinical follow-up
Number of participants with wound complications
Time frame: During hospitalization and up to 30 days postoperatively if available through routine clinical follow-up
Number of participants with peri-implant fracture or iatrogenic fracture
Time frame: During hospitalization and up to 30 days postoperatively if available through routine clinical follow-up
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Sep 2026; primary completion for Aug 2027, 11 months later.
Of 50 non-industry interventional studies with no phase under Femoral Fractures, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 50. This study's planned 11 months is below that.
Counting every sponsor, half of 53 studies reached it within 23 months; a quarter within 9 and three quarters within 50.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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The University of Texas Health Science Center, Houston →