An interventional study of Deep Microspicule Cream in Efficacy Validation of Deep Microspicule Cream for Anti-aging and Whitening on Mature Skin, sponsored by Chung Shan Medical University. Not yet recruiting at 1 site in Taiwan. Open to participants aged 40 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Chung Shan Medical University · Not applicable, Interventional, and Other
This study is a single-center, prospective, split-face self-controlled pilot trial designed to evaluate the anti-aging and whitening efficacy of the "Deep Microspicule Cream" (containing patented crystal microspicules encapsulating Penghu seaweed extract) on mature skin.
This study is a single-center, prospective, split-face self-controlled pilot trial.
10 healthy participants aged 40-65 who present signs of skin aging or hyperpigmentation will be enrolled.
Intervention Side (Active): Participants will apply a green-bean-sized amount of Deep Microspicule Cream on the assigned side, gently massaging to let the microspicules roll on the skin, followed by the application of Deep Essence to dissolve the microspicules.
Control Side: Participants will apply Deep Essence only. The applications are performed 3 times per week at bedtime. Clinical evaluations and instrument measurements are scheduled at Day 0 (baseline), Day 14, and Day 28. On assessment days, participants must cleanse their faces and rest in a controlled environment for 25-30 minutes without applying any cosmetics before undergoing non-invasive skin assessments.
Chung Shan Medical University is the lead sponsor of 125 studies on the registry; 25 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
"All 10 participants in this group will undergo two different skincare regimens on randomly assigned sides of the face (left or right) for a duration of 28 days. On the designated intervention side, participants will apply a green-bean-sized amount of Deep Microspicule Cream and gently massage, followed by the application of Deep Essence to dissolve the microspicules. On the opposite control side, participants will apply Deep Essence only as a within-subject control. Both regimens are to be applied three times per week (Mondays, Wednesdays, and Saturdays) at night after cleansing.
Other: Deep Microspicule Cream
"A topical cream (Deep Microspicule Cream) utilizing patented crystal microspicule technology to encapsulate Penghu seaweed extracts (including Caulerpa microphysa, Sargassum hemiphyllum, and Botryocladia leptopoda). These ingredients possess potential anti-inflammatory, antioxidant, and collagen-promoting properties. Participants will apply a green-bean-sized amount of the cream strictly to the randomly assigned intervention side of the face (left or right). The cream should be massaged gently on the designated side to allow the microspicules to roll on the skin surface (avoiding harsh rubbing). This application regimen is to be performed three times per week (Mondays, Wednesdays, and Saturdays) at night after facial cleansing, for a total duration of 28 days."
Skin Hydration,Transepidermal Water Loss (TEWL),Skin Elasticity,Erythema Index,Skin Color
"Using the Cutometer® MPA 580 to sequentially measure skin hydration, transepidermal water loss (TEWL), skin elasticity, erythema index, and skin color."
Time frame: Baseline (Day 0), Day 14, Day 28
skin texture smoothness, visual radiance (glossiness), and skin firmness
"Subjective evaluation of skin improvement including skin feel (texture smoothness), visual radiance (glossiness), and skin firmness, assessed via a 7-point Likert scale (ranging from 1 = very dissatisfied to 7 = very satisfied) .
Time frame: Baseline (Day 0), Day 14, Day 28
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Chung Shan Medical University →