An observational study in Respiratory Inflammation, sponsored by Aalborg University Hospital. Recruiting at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Aalborg University Hospital · Observational
When patients undergo major surgery, they are connected to a ventilator during anesthesia. A heat and moisture exchange filter (HME filter) is routinely placed in the ventilator tubing to ensure that the inhaled air is warm and humidified. Today, HME filters are used routinely in all ventilator treatments. They are typically replaced once a day and discarded as regular waste after use.
The purpose of this study is to investigate whether HME filters contain proteins and small biological particles from the patient's exhaled air.
Aalborg University Hospital is the lead sponsor of 198 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The investigators will include adult patients who are scheduled for elective surgery for non-malignant conditions under general anesthesia with invasive mechanical ventilation. The written and oral study information will be provided at the standard preoperative consultation with the anesthesiologist the day before elective surgery.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Total endogenous protein amount captured in HME filters measured by standard biochemical assays.
Quantification of the total amount of endogenous proteins recovered from heat moisture exchange (HME) filters using Biuret based analysis.
Time frame: Through study completion, an average of 3 months.
Protein molecular weight and isoelectric point distribution in proteins captured by HME filters.
Distribution and representation of captured proteins according to molecular weight and isoelectric point characteristics determined by proteomic analysis.
Time frame: Through study completion, an average of 3 months.
Between-subject variation in exhaled breath protein concentration measured by proteomic analysis.
Variation in protein concentration across HME filter samples collected from different participants, measured using protein quantification methods.
Time frame: Through study completion, an average of 3 months.
Plan to share: No — All data analyses will be performed in our institution as only conventional biochemical analyses will be applied. No external collaborators are needed and hence the investigators have no need to share IPD outside the instutution.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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