An interventional study of Underrunning Water Bathing and Underrunning Water Bath + Massage Combination in Neonatal Hyperbilirubinemia, sponsored by Bozok University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 38 Weeks to 42 Weeks. Per ClinicalTrials.gov, last updated 2026-08-19.
Sponsored by Bozok University · Not applicable, Interventional, and Supportive care
Among 17 studies in Hyperbilirubinemia, Neonatal with a site in Turkey — 4 open to participants now, 4 under way, none of them phase 3. Hyperbilirubinemia, Neonatal · Turkey.
Among the 17 studies in Hyperbilirubinemia, Neonatal with a site in Turkey, this one is the 4th largest by enrollment of the 13 interventional ones that give a count, is one of 5 that started in 2024, is one of 13 with no phase, and was the 13th registered.
96 studies on the registry are indexed under Hyperbilirubinemia, Neonatal; 20 are open to participants now.
Browse Hyperbilirubinemia, Neonatal studies →4 of the 17 studies in Hyperbilirubinemia, Neonatal with a site in Turkey are open now. Recruiting first, the newest first:
Marmara University · Sites in Turkey
Ages 2 days–7 days · Healthy volunteers
Aydin Adnan Menderes University · Sites in Turkey
Ages 2 days–10 days
Karamanoğlu Mehmetbey University · Sites in Turkey
Ages 0 days–28 days
Haseki Training and Research Hospital · Sites in Turkey
Ages 2 hrs–28 days
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 14 Hyperbilirubinemia, Neonatal studies recruiting now, none (0%) set no upper age limit and 14 (100%) stop at 75 or younger; 13 take children under 18; 7 take healthy volunteers.
This study: 38 Weeks to 42 Weeks · all sexes · no healthy volunteers.
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17 studies; the count open now beside each. This study's row is marked.
First in 2020; this study’s year is marked. 5 started in 2024.
This study's enrollment of 90 is close to the median of 100 across 61 interventional studies indexed under Hyperbilirubinemia, Neonatal.
Median enrollment 68 across the 13 interventional studies, 80 across the 4 observational. Of the 12 that completed or were terminated, 0 (0%) have results posted.
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None of the 17 has an industry lead sponsor. The 10 most frequent:
Bozok University is the lead sponsor of 54 studies on the registry; 9 are open to participants now.
Bozok University has 1 study filed under Hyperbilirubinemia, Neonatal — fewer than ten, so there is no comparison to draw.
2 of the studies in Hyperbilirubinemia, Neonatal with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07761689Marmara UniversityThe Effect of Kangaroo Care on Pain in Infants Receiving Phototherapy | 2026-12-30 |
| NCT07610811Aydin Adnan Menderes UniversityFoot Reflexology and Massage in Neonates Receiving Phototherapy | 2027-03-08 |
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Among the 17 studies in Hyperbilirubinemia, Neonatal with a site in Turkey, from their registry updates:
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This randomized controlled study aimed to compare the effects of under running water bathing and underrunning water bathing combined with massage on bilirubin levels in term newborns receiving phototherapy. The study was conducted between June 2024 and March 2025 in the neonatal clinic of Kayseri City Hospital after obtaining institutional permission, ethics approval, and informed consent from the families. Ninety term newborns were randomly assigned to three groups:under running water bathing, under running water bathing +massage, and control (routine care). Bilirubin levels were measured before phototherapy and at the 12th and 24th hours. While bilirubin levels decreased over time in all groups, the underrunning water bathing combined massage group had significantly lower bilirubin levels than the control group at the 24th hour. The use of a underrunning water bath and massage combination is recommended as part of nursing care for term newborns receiving phototherapy.
Physiological hyperbilirubinemia is a common clinical condition in the neonatal period that requires clinical evaluation and medical monitoring. This prospective, randomized controlled experimental study aimed to compare the effects of underrunning water bathing and underrunning water bathing combined with massage on bilirubin levels in term newborns receiving phototherapy.
After obtaining institutional permission, ethics committee approval, and informed consent from the families, the study was conducted between June 2024 and March 2025 in the neonatal clinic of Kayseri City Hospital. The sample consisted of 90 term newborns who met the inclusion criteria. The newborns were randomly assigned to three groups: the Underrunning Water Bath Group (n=30), the Underrunning Water Bath+Massage Group (n=30), and the Control Group (n=30). No intervention other than routine clinical care was applied to the control group. The interventions in the experimental groups were performed by the researcher.
Data were collected using the Introductory Information Form and the Intervention Follow-up Form. Bilirubin levels were measured as total serum bilirubin before phototherapy and at the 12th and 24th hours. Data were analyzed using ANOVA, Bonferroni, Kruskal-Wallis, chi-square, and two-way repeated measures ANOVA tests.
A time-dependent decrease in bilirubin levels was observed in all groups. While no significant difference was found between the groups at the 12th hour (p>0.05), the bilirubin level in the underrunning water bathing combined with massage group was significantly lower than that of the control group at the 24th hour (p\<0.05). The findings suggest that the combination of Underrunning water bathing and massage may be considered as a supportive nursing intervention for term newborns receiving phototherapy.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Term newborns receiving phototherapy will receive a underrunning water bathing before phototherapy as a nursing intervention.
Other: Underrunning Water Bathing
Term newborns receiving phototherapy will receive a underrunning water bathing followed by massage before phototherapy.
Other: Underrunning Water Bath + Massage Combination
Term newborns receiving phototherapy will receive routine clinical care without additional intervention.
Following the baseline (T0) assessment, term newborns received an approximately 5-minute bath under running water as a supportive nursing intervention before the initiation of phototherapy. After the intervention, a second assessment of vital signs (T20) was performed, and phototherapy was subsequently initiated.Vital signs were reassessed at 12 and 24 hours after phototherapy initiation. Total serum bilirubin levels were measured at baseline (T0) and at 12 and 24 hours after phototherapy initiation.
Term newborns received a 5-minute bath under running water followed by a 15-minute massage as a supportive nursing intervention after the baseline (T0) assessment and before the initiation of phototherapy. Following the intervention, a second vital sign assessment (T20) was performed, phototherapy was subsequently initiated.Vital signs were reassessed at 12 and 24 hours after phototherapy initiation. Total serum bilirubin levels were measured at baseline (T0) and at 12 and 24 hours after phototherapy initiation.
Total Serum Bilirubin Level Unit of Measure: mg/dL
Total serum bilirubin levels of term newborns receiving phototherapy will be measured to evaluate the effects of under-running water bathing and under-running water bathing combined with massage compared with a control group. Unit of Measure: mg/dL
Time frame: Baseline (before initiation of phototherapy), 12 hours after initiation of phototherapy, and 24 hours after initiation of phototherapy
Heart Rate-Unit of Measure: Beats/min.
Heart rate was monitored and recorded at predetermined measurement time points in term newborns receiving phototherapy to evaluate the effects of under-running water bathing and under-running water bathing combined with massage compared with a control group.
Time frame: T0 (baseline before initiation of phototherapy), T20 (20 minutes after baseline), T12 (12 hours after initiation of phototherapy), and T24 (24 hours after initiation of phototherapy).
Oxygen Saturation- Unıt of Measure %
Oxygen saturation was monitored and recorded at predetermined measurement time points in term newborns receiving phototherapy to evaluate the effects of under-running water bathing and under-running water bathing combined with massage compared with a control group.
Time frame: T0 (baseline before initiation of phototherapy), T20 (20 minutes after baseline), T12 (12 hours after initiation of phototherapy), and T24 (24 hours after initiation of phototherapy).
Body Temperature-Unıt of Measure °C
Body temperature was monitored and recorded at predetermined measurement time points in term newborns receiving phototherapy to evaluate the effects of under-running water bathing and under-running water bathing combined with massage compared with a control group.
Time frame: T0 (baseline before initiation of phototherapy), T20 (20 minutes after baseline), T12 (12 hours after initiation of phototherapy) , and T24 (24 hours after initiation of phototherapy).
Respiratory Rate- Unıt of Measure Breaths/min
Respiratory rate was measured and recorded at predetermined time points in term newborns receiving phototherapy to evaluate the effects of under-running water bathing and under-running water bathing combined with massage compared with a control group.
Time frame: T0, T20, T12, and T24 .
Plan to share: No — Individual participant data will not be shared due to confidentiality concerns and institutional policies regarding data protection.
No publications or documents are linked to this record.
Ran from Jun 2024 to primary completion in Mar 2025, 8 months.
Of 34 non-industry interventional studies with no phase under Hyperbilirubinemia, Neonatal, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 21. This study's 8 months is below that.
Counting every sponsor, half of 34 studies reached it within 10 months; a quarter within 6 and three quarters within 21.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Hyperbilirubinemia, Neonatal →
Bozok University