ClinicalTrials.gg
Enrolling by invitationNCT07763574Updated Oct 29, 2026

Omega-3 Fatty Acids and Muscle Strength

An interventional study of Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults and Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults in Muscle Strength and Cognitive Function Assessment, sponsored by Gdansk University of Physical Education and Sport. Enrolling by invitation at 1 site in Poland. Open to participants aged 20 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-29.

Sponsored by Gdansk University of Physical Education and Sport · Not applicable, Interventional, and Basic science

Updated Oct 29, 2026Eligibility revisedPrimary outcomes revised+1 moreGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
20 Years to 40 Years
Sex
All
01

Study summary

The purpose of the study is to evaluate the effects of 12-week supplementation with algae-derived DHA combined with strength training on muscle strength, neuromuscular parameters, post-exercise inflammation and cognitive functions in healthy adults compared to fish-derived EPA and DHA combined with strength training, strength training plus placebo and groups receiving only supplementation (algae-derived DHA, fish-derived EPA and DHA or placebo).

The research methods and measurement tools include:

  • Body composition assessed prior to the training intervention and after 12 weeks of training: body mass index (BMI) and body composition - fat mass [kg], body fat percentage [%] and skeletal muscle mass [kg] - will be determined using bioimpedance methods (In Body 720, Biospace, Seoul, Korea) following an overnight fast.
  • Assessment of physical activity levels using the long version of the International Physical Activity Questionnaire (IPAQ).
  • Assessment of mood (UMACL Adjective Mood Scale) and depression (DASS-21, Beck Depression Scale).
  • The SarQoL (Sarcopenia and Quality of Life) questionnaire, used to specifically assess quality of life in people with reduced muscle mass and function.
  • Assessment of participants' diet: each participant will be required to record their diet in 3-day food diaries (to be checked on the first day of testing).
  • Blood sampling: blood will be collected from each participant at two time points before and after the intervention (on an empty stomach, and 40 minutes after the training session). The following will be collected: 1 × 6 ml blood count tube and 3 tubes with a clotting activator, with a total volume of 20 ml. Blood will be collected before the start of the training intervention and after 12 weeks of training. The tubes will be centrifuged at 4 °C (4000 × g for 10 minutes). The serum, plasma and erythrocyte fractions will then be frozen at -80 °C until analysis.
  • Peak force, relative peak force, start time to peak force and force at 100 and 200 milliseconds will be measured during isometric mid-thigh pull-ups using ForceDecks FD Lite dual uniaxial force plates with ForceDecks software (VALD Performance, Brisbane, Queensland, Australia). Upper limb grip strength will be measured using a SAEHAN electronic dynamometer.
  • In addition, muscle electrical activity using a Noraxon Telemyo surface electromyograph will be assessed during isometric mid-thigh pull-ups.
  • Cognitive function will be assessed using the following tests: the Stroop Test, the Corsi Block-Tapping Task and the Pattern Separation Task.

All analysis (beside IPAQ) will be performed before and after 12 weeks of intervention.

  • During the study, all participants will take part in a strength training session (around 40 mins duration) led by an experienced trainer to stimulate the muscles to release myokines.
  • Blood tests will include: BDNF, IGF-1, IL-6, hs-CRP, TNF-alpha, and IL-1B as well as concentrations of metabolites of the kynurenine pathway.
02

Conditions studied

  • Muscle Strength
  • Cognitive Function Assessment

Keywords

  • algae-derived DHA
  • omega-3 fatty acids
  • muscle strength
03

In context

Lead sponsor

Gdansk University of Physical Education and Sport is the lead sponsor of 37 studies on the registry; 11 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

The criteria were revised on the registry on Oct 29, 2026. See what changed

Ages eligible
20 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Eligibility criteria

Inclusion Criteria for the training group:

  • at least 1 year of strength training experience,
  • without chronic or diseases,
  • between the ages of 20 and 40,
  • not obese,
  • not taking omega-3 fatty acids,
  • not taking BCAAs, creatine, anabolic steroids,
  • for women: not pregnant or breastfeeding, and at least 1 year after childbirth (to allow for hormonal balance to stabilize).

For the control group (non-exercisers):

- Requirements as above, except for exercise: we recruit individuals who exercise less than 1 hour per week

Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
120 participants (estimated)

Study arms

  • Experimental
    algae-derived DHA + strength training

    3g of a algae-derived DHA + strength training 3 times a week through 12 weeks

    Dietary Supplement: Effects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults

  • Experimental
    fish-derived omega-3 + strength training

    3g of a fish-derived omega-3 (EPA+DHA) + strength training 3 times a week through 12 weeks

    Dietary Supplement: Effects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults

  • Placebo comparator
    placebo + strength training

    3g of a placebo + strength training 3 times a week through 12 weeks

    Dietary Supplement: Effects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adults

  • Active comparator
    algae-derived DHA without strength training

    3g of a algae-derived DHA through 12 weeks

    Dietary Supplement: Effects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults

  • Active comparator
    fish-derived omega-3 without strength training

    3g of a fish-derived omega-3 (EPA+DHA) through 12 weeks

    Dietary Supplement: Effects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults

  • Placebo comparator
    placebo without strength training

    3g of a placebo through 12 weeks

    Dietary Supplement: Effects of Placebo on Muscle Strength and Cognitive Functions in adults

Interventions

  • Dietary supplementEffects of Strength Training Combined With Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults

    Healthy men and women with few years of training experience will participate in a 12-week strength training program combined with 3g/per day DHA from algae supplementation. The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.

  • Dietary supplementEffects of Strength Training Combined With Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults

    Healthy men and women with few years of training experience will participate in a 12-week strength training program combined with EPA and DHA from fish supplementation (3g per day). The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.

  • Dietary supplementEffects of Strength Training Combined With Placebo on Muscle Strength and Cognitive Functions in adults

    Healthy men and women with few years of training experience will participate in a 12-week strength training program combined with placebo supplementation. The training will be 3 times a week, with 1-hour strength-training exercises for the upper and lower body. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.

  • Dietary supplementEffects of Omega-3s derived from algae on Muscle Strength and Cognitive Functions in adults

    Healthy, untrained men and women will participate in a 12-week DHA from algae supplementation (3g per day). At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.

  • Dietary supplementEffects of Omega-3s derived from fish on Muscle Strength and Cognitive Functions in adults

    Healthy, untrained men and women will participate in a 12-week EPA and DHA from fish supplementation (3g per day). At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.

  • Dietary supplementEffects of Placebo on Muscle Strength and Cognitive Functions in adults

    Healthy, untrained men and women will participate in a 12-week placebo supplementation. At the beginning and end of the intervention, muscle strength will be assessed along with EMG, cognitive function will be evaluated, and blood samples will be collected to measure specific proteins.

06

What researchers measure

Primary outcomes

  1. Relative peak force (N/kg bw) during Isometric Mid-Thigh Pull (IMTP) and Back Squat

    Time frame: 12 weeks intervention

07

Study locations

1 site
08

Updates

1 registry update since Sep 25, 2026
Eligibility
Minimum age 25 Years→20 Years; Maximum age 35 Years→40 Years; 3 criteria edited
What changed in the criteria
  • Editedat least 1-2 years year of strength training experience,
  • Editedbetween the ages of 2520 and 3540,
  • Editednot taking protein, BCAAs, creatine, anabolic steroids, or other supplements
Oct 29, 2026
Primary outcomes
1 edited
What changed in the outcomes
  • EditedPeak force (N), relativeRelative peak force (N/kg bw) and force at 150, 200, and 250 milliseconds (N) during Isometric Mid-Thigh Pull (IMTP) and Back SquatTime frame: 12 weeks intervention
Oct 29, 2026
Title
Effects of Strength Training Combined With Sustainable Source of Omega-3 Fatty Acids on Muscle Strength and Cognitive Functions in Adults Controlled Trial→Omega-3 Fatty Acids and Muscle Strength
Oct 29, 2026
Show all 1 update
  1. Oct 29, 2026
    Eligibility Minimum age 25 Years→20 Years; Maximum age 35 Years→40 Years; 3 criteria edited
    What changed in the criteria
    • Editedat least 1-2 years year of strength training experience,
    • Editedbetween the ages of 2520 and 3540,
    • Editednot taking protein, BCAAs, creatine, anabolic steroids, or other supplements
    Primary outcomes 1 edited
    What changed in the outcomes
    • EditedPeak force (N), relativeRelative peak force (N/kg bw) and force at 150, 200, and 250 milliseconds (N) during Isometric Mid-Thigh Pull (IMTP) and Back SquatTime frame: 12 weeks intervention
    Title Effects of Strength Training Combined With Sustainable Source of Omega-3 Fatty Acids on Muscle Strength and Cognitive Functions in Adults Controlled Trial→Omega-3 Fatty Acids and Muscle Strength
    + 3 other changes: verification date, date precision and description

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT07763574
Lead sponsor
Gdansk University of Physical Education and Sport
Responsible party
Sponsor
First posted
Aug 13, 2026
Start date
Aug 23, 2026
Primary completion
Jan 2029 (estimated)
Completion
Jan 2030 (estimated)
Last update
Oct 29, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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