An observational study in Strabismus, sponsored by Kyoto University, Graduate School of Medicine. Not yet recruiting at 1 site in Japan. Per ClinicalTrials.gov, last updated 2026-08-13.
Sponsored by Kyoto University, Graduate School of Medicine · Observational
This retrospective study constructs the largest multicenter registry of strabismus care in Japan. The registry evaluates real-world surgical and conservative treatment outcomes, safety, and natural history for various types of strabismus, including common, rare, and complex cases.
This retrospective multicenter cohort study collects clinical data from participating academic and high-volume centers in Japan. To minimize chronological bias and maintain feasibility, the observation period depends on the target disease. For common types of strabismus, data extraction is limited to a recent timeframe (e.g., the past 3 years) to avoid the influence of behavioral changes during the coronavirus disease 2019 (COVID-19) pandemic. For rare and complex strabismus, the extraction period extends up to 10 years (from January 2016 to the date of Institutional Review Board approval) to secure an adequate sample size. Statistical analyses will incorporate mixed-effects models to adjust for institutional clustering and differences in patient backgrounds. Missing data will be addressed via multiple imputation before developing prediction models with machine learning algorithms such as random forests.
142 studies on the registry are indexed under Strabismus; 31 are open to participants now.
This study's planned enrollment of 10,000 is above the median of 96 across 54 observational studies indexed under Strabismus.
Browse Strabismus studies →Kyoto University, Graduate School of Medicine is the lead sponsor of 22 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients diagnosed with strabismus who visited participating academic and high-volume eye centers in Japan for clinical evaluation, conservative treatment, or surgery.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients diagnosed with strabismus who underwent clinical evaluation or management (including observation for natural history, conservative treatment, or surgery) at participating institutions.
Procedure: Strabismus Surgery · Other: Conservative Treatment or Observation
Surgical correction of ocular deviation.
Non-surgical management, including clinical observation for natural history, prism therapy, or orthoptic treatment.
Success rate of ocular deviation correction and residual deviation angle
Assess the angle of ocular deviation and determine the success rate of clinical management (including observation for natural history, surgical, or conservative treatments) based on established clinical criteria.
Time frame: At standard observation intervals (2 to 4 weeks, 3 to 6 months, 1 year, and 2 years post-treatment or baseline) and through study completion, up to 10 years.
Recovery of binocular visual function
Evaluate binocularity using standardized clinical tests.
Time frame: Through study completion, up to 10 years
Predictive accuracy of the machine learning nomogram
Compare the predictive performance of the developed machine learning models against actual surgical outcomes.
Time frame: Through study completion, up to 10 years
Plan to share: No
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This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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Kyoto University, Graduate School of Medicine