A Phase 1/2 interventional study of Ayahuasca in Non Epileptic Seizures, sponsored by University of Sao Paulo. Recruiting at 1 site in Brazil. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-08-05.
Sponsored by University of Sao Paulo · Phase 1/2, Interventional, and Treatment
Open label intervention with a single dose of ayahuasca in patients with psychogenic non-epileptic seizures (PNES)
766 studies on the registry are indexed under Seizures; 136 are open to participants now.
This study's planned enrollment of 15 is below the median of 64 across 519 interventional studies indexed under Seizures.
Browse Seizures studies →University of Sao Paulo is the lead sponsor of 1,035 studies on the registry; 95 are open to participants now.
Of its 8 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
single oral dose of ayahuasca (1 ml/kg)
Drug: Ayahuasca
Oral dose of ayahuasca (1 ml/kg)
Seizure frequency
Seizure frequency
Time frame: Baseline, 1, 2, 3 e 4 weeks
Seizure frequency
Seizure frequency
Time frame: Baseline, 1, 2, 3 and 4 weeks
Started Jul 2026 (actual). Primary completion is estimated for Aug 2027, 13 months after the start.
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Studies of the drug tested here: Ayahuasca