An observational study in Lens Diseases, Cataract and Age-related Cataract, sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine. Active, not recruiting at 1 site in China. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-05.
Sponsored by Second Affiliated Hospital, Zhejiang University, School of Medicine · Observational
This multicenter retrospective study will collect clinical data to investigate the associations between preoperative and intraoperative anterior segment structural changes and postoperative surgical outcomes in patients with lens disorders, and to evaluate the clinical benefits of intraoperative optical coherence tomography (iOCT) in lens surgery, with the aim of improving the diagnosis and treatment of lens-related diseases.
Lens disorders, particularly cataract, are a leading cause of blindness worldwide and substantially impair quality of life. Surgery remains the most effective treatment, but pre-existing abnormalities of the lens and adjacent ocular structures, together with unexpected intraoperative events, may increase surgical complexity and affect outcomes. Accurate assessment of anterior segment structures is therefore essential, as abnormalities caused by trauma, congenital disorders, ocular diseases, or systemic conditions may involve the lens, capsule, cornea, iris, or anterior chamber angle. Even during routine phacoemulsification, variations in irrigation pressure, anterior chamber depth, capsular bag integrity, capsular expansion, and residual cortex may influence surgical safety, IOL centration, and postoperative refractive stability. Because some abnormalities cannot be reliably detected preoperatively, intraoperative optical coherence tomography (iOCT) may provide real-time structural information and support surgical decision-making. However, evidence regarding its effects on surgical strategy, visual outcomes, refractive stability, and complications remains limited. This multicenter retrospective study will assess the associations between preoperative and intraoperative anterior segment changes and postoperative outcomes, and evaluate the clinical value of iOCT in lens surgery.
1,629 studies on the registry are indexed under Cataract; 235 are open to participants now.
This study's planned enrollment of 1,200 is above the median of 89 across 475 observational studies indexed under Cataract.
Browse Cataract studies →Second Affiliated Hospital, Zhejiang University, School of Medicine is the lead sponsor of 99 studies on the registry; 67 are open to participants now.
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Adult patients aged 18 years or older who underwent lens surgery for lens opacity or abnormal lens position between March 1, 2024 and March 1, 2026 at the participating hospitals. Eligible surgical eyes will be identified retrospectively from medical records and classified according to whether intraoperative optical coherence tomography was used during surgery.
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Exclusion Criteria:
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A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
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Patients who underwent lens surgery using conventional surgical microscopy without intraoperative OCT.
Patients who underwent lens surgery using conventional surgical microscopy with intraoperative OCT assistance.
Device: Intraoperative Optical Coherence Tomography
Intraoperative optical coherence tomography technique can provide intraocular images and show changes in intraocular structures, assisting in analyzing the correlation between preoperative, intraoperative anterior segment structural changes and postoperative surgical effects in patients with lens diseases.
Concordance Rate Between Preoperative and Intraoperative Diagnoses
Preoperative diagnoses are determined based on routine ophthalmic examinations. Intraoperative diagnoses are determined based on surgical microscopic observations, intraoperative OCT images, and operative records. Concordance between the preoperative and intraoperative diagnoses is assessed, including whether the intraoperative diagnosis adds to or corrects the preoperative diagnosis.
Time frame: From completion of the preoperative examinations through the end of surgery; diagnostic concordance is assessed after surgery.
Intraocular Lens Tilt Angle
The tilt angle of the implanted intraocular lens is measured on intraoperative OCT images using a standardized image analysis protocol. A predefined ocular-axis reference line is used to calculate the angle between the intraocular lens axis and the reference axis.
Time frame: After intraocular lens implantation and at the end of surgery.
Incidence of Intraoperative Complications
Intraoperative complications are identified from operative records and intraoperative imaging. The incidence of each complication is calculated.
Time frame: From the start to the end of surgery.
This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Second Affiliated Hospital, Zhejiang University, School of Medicine