An observational study in Emergence Delirium, Anesthesia, sponsored by Ruijin Hospital. Enrolling by invitation at 1 site in China. Open to participants aged 60 Years and older. Per ClinicalTrials.gov, last updated 2026-08-18.
Sponsored by Ruijin Hospital · Observational
To explore the relationship between plasma orexin levels during the recovery period of elderly patients undergoing general anesthesia and the occurrence of emergence delirium, and to evaluate its sensitivity and specificity as an objective diagnostic indicator for emergence delirium
763 studies on the registry are indexed under Emergence Delirium; 241 are open to participants now.
This study's planned enrollment of 150 is close to the median of 164 across 280 observational studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Ruijin Hospital is the lead sponsor of 635 studies on the registry; 359 are open to participants now.
Counted across the registry records on this site, refreshed daily.
elderly patients undergoing general anesthesia
Exclusion Criteria:
Other: No Intervention: Observational Cohort
Other: No Intervention: Observational Cohort
No Intervention: Observational Cohort
Emergece Delirium
The CAM-ICU scale is administered at extubation and 20 minutes post-extubation during the PACU stay. A positive finding at either time point is defined as emergence delirium.
Time frame: During extubation and 20 minutes after extubation
Plasma Orexin
Peripheral venous blood samples (3 mL each) are collected at six time points: 30 minutes before anesthesia induction, after induction but before incision, 1 hour after incision, at volatile anesthetic discontinuation, at extubation, and 20 minutes post-extubation. Samples are placed in EDTA tubes, stored at 2-8°C, centrifuged at 3000 rpm for 15 minutes at 4°C, and the separated plasma is stored at -80°C. Plasma orexin-A levels are measured by ELISA by technicians blinded to group assignment.
Time frame: 30 minutes before anesthesia induction, after anesthesia induction but before surgical incision, 1 hour after surgical incision, at the time of discontinuation of volatile anesthetics, at extubation, and 20 minutes post-extubation
Postoperative Delirium
Postoperative delirium is assessed twice daily (8:00-10:00 and 18:00-20:00) from postoperative day 1 through day 5 using the CAM/CAM-ICU scale. A positive finding on any assessment is defined as the occurrence of postoperative delirium. The severity of delirium is evaluated using the DRS-R-98.
Time frame: 5 days post- operation
EEG power in alpha band
EEG power in alpha band is continuously recorded throughout the entire emergence period using the Pearlcare EEG monitor.
Time frame: From PACU admission to 20 minutes post-extubation
EEG power in beta band
EEG power in beta band is continuously recorded throughout the entire emergence period using the Pearlcare EEG monitor.
Time frame: From PACU admission to 20 minutes post-extubation
EEG power in theta band
EEG power in theta band is continuously recorded throughout the entire emergence period using the Pearlcare EEG monitor.
Time frame: From PACU admission to 20 minutes post-extubation
EEG power in delta band
EEG power in delta band is continuously recorded throughout the entire emergence period using the Pearlcare EEG monitor.
Time frame: From PACU admission to 20 minutes post-extubation
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Ruijin Hospital