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Not yet recruitingNCT07725744Updated Jul 24, 2026

Interface Pressures, Safety, Adherence, and Tactile Outcomes of Different Pressure Garments After Stroke

An interventional study of Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment and Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment in CVA (Cerebrovascular Accident) and Stroke, sponsored by National University of Malaysia. Not yet recruiting. Open to participants aged 21 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-07-24.

Sponsored by National University of Malaysia · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
33
Allocation
Randomized
Ages
21 Years to 60 Years
Sex
All
01

Study summary

This study aims to investigate the interface pressure changes of single-layer with 10% circumferential reduction (S-10), single-layer with 15% circumferential reduction (S-15), and dorsal double-layered with 10% circumferential reduction (DD-10)pressure garments over time, their relationships with adherence and adverse events, and their effects on tactile gnosis.

Participants will:

  1. Wear S-10, S-15, or DD-10 for at least 12 hours daily for four weeks
  2. Measure interface pressure at baseline and weekly
  3. Assess tactile gnosis at baseline, Week 2, and Week 4
  4. Record adherence and adverse events using a self-report logbook
02

Conditions studied

  • CVA (Cerebrovascular Accident)
  • Stroke

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Keywords

  • interface pressure
  • pressure garment
  • pressure changes
  • tactile gnosis
  • adherence
  • safety
  • Stroke Rehabilitation
  • Occupational Therapy
03

Who can participate

Ages eligible
21 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • adults aged between 21 years to 60 years old
  • a history of stroke (no restrictions on the stroke type)
  • Modified Ashworth Scale of 1, 1+ or 2 when hand performing flexion and extension
  • no cognitive impairment (Montreal Cognitive Assessment (MoCA ⩾ 21)

Exclusion criteria

Exclusion Criteria:

  • skin lesions, infections or other skin problems
  • serious circulatory problems such as deep vein thrombosis
  • hypersensitive to Lycra materials
  • behavioural disturbances or motor impairments caused by other orthopaedic or neurological conditions other than stroke
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Care provider)
Enrollment
33 participants (estimated)

Study arms

  • Active comparator
    Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

    A customized single-layered finger-to-above-elbow (long glove) pressure garment with 10% circumferential reduction.

    Other: Single-Layered 10% Circumferential Reduction (S-10) Pressure Garment

  • Experimental
    Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

    A customized finger-to-above-elbow (long glove) pressure garment with 10% of circumferential reduction. The design is similar to S-10 except it has an extra layer of fabric on the dorsal aspect that provides more compression.

    Other: Dorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

  • Active comparator
    Single-Layered 15% Circumferential Reduction (S-15) Pressure Garment

    A customized single-layered finger-to-above-elbow (long glove) pressure garment with 15% circumferential reduction.

    Other: Single-Layered 15% Circumferential Reduction (S-15) Pressure Garment

Interventions

  • OtherSingle-Layered 10% Circumferential Reduction (S-10) Pressure Garment

    Each participant will receive a single-layered 10% circumferential reduction (S-10) pressure garment, fabricated based on their circumferential measurement. Participants will receive standardized verbal and written instructions on prescribed wear schedules, donning and doffing techniques, skin inspection, and hygiene. Caregivers will be trained to assist when required. Participants will be asked to wear the pressure garment daily for at least 6 hours in the day and 6 hours in the evening for 4 weeks, and to record daily wear in a provided logbook. All participants will receive usual stroke rehabilitation in addition to the application of the pressure garment.

  • OtherDorsal-Double-Layered 10% Circumferential Reduction (DD-10) Pressure Garment

    Each participant will receive a dorsal doubled-layered 10% circumferential reduction (DD-10) pressure garment, fabricated based on their circumferential measurement. Participants will receive standardized verbal and written instructions on prescribed wear schedules, donning and doffing techniques, skin inspection, and hygiene. Caregivers will be trained to assist when required. Participants will be asked to wear the pressure garment daily for at least 6 hours in the day and 6 hours in the evening for 4 weeks, and to record daily wear in a provided logbook. All participants will receive usual stroke rehabilitation in addition to the application of the pressure garment.

  • OtherSingle-Layered 15% Circumferential Reduction (S-15) Pressure Garment

    Each participant will receive a single-layered 15% circumferential reduction (S-15) pressure garment, fabricated based on their circumferential measurement. Participants will receive standardized verbal and written instructions on prescribed wear schedules, donning and doffing techniques, skin inspection, and hygiene. Caregivers will be trained to assist when required. Participants will be asked to wear the pressure garment daily for at least 6 hours in the day and 6 hours in the evening for 4 weeks, and to record daily wear in a provided logbook. All participants will receive usual stroke rehabilitation in addition to the application of the pressure garment.

05

What researchers measure

Primary outcomes

  1. Interface pressure measured using PicoPress® Compression System

    The change in interface pressure over time and the group-by-time difference in pressure trajectories among the three pressure garment groups. PicoPress® Compression System is a portable pneumatic measuring system designed to measure interface pressure exerted by pressure garment, medical compression bandage or other compression therapeutic materials.

    Time frame: Baseline, Week-1, Week-2, Week-3, and Week-4

Secondary outcomes

  1. Shape/Texture Identification (STI) test

    A standardized, performance-based test in which participants identify shapes and textures using active touch. It consists of two subsets (i.e., identification of three shapes and identification of three textures) and three difficulty levels (i.e., shape sizes of 15, 8, and 5mm, and distances between dots of 15, 8, 4mm). Each subset is scored from 0 to 3 (one point per size), producing a total score that ranges from 0 to 6. A score of 6 points is interpreted as normal tactile gnosis.

    Time frame: Baseline, Week-2, and Week-4

  2. Daily Self-Report and Adverse Events of Special Interest (AESI) Logbook

    The self-developed logbook is a self-report records that will be used to record the adherence metrics (e.g., daily wear duration, number of days worn per week, reason of non-adherence) and the incidence of adverse events (e.g., incidence, severity, action taken).

    Time frame: Completed by participants or caregiver daily, reviewed weekly by researcher

  3. Modified Ashworth Score (MAS)

    To differentiate between mechanical garment decay and physiological fluctuations in limb volume, muscle tone (spasticity) will be monitored as a potential confounding variable.

    Time frame: Baseline, Week-1, Week-2, Week-3, and Week-4

Other outcomes

  1. Montreal Cognitive Assessment (MoCA) - Bahasa Malaysia version

    A widely used screening tool for detecting cognitive impairment, particularly mild cognitive impairment. It is a 10-minute, 30-point assessment that evaluates various cognitive domains, including working memory, delayed recall, visuospatial abilities, executive functions, attention, concentration, language, and orientation to time and place.

    Time frame: Prior to participant enrolment

  2. Modified Ashworth Score (MAS)

    A method used to assess muscle tone by a scale of 0 to 4, where 0 indicates no spasticity and 4 indicates severe spasticity.

    Time frame: Prior to participant enrolment

06

Study locations

No study locations are listed for this record.

07

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

08

Registry details

Key details

Study ID
NCT07725744
Lead sponsor
National University of Malaysia
Collaborators
SOCSO Rehabilitation Center, Malaysia
Responsible party
Sponsor
First posted
Jul 24, 2026
Start date
Jul 20, 2026 (estimated)
Primary completion
Jan 31, 2027 (estimated)
Completion
Mar 31, 2027 (estimated)
Last update
Jul 24, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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