ClinicalTrials.gg
RecruitingNCT07725198Updated Aug 28, 2026

Immediate Neuromuscular Responses of the Obliquus Capitis Inferior Following Upper Cervical Manual Therapy

An interventional study of Thrust long-axis manipulation of C1-C2 in Head and Neck and Headache, sponsored by Florida Gulf Coast University. Recruiting at 1 site in United States. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-28.

Sponsored by Florida Gulf Coast University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 1 year 2 months after the study started (first participant enrolled May 2025, registered Jul 2026).
  • Started May 2025; still recruiting 1 year 6 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
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Study summary

This study used a prospective, randomized, repeated-measures experimental design to investigate the immediate effects of two upper cervical manual therapy interventions on craniovertebral angle (CVA), clinician-perceived atlas position, and musculoskeletal ultrasound-derived obliquus capitis inferior (OCI) muscle morphology

02

Conditions studied

  • Head and Neck
  • Headache

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03

In context

Headache

762 studies on the registry are indexed under Headache; 134 are open to participants now.

This study's planned enrollment of 80 is above the median of 65 across 560 interventional studies indexed under Headache.

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Lead sponsor

Florida Gulf Coast University is the lead sponsor of 17 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • read and understand English
  • no previous history of cervical spine surgery or traumatic cervical injury
  • no to cervical manual therapy

Exclusion criteria

Exclusion Criteria:

  • any absolute to cervical manipulation
  • any other medical condition considered unsafe for manual therapy.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Contraindication

A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.

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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
80 participants (estimated)

Study arms

  • Experimental
    Long axis thrust manipulation group

    A single long axis thrust manipulation C1-C3

    Other: Thrust long-axis manipulation of C1-C2

  • Sham comparator
    Long axis thrust mobilization group

    3 x 5 second Long axis traction hold of C1-C3

    Other: Thrust long-axis manipulation of C1-C2

Interventions

  • OtherThrust long-axis manipulation of C1-C2

    One thrust manipulation is provided in the thrust group. a 5 second long axis hold traction of C1-C2 was repeated 3 times in the mobilization group

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What researchers measure

Primary outcomes

  1. MSK Ultrasound

    MSK Ultrasound measure of the Obliquues Capitis inferior muscle lenght and width

    Time frame: before intervention, immediately after, and 24 hours after intervention

Secondary outcomes

  1. Atlas position

    Atlas position relative to the head measured wth palpation of C1 transverse process

    Time frame: before intervention, immediately after, and 24 hours after intervention

  2. Craniovertebral angle

    Measure of the Craniovertebral angle using photography

    Time frame: before intervention, immediately after, and 24 hours after intervention

07

Study locations

1 of 1 sites recruiting
  • Florida Gulf Coast University Marieb Hall 101
    Fort Myers, Florida 33965, United States
    Recruiting
08

References and documents

Individual participant data

Plan to share: Yes — Information will be shared by request only

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 28, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07725198
Lead sponsor
Florida Gulf Coast University
Responsible party
Dr. Rob Sillevis, (professor, Florida Gulf Coast University) — Principal investigator
First posted
Jul 24, 2026
Start date
May 1, 2025
Primary completion
Jan 1, 2027 (estimated)
Completion
Jan 1, 2027 (estimated)
Last update
Aug 28, 2026

Study contacts

Rob Sillevis, PhD
Contact
rsillevis@fgcu.edu
239-7454312

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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