Whey Protein and Adaptogenic Supplementation in Physically Active Males

Browse trials for

• Motor Activity 2,426

Keywords

• whey protein
• ashwagandha
• physically active males
• sports supplement
• adaptogens
• exercise
• sports nutrition

Motor Activity

2,426 studies on the registry are indexed under Motor Activity; 1,161 are open to participants now.

This study's planned enrollment of 60 is close to the median of 60 across 2,118 interventional studies indexed under Motor Activity.

Lead sponsor

Sports Performance and Applied Research in Trials and Analysis is the lead sponsor of 3 studies on the registry; 2 are open to participants now.

Study arms

• Active comparator
  Whey protein

  Participants will consume a whey protein supplement daily for 6 weeks. Assessments of muscle strength, recovery, stress, wellbeing, dietary intake, and salivary biomarkers will be conducted at baseline and post-intervention.

  Dietary Supplement: Whey protein

• Experimental
  Whey Protein + Adaptogenic Blend

  Participants will consume a whey protein supplement containing ashwagandha KSM-66® (600 mg) for 6 weeks. Assessments will be conducted at baseline and post-intervention.

  Dietary Supplement: Dietary Supplement: Whey Protein With Adaptogenic Blend

Interventions

• Dietary supplementWhey protein

  Participants will consume a whey protein supplement for 6 weeks. The supplement will be provided in identical blank tubs. Participants will be instructed to maintain their usual diet and training habits throughout the intervention period.

  Also known as: Grass-Fed Whey Protein, Whey Protein Powder

• Dietary supplementDietary Supplement: Whey Protein With Adaptogenic Blend

  Participants will consume a whey protein supplement containing ashwagandha KSM-66® root extract (600 mg) for 6 weeks. Supplements will be provided in identical blank tubs. Participants will maintain usual diet and training habits during the study.

  Also known as: Whey Protein Plus Adaptogens, Ashwagandha Whey Protein

Primary outcomes

1. Salivary Cortisol Concentration

   Change in salivary cortisol concentration from baseline to post-intervention following 6 weeks of whey protein supplementation with or without an adaptogenic herb blend containing ashwagandha KSM-66®. Results will be reported in ng/mL.

   Time frame: Time Frame: Baseline and Week 6

Secondary outcomes

1. Handgrip Strength

   Change in maximal handgrip strength measured using a CAMRY dynamometer from baseline to post-intervention.

   Time frame: Time Frame: Baseline and Week 6

2. Upper Body Muscular Endurance

   Change in upper body muscular endurance assessed using the 90-degree push-up test protocol from baseline to post-intervention.

   Time frame: Time Frame: Baseline and Week 6

3. Perceived Recovery and Wellbeing

   Participants will complete the Hooper Index Questionnaire, which assesses four domains: sleep quality, fatigue, stress, and muscle soreness. Each domain is rated on a 10-point Likert scale ranging from 1 to 10, with total scores ranging from 4 to 40. Higher scores indicate poorer wellbeing and recovery status, whereas lower scores indicate better perceived wellbeing and recovery.

   Time frame: Time Frame: Baseline and Week 6

4. Salivary DHEA-S Concentration

   Salivary DHEA-S concentration will be measured from saliva samples using enzyme-linked immunosorbent assay (ELISA) techniques. Results will be reported in ng/mL.

   Time frame: Time Frame: Baseline and Week 6

5. Dietary Intake

   Dietary intake assessed using a 24-hour dietary recall to evaluate habitual nutritional intake during the study period.

   Time frame: Time Frame: Baseline and Week 6

6. Salivary Testosterone Concentration

   Salivary testosterone concentration will be measured from saliva samples using ELISA. Results will be reported in pg/mL.

   Time frame: Time Frame: Baseline and Week 6

7. Salivary Secretory Immunoglobulin A (sIgA) Concentration

   Salivary secretory immunoglobulin A (sIgA) concentration will be measured from saliva samples using ELISA. Results will be reported in µg/mL.

   Time frame: Time Frame: Baseline and Week 6

8. Salivary C-reactive Protein Concentration

   Salivary C-reactive protein will be measured from saliva samples using ELISA. Results will be reported in pg/mL.

   Time frame: Time Frame: Baseline to Week 6

Individual participant data

Plan to share: No — Individual participant data (IPD) will not be shared with other researchers. Data collected in this study will be anonymised and retained only for the duration of analysis before permanent deletion, in accordance with the study protocol, participant consent, and UK GDPR requirements.