An observational study in Pigmentary Glaucoma, sponsored by Zhongnan Hospital. Recruiting at 1 site in China. Open to participants aged 16 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-07-20.
Sponsored by Zhongnan Hospital · Observational
This study aims to investigate the clinical characteristics of pigmentary glaucoma and evaluate the efficacy and safety of ab-interno 120° trabeculotomy during the 6-month postoperative follow-up period.
This is a single-center, retrospective case series study. Patients with pigmentary glaucoma treated at Zhongnan Hospital of Wuhan University will be enrolled. By systematically collecting their baseline demographic characteristics, ocular examination results, and prior treatment history, the study aims to summarize the distribution pattern of clinical features of pigmentary glaucoma. With the 6-month postoperative follow-up as the primary endpoint, the study will evaluate the intraocular pressure-lowering effect of ab-interno 120° trabeculotomy, changes in medication dependence, and the stability of visual field and retinal nerve fiber layer, while observing the occurrence of related intraoperative and postoperative complications, so as to provide clinical evidence for individualized surgical treatment of pigmentary glaucoma.
924 studies on the registry are indexed under Glaucoma, Open-Angle; 117 are open to participants now.
This study's planned enrollment of 11 is below the median of 101 across 184 observational studies indexed under Glaucoma, Open-Angle.
Browse Glaucoma, Open-Angle studies →Zhongnan Hospital is the lead sponsor of 106 studies on the registry; 49 are open to participants now.
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This study included patients with pigmentary glaucoma who underwent primary isolated ab-interno 120° trabeculotomy at Zhongnan Hospital of Wuhan University. All patients had complete baseline data (including intraocular pressure, visual field, and OCT retinal nerve fiber layer measurements) and at least 6 months of follow-up data. Patients with other types of glaucoma, prior ocular trauma or surgery history, combined intraoperative procedures, severe systemic diseases, or incomplete key data were excluded.
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Exclusion Criteria:
A minimally invasive glaucoma surgery (MIGS) procedure performed via an ab interno approach, involving a 120-degree incision of the trabecular meshwork to improve aqueous humor outflow.
Change in Intraocular Pressure (IOP) at 6 Months Postoperatively
Change in intraocular pressure from baseline to 6 months after ab-interno 120° trabeculotomy, including the mean IOP level, absolute reduction, and percentage reduction relative to baseline.
Time frame: 6 months postoperatively
Change in the Number of Intraocular Pressure-Lowering Medications at 6 Months
Change in the number of glaucoma medications used by patients, comparing baseline to 6 months after surgery.
Time frame: 6 months postoperatively
Changes in Visual Field Parameters at 6 Months Postoperatively
Changes in visual field mean deviation (MD) from baseline to 6 months postoperatively.
Time frame: 6 months postoperatively
Changes in Visual Field Parameters at 6 Months Postoperatively
Changes in pattern standard deviation (PSD) from baseline to 6 months postoperatively.
Time frame: 6 months postoperatively
Changes in Visual Acuity at 6 Months Postoperatively
Changes in best-corrected visual acuity (BCVA) from baseline to 6 months postoperatively.
Time frame: 6 months postoperatively
Status of Trabeculotomy Site on Gonioscopy
Patency and morphological status of the trabecular meshwork incision site as assessed by gonioscopy at 6 months postoperatively.
Time frame: 6 months postoperatively
Improvement in Pupillary Block and Iris Configuration
Improvement in pupillary block and iris configuration as assessed by anterior segment optical coherence tomography (OCT) at 6 months postoperatively.
Time frame: 6 months postoperatively
Rate of Secondary Glaucoma Surgery
Proportion of patients who require additional glaucoma surgery during the 6-month follow-up period.
Time frame: From the day of surgery to 6 months postoperatively
Plan to share: Undecided
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