An observational study in Ataxia Telangiectasia, sponsored by University of Nottingham. Not yet recruiting. Open to participants aged 0 Years to 5 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-16.
Sponsored by University of Nottingham · Observational
The goal of this observational study is to identify progressive changes of quantitative brain and lung imaging, serum and movement-related biomarkers reflecting disease progression in pre-symptomatic infants and very young children (0-5 yo) with a genetic diagnosis of A-T, that could be used in future early-life intervention trials.
42 studies on the registry are indexed under Ataxia Telangiectasia; 7 are open to participants now.
This study's planned enrollment of 56 is close to the median of 60 across 12 observational studies indexed under Ataxia Telangiectasia.
Browse Ataxia Telangiectasia studies →University of Nottingham is the lead sponsor of 465 studies on the registry; 80 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants with A-T will be recruited principally via the National Paediatric A-T Clinic based at Nottingham University Hospitals NHS Trust. A second route for recruitment is the A-T Society, a UK charity that provides support and advocacy for people with A-T and their families.
Participants without A-T or other conditions described in the exclusion criteria, will be infants and young children undergoing general anaesthesia at Nottingham University Hospitals NHS Trust for minor surgical procedures (e.g. circumcision, orchidopexy) or diagnostic MRI.
Participants with A-T
Inclusion criteria
Exclusion criteria
NB - co-recruitment to other observational studies or trials is permitted. If a family chooses to enrol their child in an interventional study targeting neurodegeneration, provided that the intervention trial allows co-recruitment, we would like to retain the participant in the BOBCAT study until its conclusion. In this circumstance, the child's data would not be considered as part of the natural history dataset but would instead be used to demonstrate the feasibility of collecting longitudinal quantitative imaging and other biomarker data in people with A-T during infancy and early childhood.
Participants without A-T
Inclusion criteria
Exclusion criteria
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Up to 4 longitudinal visits, depending on enrolment window Brain MRI/Assessment/Movement Quantitative Analysis/Blood Test
One single visit Blood test only
Brain MRI - Volumetric structural T1-weighted (T1)
Volume (mm³) - Acquisition parameters aligned to HEALthy Brain and Child Development Study (HBCD)
Time frame: Up to 4 years ( last visit)
Brain MRI - Magnetic Resonance Spectroscopy (MRS): quantification of N-acetyl aspartate in the cerebellum
Chemical shift (ppm) - Acquisition parameters aligned to HEALthy Brain and Child Development Study (HBCD)
Time frame: Up to 4 years ( last visit)
Brain MRI - Diffusion Weighted Imaging (DWI)
Apparent Diffusion Coefficient (mm²/s) - Acquisition parameters aligned to HEALthy Brain and Child Development Study (HBCD)
Time frame: Up to 4 years ( last visit)
Neurological and developmental assessment
* A-TNEST test * Denver Developmental Screening Test II (DDST)
Time frame: Up to 4 years ( last visit)
Quantitative movement analysis
Quantitative analysis of limb, facial and eye movements will be made using a machine learning approach.
Time frame: Up to 4 years ( last visit)
Serum markers of neurodegeneration
* Neurofilament light chain (NFL) * Glial fibrillary acidic protein (GFAP)
Time frame: Up to 4 years ( last visit)
Lung MRI
• Lung MRI metrics, feasibility, and the results of the quantitative analyses, where it has been possible to do this. * free-breathing proton-based ventilation * structural images using the proton-based techniques
Time frame: Up to 4 years ( last visit)
Natural sleep MRI procedure
Completion rates (%) and image quality (Signal-to-Noise Ratio, SNR, and Contrast-to-Noise Ratio CNR - unitless ) when using the sleep MRI protocol
Time frame: Up to 4 years ( last visit)
No study locations are listed for this record.
Start is estimated for Sep 2026; primary completion for Aug 2029, 35 months later.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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