An observational study in Knee Osteoarthritis and Osteoarthritis, Knee, sponsored by Antalya Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Per ClinicalTrials.gov, last updated 2026-07-15.
Sponsored by Antalya Training and Research Hospital · Observational
The purpose of this study is to investigate the relationship between the clinical and radiographic severity of knee osteoarthritis (OA) and the serum levels of specific biomarkers, namely Fetuin-A and Cartilage Oligomeric Matrix Protein (COMP). Osteoarthritis is a degenerative joint disease characterized by cartilage breakdown and low-grade inflammation. Investigating these biomarkers may help healthcare providers better understand the disease pathology, potentially leading to earlier diagnosis and improved tracking of disease progression. The study will compare two distinct groups: a patient group consisting of 120 individuals diagnosed with Grade 2-4 knee osteoarthritis, and a control group of 60 age- and sex-matched healthy volunteers with no history of joint disorders. Participants will undergo radiographic evaluations using the Kellgren-Lawrence classification system, alongside clinical and functional assessments, including pain severity scales, mobility metrics, and functional questionnaires. Fasting blood samples will be collected from all participants to measure serum Fetuin-A and COMP levels via laboratory analysis, and the Systemic Inflammation Response Index (SIRI) will be calculated. The collected data will be statistically analyzed to determine if biomarker levels significantly correlate with the severity of knee joint degeneration and functional impairment.
3,292 studies on the registry are indexed under Osteoarthritis, Knee; 623 are open to participants now.
This study's planned enrollment of 180 is above the median of 100 across 486 observational studies indexed under Osteoarthritis, Knee.
Browse Osteoarthritis, Knee studies →Antalya Training and Research Hospital is the lead sponsor of 104 studies on the registry; 12 are open to participants now.
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The study population consisted of two main groups: a patient group and a healthy control group. The patient group included individuals who presented to the Physical Medicine and Rehabilitation Outpatient Clinics of SBÜ Antalya Training and Research Hospital and were diagnosed with primary knee osteoarthritis (Stage 2-4 according to the Kellgren-Lawrence classification system). The control group consisted of healthy volunteers of similar age and gender who did not have a known joint disorder, a history of knee pain, or a systemic inflammatory disease. All participants were selected using a single-center, hospital-based convenience sampling method during the specified study period.
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- Diagnosis of knee osteoarthritis according to ACR (American College of Rheumatology) criteria. Knee osteoarthritis classified as Grade 2, 3, or 4 according to Kellgren-Lawrence (K-L) grading. Volunteering to participate and providing signed .
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
120 patients diagnosed with primary knee osteoarthritis (Grade 2-4 according to Kellgren-Lawrence classification, 40 patients from each grade).
60 age- and sex-matched healthy volunteers without any knee pain, history of joint disease, or systemic inflammatory conditions.
Serum Fetuin-A Levels
Measurement of serum Fetuin-A concentration using a human-specific ELISA kit to evaluate its relationship with radiographic and clinical severity.
Time frame: Baseline (At the time of enrollment / single time point measurement)
Serum COMP (Cartilage Oligomeric Matrix Protein) Levels
Time frame: Baseline
Radiographic Severity via Kellgren-Lawrence (K-L) Classification
Time frame: Baseline
Clinical Severity and Functional Status via WOMAC Index
Time frame: Baseline
Systemic Inflammation Response Index (SIRI)
(Neutrophil x Monocyte) / Lymphocyte
Time frame: Baseline
Pain Severity via Visual Analog Scale (VAS)
Time frame: Baseline
Functional Mobility via 10-Meter Walk Test (10MWT)
Time frame: Baseline
Lower Extremity Muscle Strength via 5-Times Sit-to-Stand Test (5x STS)
Time frame: Baseline
Started Apr 2026 (actual). Primary completion is estimated for Aug 2026, 4 months after the start.
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