An interventional study of Corticosteroid and Standard endodontic treatment in Periapical Periodontitis, sponsored by Istanbul Medipol University Hospital. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-15.
Sponsored by Istanbul Medipol University Hospital · Not applicable, Interventional, and Diagnostic
This randomized clinical trial compared standard single-visit root canal treatment with adjunctive submucosal betamethasone and gentamicin in 100 patients with symptomatic irreversible pulpitis, assessing postoperative pain and inflammatory biomarkers (IL-1β, MMP-9, and RANKL).
This study was designed as a prospective, randomized controlled clinical trial. A total of 100 patients with a VAS pain score ≥7 and SIP in posterior teeth were included. Participants were randomly assigned into two groups: a standard root canal treatment group (n = 40) and an adjunctive treatment group receiving submucosal betamethasone and gentamicin (n = 60). In all cases, conventional single-visit root canal treatment was performed. Gingival crevicular fluid (GCF) samples were collected preoperatively and on postoperative day 3, and VAS scores were recorded at the same time points. Levels of IL-1β, MMP-9, and RANKL in GCF samples were quantified using enzyme-linked immunosorbent assay (ELISA).
246 studies on the registry are indexed under Periapical Periodontitis; 64 are open to participants now.
This study's enrollment of 100 is above the median of 60 across 210 interventional studies indexed under Periapical Periodontitis.
Browse Periapical Periodontitis studies →Istanbul Medipol University Hospital is the lead sponsor of 350 studies on the registry; 58 are open to participants now.
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Exclusion Criteria:
Patients in this group will undergo traditional root canal treatment under local anesthesia.
Other: Standard endodontic treatment
Patients in this group will receive submucosal injections following local anesthesia: * Betamethasone * Gentamicin Then, root canal treatment will be performed in the same way as the control group.
Drug: Corticosteroid
One hundred patients were randomly assigned to either the standard treatment group receiving conventional root canal treatment (control, n = 40) or the adjunctive treatment group receiving conventional root canal treatment combined with submucosal betamethasone and gentamicin injection (n = 60) by the Research Randomizer programme (accessed at www.randomizer.org).
standard treatment group receiving conventional root canal treatment
Gingival Crevicular Fluid Matrix Metalloproteinase-9 (MMP-9) Concentration
MMP-9 levels in gingival crevicular fluid will be quantified using enzyme-linked immunosorbent assay (ELISA).
Time frame: Baseline and post-treatment day 3
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Istanbul Medipol University Hospital