An interventional study of Laser genicular nerve ablation and Conventional radiofrequency genicular nerve ablation in Analgesia, sponsored by Zagazig University. Not yet recruiting. Open to participants aged 40 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-14.
Sponsored by Zagazig University · Not applicable, Interventional, and Treatment
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterised by progressive cartilage degeneration, subchondral bone remodelling, and synovial inflammation.
There were many trails to provide pain relief by using systemic opioids or Non steroidal anti inflammatory drugs (with side effects such as peptic ulcer and hepatic, renal impairment)
Knee osteoarthritis is one of the most common causes of chronic pain and disability worldwide, particularly in middle-aged and elderly populations. It is characterized by progressive cartilage degeneration, subchondral bone remodeling, and synovial inflammation.
There were many trails to provide pain relief by using systemic opioids or non steroidal anti inflammatory drugs (with side effects such as peptic ulcer and hepatic, renal impairment) In knee osteoarthritis .these nerves are believed to be sensitised, leading to increased pain signalling . This can result in chronic pain and discomfort in patients with knee osteoarthritis.
Radiofrequency targeting these nerves aims to provide pain relief by disrupting the pain signals transmitted through these nerves .
By selectively targeting the articular branches, these interventions can alleviate pain and improve the physical function and quality of life of patients with knee osteoarthritis. The positive therapeutic effect of radiofrequency on genicular nerves has been reported in many previous studies . However, little is known about its effects on patients with intractable knee pain.
Exclusion Criteria:
Laser genicular nerve ablation Using ultrasound
Procedure: Laser genicular nerve ablation
Conventional Radiofrequency genicular nerve ablation using ultrasound
Procedure: Conventional radiofrequency genicular nerve ablation
Ultrasoud guided Laser genicular nerve ablation for pain relief in knee osteoarthritis
Conventional radiofrequency genicular nerve ablation for pain relief in knee osteoarthritis
Visual Analogue scale pain score
To assess pain intensity using Visual Analogue Scale score between laser and radiofrequency group with score 10 indicates worst pain and score 0 indicates no pain.
Time frame: 24 hour
No study locations are listed for this record.
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Zagazig University