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CompletedNCT07700394Updated Jul 15, 2026

Different Treatment Options For Mature Teeth With Apical Periodontitis

An interventional study of root canal treatment and intracanal medicament and Regeneration in Apical Periodontitis, sponsored by Sara Tariq Elemam. Completed at 1 site in Egypt. Open to participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-15.

Sponsored by Sara Tariq Elemam · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 4 years 7 months after the study started (first participant enrolled Dec 2021, registered Jul 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 30 Years
Sex
All
01

Study summary

A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis:

Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

02

Conditions studied

  • Apical Periodontitis
03

In context

Periapical Periodontitis

246 studies on the registry are indexed under Periapical Periodontitis; 64 are open to participants now.

This study's enrollment of 30 is below the median of 60 across 211 interventional studies indexed under Periapical Periodontitis.

Browse Periapical Periodontitis studies →

Lead sponsor

This is the only study on the registry with Sara Tariq Elemam as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 30 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Patients aged 18-30 years
  • Healthy patients with no systemic diseases or known allergic reactions
  • Mature permanent molars diagnosed with pulp necrosis
  • Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5)

Exclusion criteria

Exclusion Criteria:

  • Patients with generalized chronic periodontitis
  • Presence of small periapical lesions (PAI=1,2)
  • Periodontal pockets > 3 mm
  • Presence of systemic diseases or known hypersensitivity to any material used in the study
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
30 participants (actual)

Study arms

  • Active comparator
    Conventional RCT

    Procedure: root canal treatment and intracanal medicament

  • Experimental
    RET using a BMPs

    Procedure: Regeneration with BMPs

  • Experimental
    Regenerative endodontic treatment

    Procedure: Regeneration

Interventions

  • Procedureroot canal treatment and intracanal medicament

    conventional root canal treatment with obturation

  • ProcedureRegeneration

    Regeneration using induction of bleeding

  • ProcedureRegeneration with BMPs

    RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

06

What researchers measure

Primary outcomes

  1. Healing in terms of volumetric change of lesion analyzed by CBCT

    Time frame: 1 year

07

Study locations

1 site
  • Faculty of dentistry ain shams university
    Cairo, Egypt
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 15, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07700394
Lead sponsor
Sara Tariq Elemam
Responsible party
Sara Tariq Elemam (Doctor, Ain Shams University) — Sponsor-investigator
First posted
Jul 14, 2026
Start date
Dec 1, 2021
Primary completion
Apr 1, 2026
Completion
Apr 1, 2026
Last update
Jul 15, 2026

Study contacts

Shehab El Din Mohamed Saber, PHD
study director · Faculty of dentistry Ain Shams University

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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