An interventional study of Home-Based Exercise Program and Semi-Vegetarian Diet in Obesity, Metabolic Changes and Hormonal Changes, sponsored by Firat University. Completed at 1 site in Turkey (Türkiye). Open to female participants aged 19 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-10.
Sponsored by Firat University · Not applicable, Interventional, and Treatment
This study investigates the effects of different dietary strategies (ketogenic diet, intermittent fasting, and semi-vegetarian diet), alone or in combination with a structured home-based exercise program, on anthropometric, metabolic, and hormonal parameters in women with obesity. A total of 108 participants aged 19-45 years are allocated into nine groups, including control, exercise-only, diet-only, and combined intervention groups. Anthropometric outcomes (body weight, body mass index, and body fat percentage) and biochemical markers (glucose, insulin, adiponectin, IGF-1, irisin, and myostatin) are assessed at baseline and after a 6-week intervention period using bioelectrical impedance analysis and ELISA methods.
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's enrollment of 108 is above the median of 67 across 9,006 interventional studies indexed under Obesity.
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Exclusion Criteria:
This group consists of 12 individuals with normal weight who do not receive any dietary or exercise interventions. They maintain their habitual lifestyle, physical activity, and dietary patterns for 6 weeks.
This group consists of 12 individuals with obesity who do not receive any dietary or exercise interventions. They maintain their regular lifestyle, physical activity, and dietary habits for 6 weeks.
This group consists of 12 individuals with obesity who participate in a structured home-based exercise program for 6 weeks, without any dietary modifications.
Behavioral: Home-Based Exercise Program
This group consists of 12 individuals with obesity who follow a structured semi-vegetarian dietary protocol combined with a home-based exercise program for 6 weeks.
Behavioral: Home-Based Exercise Program · Other: Semi-Vegetarian Diet
This group consists of 12 individuals with obesity who follow a structured semi-vegetarian dietary protocol for 6 weeks, without participating in any exercise program.
Other: Semi-Vegetarian Diet
This group consists of 12 individuals with obesity who follow a structured intermittent fasting protocol combined with a home-based exercise program for 6 weeks.
Behavioral: Home-Based Exercise Program · Other: Intermittent Fasting
This group consists of 12 individuals with obesity who follow a structured intermittent fasting protocol for 6 weeks, without participating in any exercise program.
Other: Intermittent Fasting
This group consists of 12 individuals with obesity who follow a structured ketogenic dietary protocol combined with a home-based exercise program for 6 weeks.
Behavioral: Home-Based Exercise Program · Other: Ketogenic Diet
This group consists of 12 individuals with obesity who follow a structured ketogenic dietary protocol for 6 weeks, without participating in any exercise program.
Other: Ketogenic Diet
A 6-week structured home-based exercise program consisting of moderate-intensity activities designed for weight management and metabolic improvement.
Also known as: Structured Physical Exercise
A 6-week structured semi-vegetarian dietary protocol primarily based on plant foods with occasional inclusion of meat or fish, designed for caloric control and metabolic tracking.
Also known as: Flexitarian Dietary Intervention
A 6-week structured intermittent fasting protocol regulating specific eating and fasting windows each day to evaluate its effects on body composition and metabolic markers.
Also known as: Time-Restricted Feeding (TRF)
A 6-week structured ketogenic dietary protocol characterized by high-fat, adequate-protein, and very low-carbohydrate intake to induce nutritional ketosis.
Also known as: Very Low-Carbonhydrate Ketogenic Diet (VLCKD)
Change in Body Weight
Body weight will be measured in kilograms (kg) using a calibrated Bioelectrical Impedance Analysis (BIA) device (Omron Karadascan HBF-511, Japan). The outcome will evaluate the effectiveness of the 6-week lifestyle interventions on body mass reduction compared to baseline.
Time frame: Baseline and 6 weeks
Change in Body Mass Index (BMI)
Body Mass Index will be calculated using the formula weight in kilograms divided by height in meters squared (kg/m²). Height will be measured using a stadiometer (Holtain Ltd., UK) and weight via a Bioelectrical Impedance Analysis (BIA) device (Omron Karadascan HBF-511, Japan).
Time frame: Baseline and week 6
Change in Body Fat Percentage
Body fat percentage (%) will be measured using a Bioelectrical Impedance Analysis (BIA) device (Omron Karadascan HBF-511, Japan) to evaluate the proportion of fat tissue relative to total body weight.
Time frame: Baseline and week 6
Change in Skeletal Muscle Percentage
Skeletal muscle percentage (%) will be measured using a Bioelectrical Impedance Analysis (BIA) device (Omron Karadascan HBF-511, Japan) to evaluate the proportion of muscle tissue relative to total body weight.
Time frame: Baseline and week 6
Change in Fasting Blood Glucose
Fasting blood glucose levels will be analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) method from venous blood samples to evaluate the effects of the interventions on glycemic control.
Time frame: Baseline and week 6
Change in Fasting Insulin
Fasting insulin levels will be analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) method from venous blood samples to assess pancreatic beta-cell function and insulin dynamics.
Time frame: Baseline and week 6
Change in Adiponectin Levels
Serum adiponectin levels will be analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) from venous blood samples to evaluate changes in adipokine secretion and insulin sensitivity.
Time frame: Baseline and week 6
Change in Insulin-Like Growth Factor 1 (IGF-1) Levels
Serum IGF-1 levels will be analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) from venous blood samples to evaluate alterations in growth hormone axis and metabolic adaptation.
Time frame: Baseline and week 6
Change in Irisin Levels
Serum irisin levels will be analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) from venous blood samples to track changes in myokine secretion in response to physical activity and dietary interventions.
Time frame: Baseline and week 6
Change in Myostatin Levels
Serum myostatin levels will be analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) from venous blood samples to assess skeletal muscle mass regulation and myokine alterations.
Time frame: Baseline and week 6
PDFs hosted by the registry, ClinicalTrials.gov.
Plan to share: No — İndividual participant data will not be shared because participant consent for public data sharing was not obtained.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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