An observational study in Dandruff, sponsored by Zentrela Inc.. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-07-06.
Sponsored by Zentrela Inc. · Observational
The goal of this clinical trial is to learn whether regular use of Nizoral® Daily Prevent shampoo and conditioner can improve scalp comfort, sleep experiences, mood, and overall well-being in adults who have scalp discomfort and difficulty sleeping. The main questions it aims to answer are:
Participants completed a one-week period without hair products, followed by two weeks of using the study shampoo and conditioner at least three times per week. During the study, participants:
This was a prospective, single-arm, observational study evaluating the effects of regular use of a cosmetic shampoo and conditioner on scalp comfort, sleep-related experiences, mood, and neurophysiological responses in adults reporting scalp discomfort and sleep difficulties.
Participants were recruited from an internal volunteer database and screened against predefined eligibility criteria. All participants provided written informed consent before any study procedures.
The study consisted of four weekly visits: a baseline visit (EEG, scalp and sleep questionnaires, initiation of Fitbit sleep monitoring), a washout visit one week later with no hair products, followed by two further visits assessing early and extended effects after approximately one and two weeks of product use, respectively. Daily sleep monitoring and weekly questionnaires continued throughout.
EEG recordings were analyzed using Cognalyzer® EEG-based metrics, including mood valence, relaxation, sleepiness, anger, and mental arousal. The primary objective was to evaluate changes in neurophysiological and self-reported measures of scalp comfort, sleep experiences, mood, and well-being following product use; exploratory objectives included sleep-related outcomes and EEG-derived indicators of emotional and cognitive state.
Zentrela Inc. is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Participants were recruited from an existing volunteer database maintained by the research site in Hamilton, Ontario, Canada. The study population consisted of community-dwelling adults interested in participating in consumer product research. Recruitment was conducted through database outreach and screening questionnaires. Participants were selected from the local community and represented a range of ages and both sexes.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: Cosmetic Shampoo and Conditioner Regimen
Participants used the study cosmetic shampoo together with the study cosmetic conditioner at least three times per week for two consecutive weeks, following a one-week washout period without hair products.
Change in EEG-Derived Mood Valence
EEG-derived mood valence, reflecting positive versus negative emotional state, compared between baseline visits (1-2) and product-use visits (3-4).
Time frame: Up to 4 weeks
Change in EEG-Derived Relaxation Level
EEG-derived relaxation level compared between baseline and product-use visits.
Time frame: Up to 4 weeks
Change in EEG-Derived Sleepiness Level
EEG-derived sleepiness indicators compared between baseline and product-use visits.
Time frame: Up to 4 weeks
Change in EEG-Derived Anger Level
EEG-derived anger-related response compared between baseline and product-use visits.
Time frame: Up to 4 weeks
Change in Self-Reported Scalp Comfort
Weekly questionnaire measures of scalp itch and discomfort compared between baseline and product-use periods.
Time frame: Up to 4 weeks
Change in Self-Reported Sleep Quality
Weekly questionnaire measures of sleep onset, night-time waking, and feeling rested, compared between baseline and product-use periods.
Time frame: Up to 4 weeks
Change in Fitbit-Measured Sleep Parameters
Wearable-derived sleep metrics collected nightly, compared between baseline and product-use periods.
Time frame: Up to 4 weeks
Plan to share: No — Individual participant data collected during this study, including electroencephalography (EEG), questionnaire, and wearable device data, will not be made available to other researchers. The study was conducted as a sponsor-supported consumer product research study, and there is no plan to share de-identified participant-level datasets or supporting data dictionaries outside the study team.
This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Dandruff
Zentrela Inc.