An interventional study of baduanjin exercise and elastic band exercises in Mild Cognitive Impairment (MCI), sponsored by qiu chen. Not yet recruiting. Open to participants aged 60 Years to 74 Years. Per ClinicalTrials.gov, last updated 2026-06-18.
Sponsored by qiu chen · Not applicable, Interventional, and Treatment
Previous studies have confirmed that both acute (single) and long-term various exercise interventions can significantly improve the cognitive function of individuals with MCI. The positive effects of long-term Qigong and elastic band exercises have also been verified. There are relatively few studies on the impact of Qigong and elastic band exercises on working memory. Most studies focusing on working memory mainly target children and college students. The effect of these exercises on the elderly has not been proven, and the improvement mechanism has not been clarified either. This article mainly starts from a single exercise perspective to explore whether a single exercise can improve the VSWM of elderly individuals with MCI. From the perspective of neurophysiology, it also discusses the brain mechanism of single Qigong and elastic band exercises on the working memory of cognitively impaired elderly people, providing reference for future long-term exercise prescriptions for the treatment and prevention of Alzheimer's disease in China.
3,843 studies on the registry are indexed under Cognitive Dysfunction; 1,100 are open to participants now.
This study's planned enrollment of 60 is close to the median of 65 across 2,808 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →This is the only study on the registry with qiu chen as lead sponsor.
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- Include the elderly population aged between 60 and 74 years old.
- Includes individuals with cognitive impairments. The patients or informants report experiencing memory decline and having certain cognitive dysfunction (MoCA score = 18-25 points).
- Including individuals who have controlled diabetes and/or cardiovascular diseases to a stable state.
- Irregular exercise with the ability to complete a certain amount of physical activities.
- Normal vision and hearing.
Exclusion Criteria:
- Patients with moderate to severe cognitive impairment, mental illness or other neurodegenerative diseases (such as Parkinson's dementia, stroke, frontotemporal degeneration, vascular dementia, Lewy body dementia, etc.).
- Long-term or recent use of psychotropic drugs, drugs that affect physical activity ability, cholinergic inhibitors, etc.
- Regular exercise habit .
- There are serious muscle disorders, or there has been an injury to the lower limbs within the previous six months, making it impossible to stand for a long time or to stand at all.
- Severe cardiovascular disease.
Other: baduanjin exercise
Other: elastic band exercises
Perform the 30-minute Baduanjin exercise
Perform 30 minutes of elastic band exercises
visuo-spatial working memory
The primary research outcome pertains to visuospatial working memory, which is measured through a visuospatial working memory task paradigm. The specific paradigm is as follows: First, a "+" appears in the middle of a gray computer screen for 300 ms. Second, a 4x4 grid matrix appears at the center of the screen for 2000 ms, with 5 small black squares randomly placed within the matrix. Immediately afterwards, a blank screen is presented for 3000 ms. During this period, the participants are required to mentally visualize the probe stimulus after rotating it 90° to the left (or right). Subsequently, a 4x4 grid target stimulus is presented again for 4000 ms, and the participants need to make a judgment on the target stimulus, specifically whether it is the result of rotating the probe stimulus 90° to the left (or right), as shown in Figure 3. The entire experiment lasts approximately 8 minutes.
Time frame: From July 1, 2026, to September 1, 2026, the duration is two months.
EEG power value
The testers adjusted the impedance to below 5kΩ and followed the 26-system electrode placement method specified by the International Federation of Electroencephalography. They set Fp1, Fp2, F3, F4, F7, F8, Fc3, Fc4, C3, C4, Cp3, Cp4, P3, P4, Pz, O1, O2, Oz, Po3, Po4, T3, T4, T5, and T6 leads. The ground electrode was set as GND, and the reference electrode was at the bilateral earlobe positions of A1 and A2. After stabilization, they began to record the EEG signals for 5 minutes. Using the toolbox, they filtered out data segments with obvious artifact interference. They analyzed the EEG indicators, including frontal cortex δ-β2 (Fp1, Fp2, F3, F4, F7, F8, AF3, AF4, Fc3, Fc4), central cortex δ-β2 (C3, C4, Cp3, Cp4), parietal cortex δ-β2 (P3, P4, Pz), occipital cortex δ-β2 (O1, O2, Oz, Po3, Po4), and temporal cortex δ-β2 (T3, T4, T5, T6).
Time frame: The total duration was two months.
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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