An observational study in Heart Failure, NYHA Class II Heart Failure and NYHA Class III Heart Failure, sponsored by The Cleveland Clinic. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by The Cleveland Clinic · Observational
Emerging evidence links ultra processed foods (UPFs) to adverse cardiovascular outcomes. UPFs are often high in sodium, unhealthy fats and added sugars, while being low in essential nutrients and fiber. UPFs contribute to systemic inflammation, fluid retention, and metabolic dysfunction-key drivers of HF and kidney disease progression. Traditional dietary counseling often lacks specificity around food processing levels. Furthermore, the majority of nutrition studies relied on extensive self-reported dietary recall food frequency questionnaires (FFQ) that are subjective, often labor intensive, and difficult to implement practically in the clinical setting. As such, researchers have developed metabolite scores from blood and urine samples to help quantify UPF consumption, which has the promise to better guide dietary counseling and track process. Therefore, the aim of this study is to evaluate the feasibility and physiological impact of a structured UPF-reduction dietary intervention in patients with HF, leveraging both digital dietary tools (Cronometer) and biomarker assessments.
Adults with NYHA Class II-III Heart Failure willing and able to track their diet using a mobile app.
Exclusion Criteria:
Participants in this study will be advised on ways to limit UPF in their diet for a period of 28 days. There is no specific diet to follow. Instead, researchers will ask participants to track what they eat in a mobile app (Cronometer) with the aim of reducing UPF consumption.
Document Ultraprocessed Food (UPF) Consumption in HF
To improve understanding of UPF consumption (type(s), amount(s), etc.) in patients with heart failure
Time frame: 5 years
Change in ultraprocessed food (UPF) consumption in heart failure patients
To investigate the potential for reducing UPF consumption via dietary counseling, Cronometer tracking, and structured patient feedback.
Time frame: 5 Years
Plan to share: No — Data will only be shared in aggregate and deidentified.
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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The Cleveland Clinic