An interventional study of EXERCISE TRAINING WITH OR WITHOUT MEDICATION and education in Asthma Childhood, Exercise and Children, sponsored by University of Leicester. Not yet recruiting at 1 site in United Kingdom. Open to participants aged 10 Years to 17 Years. Per ClinicalTrials.gov, last updated 2026-06-11.
Sponsored by University of Leicester · Not applicable, Interventional, and Prevention
What is this study about? The investigators want to see if exercise and education sessions can help children and young people (aged 10-17) with asthma, manage the participants asthma better.
The investigators will place participants that are recruited to this study into one of three groups by a computer (randomly):
Group 1:
Usual Care: Continue with normal asthma treatment.
Group 2:
Education: Usual care + a 45-minute online asthma education class once a week.
Group 3:
Exercise \& Education: Usual care + 3 exercise sessions a week and asthma education classes.
This research aims to identify if an exercise and/or asthma education programme, called 'Active Airways', is feasible and acceptable in the paediatric asthma patient. Feasibility, the primary outcome of this study, will be evaluated by calculating the percentage of people approached who participate in the intervention (recruitment) and the percentage who complete the intervention (retention and adherence). The investigators also want to see if the Active Airways programme could improve cardiorespiratory fitness, quality of life and lung function, reduce asthma attacks and reduce healthcare use.
4,841 studies on the registry are indexed under Asthma; 600 are open to participants now.
This study's planned enrollment of 60 is below the median of 78 across 3,341 interventional studies indexed under Asthma.
Browse Asthma studies →University of Leicester is the lead sponsor of 170 studies on the registry; 51 are open to participants now.
Compared within Asthma, this study's primary condition as ClinicalTrials.gg classifies it; the registry's first condition term is Motor Activity. The counts are of registry records indexed under each term, refreshed daily. How we classify →
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Willing and able to consent to participate in the trial
Able to understand written and spoken English
A diagnosis of Mild to Moderate Asthma or Severe Asthma based on the European Respiratory Society (ERS)/ American Thoracic Society (ATS) consensus statement on Severe Asthma
Able to participate in a formal exercise programme
Aged 10-17 years
Able to engage in focus groups
Approximately 130cm tall (to be able to complete cardiopulmonary exercise testing (CPET))
Exclusion Criteria:
Self-reported uncontrolled severe exercise-induced breathlessness
Required a course of antibiotics or oral within the 4 weeks prior to the study commencing
Children with severe co-morbidities that will not allow them to participate in an exercise programme e.g. Severe neuromuscular disorders, recent fractures or surgeries, cognitive or behavioural conditions.
Participant is unable or unwilling, in the opinion of the investigator, to give
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will continue to receive usual care from their asthma team/ provider
Participants will receive a 12 week education class on exercise
Other: education
Participants will take part in a 12 week interval exercise class
Other: EXERCISE TRAINING WITH OR WITHOUT MEDICATION · Other: education
12 week interval exercise training programme and 12 week education on exercise with asthma
Also known as: exercise
education on exercise and asthma
Recruitment
The percentage of children approached who participate in the intervention (recruitment)
Time frame: 12 weeks
Retention
The percentage of participants that complete the intervention with a retention rate of \>70%
Time frame: 12 weeks
Adherence to programme
Participant engagement measured through attendance rates.
Time frame: 12 weeks
Wrist worn accelerometers
Device wear time compliance during the 12-week study, aiming for =\>10 hours a day
Time frame: 12 weeks
Focus groups on patients experience to barriers to an exercise programme
Lived experience of the barriers for children with asthma to taking part in an exercise programme, measured through qualitative focus groups.
Time frame: 12 weeks
Health beliefs
Baseline demographics from participants will be recorded from medical records
Time frame: 12 weeks
Respiratory (throat) samples
Throat samples will be taken and microbial analysis for assessing microbial diversity through 16S rRNA sequencing, to provide relative abundance of bacterial groups. A greater bacterial diversity in the respiratory sample is considered a sign of heathier and more resilient microbial community. This could lead to fewer asthma exacerbations and better asthma control.
Time frame: Baseline, 12 weeks, 6 months and 1 year.
Quality of life of participants using the paeditric quality of life inventory (asthma module)
Measured through the paediatric quality of life asthma module to measure how asthma affects the health-related quality of life using 28 items divided into 4 domains, higher scores mean better quality of life and lower scores mean greater asthma-related impairment.
Time frame: Baseline, 12 weeks, 6 months and 1 year
Effectiveness of the programme
Cardiorespiratory fitness (maximal oxygen uptake measured by VO2 max)
Time frame: Baseline, 12 weeks, 6 months and 1 year.
Respiratory (nasal) samples
Nasal samples will be taken and microbial analysis for assessing microbial diversity through 16S rRNA sequencing, to provide relative abundance of bacterial groups. A greater bacterial diversity in the respiratory sample is considered a sign of a heathier and more resilient microbial community. This could lead to fewer asthma exacerbations and better asthma control.
Time frame: Baseline, 12 weeks, 6 months and 1 year.
Gut samples
Stool samples will be taken and microbial analysis for assessing microbial diversity through 16S rRNA sequencing, to provide relative abundance of bacterial groups. A greater bacterial diversity in the stool sample is considered a sign of heathier and more resilient microbial community which could lead to fewer asthma exacerbations and better asthma control.
Time frame: Baseline, 12 weeks, 6 months and 1 year.
Focus groups on motivators for an exercise programme
Lived experience of the motivators for children and young people with asthma to taking part in an exercise programme, measured through qualitative focus groups.
Time frame: 12 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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