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Enrolling by invitationNCT07634614LASUpdated Jun 11, 2026

Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy

An observational study in GERD, sponsored by Prof Urs Zingg. Enrolling by invitation at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-06-11.

Sponsored by Prof Urs Zingg · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
100
Ages
18 Years and older
Sex
All
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Study summary

Patients with gastroesophageal reflux disease (GERD) may present with concomitant gas-related symptom (GRS) such as supragastric or gastric belching, and aerophagia. Identifying these patients is crucial, as their therapeutic pathway differs substantially from that of patients with "pure" reflux disease. Proceeding directly to antireflux surgery in the presence of untreated air-associated symptoms can lead to catastrophic postoperative outcomes. These partly behavioral disorders can often be effectively managed through targeted speech therapy. Following successful therapy, patients may either experience complete resolution of their symptoms or become suitable candidates for surgical treatment of GERD. As of today, there is very scarce literature on this subject.

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Conditions studied

  • GERD
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In context

Gastroesophageal Reflux

1,067 studies on the registry are indexed under Gastroesophageal Reflux; 188 are open to participants now.

This study's planned enrollment of 100 is below the median of 180 across 298 observational studies indexed under Gastroesophageal Reflux.

Browse Gastroesophageal Reflux studies →

Lead sponsor

Prof Urs Zingg is the lead sponsor of 5 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The retrospective patients are identified through the upper gastrointestinal surgery data base of our institution. All patients who meet the inclusion criteria by having received the intervention which is subject to be studied will be contacted and recruited for the study. There is no participant payment or compensation for enrolment in the study.

Eligibility criteria

Inclusion Criteria:

  • Age 18 years and older
  • Initial presentation at our reflux center with reflux symptoms, with or without concomitant air-related symptoms such as belching, bloating, or abdominal distension
  • Confirmed air-related pathology based on characteristic clinical findings and/or diagnostic evidence from impedance, manometry, or videofluoroscopic swallow study (VFSS)
  • Verbal informed consent as documented by the investigator

Exclusion Criteria:

  • Age under 18 years
  • Pregnancy
  • Exclusion of GERD
  • Preoperative presence of a hiatal hernia with migration of >20% of stomach in the chest
  • Revisional surgery (after other procedures for reflux or at the hiatus)
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Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
100 participants (estimated)
Patient registry
No
06

What researchers measure

Primary outcomes

  1. Comparison of air-associated symptoms and their impact on daily life before and after targeted speech and language therapy in patients with GERD, assessed using a specifically developed patient questionnaire.

    Comparison of air-associated symptoms and their impact on daily life before and after targeted speech and language therapy in patients with GERD.

    Time frame: From start of speech therapy until interview: - Speech therapy was started earliest in January 2023, latest around January 2026. - Interviews are taking place starting in April 2026 until all have been performed, end is anticipated in fall 2026.

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Study locations

1 site
  • Spital Limmattal
    Schlieren, Canton of Zurich 8952, Switzerland
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 11, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07634614
Lead sponsor
Prof Urs Zingg
Responsible party
Prof Urs Zingg (Head, Departement of Operative Disciplines, Spital Limmattal Schlieren) — Sponsor-investigator
First posted
Jun 9, 2026
Start date
Apr 21, 2026
Primary completion
Dec 31, 2027 (estimated)
Completion
Dec 31, 2027 (estimated)
Last update
Jun 11, 2026

Study contacts

Urs Zingg, Prof. Dr. med-
principal investigator · Spital Limmattal Schlieren

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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