An interventional study of Aerobic and resistance exercise in Sedentary Behavior, sponsored by Inonu University. Enrolling by invitation at 1 site in Turkey (Türkiye). Open to female participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-31.
Sponsored by Inonu University · Not applicable, Interventional, and Prevention
Six-week exercise interventions in sedentary young women demonstrated that aerobic exercise and resistance exercise differentially optimize inflammatory and immune responses through their effects on osteocalcin and IgM, and IgA, respectively. These distinct effects of exercise modality on immune biomarkers can be utilized to design personalized exercise programs.
The effects of exercise on the immune system have been studied for many years. Regular physical activity is known to enhance the effectiveness of the immune system by modulating the inflammatory response. Regular exercise has been shown to increase individuals' physical fitness levels. Exercise is used in the prevention and treatment of various diseases. Consequently, a review of the literature reveals numerous studies indicating that regular exercise positively impacts an individual's health. Regular exercise positively affects all systems of the organism, including the immune system. Changes in the immune system after acute and chronic exercise differ. The effects of exercise on the immune system vary depending on the intensity of the exercise and the physical characteristics of the individuals. While light to moderate exercise strengthens the immune system, intense exercise can suppress it. The effects of exercise on the immune system have been the subject of much research in recent years. However, the effects of different types of exercise (aerobic and resistance training) on immune markers are still not fully understood. Inflammatory markers, particularly C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), play a critical role in assessing the effect of exercise on the immune system. In addition, immunoglobulins (IgA, IgG, IgM) are important biomarkers in evaluating the immune response. This study aims to investigate the chronic effects of a 4-week aerobic and resistance exercise program on the immune system and inflammation. Blood and saliva samples will be collected and analyzed for CRP, IL-6, TNF-α, and immunoglobulin levels. The data obtained will help us understand the specific effects of different types of exercise on inflammatory and immune responses, contributing to more informed exercise prescriptions.
1,273 studies on the registry are indexed under Sedentary Behavior; 300 are open to participants now.
This study's planned enrollment of 36 is below the median of 60 across 1,076 interventional studies indexed under Sedentary Behavior.
Browse Sedentary Behavior studies →Inonu University is the lead sponsor of 394 studies on the registry; 95 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Exercise group completed a 6-week supervised training program consisting of three sessions per week on non-consecutive days. Each session lasted 45-60 minutes and included a standardized warm-up, main exercise phase, and cool-down. Training stimulus was controlled using both internal and external load parameters. Internal load was monitored via heart rate (HR) and rating of perceived exertion (RPE), whereas external load was defined by exercise duration, intensity, and training volume.
Behavioral: Aerobic and resistance exercise
The aerobic training group performed continuous exercise on a treadmill or cycle ergometer at 60-75% of heart rate reserve (HRR), corresponding to moderate-to-vigorous intensity. Exercise intensity was continuously monitored using HR and verified with RPE (target: 12-15). A progressive overload approach was applied, with intensity increasing from 60% HRR in the initial weeks to 70-75% HRR in the final phase.
Behavioral: Aerobic and resistance exercise
The control group maintained habitual activities and refrained from structured exercise.
Behavioral: Aerobic and resistance exercise
Because it was done on young girls who lead a sedentary lifestyle.
Change in C-Reactive Protein (CRP) Levels
Serum C-reactive protein levels will be measured using an ELISA kit to evaluate systemic inflammation. (Unit of measurement: mg/L)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Change in Interleukin-6 (IL-6) Levels
Serum interleukin-6 levels will be analyzed to assess pro-inflammatory cytokine response. (Unit of measurement: pg/mL)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Change in Tumor Necrosis Factor-Alpha (TNF-α) Levels
Serum tumor necrosis factor-alpha levels will be measured to evaluate pro-inflammatory cytokine activity. (Unit of measurement: pg/mL)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Change in Salivary Immunoglobulin A (IgA) Levels
Salivary Immunoglobulin A levels will be measured to evaluate mucosal immune response. (Unit of measurement: mg/dL)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Change in Immunoglobulin M (IgM) Levels
Serum Immunoglobulin M levels will be measured to assess acute infection and humoral immune response. (Unit of measurement: mg/dL)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Change in Immunoglobulin G (IgG) Levels
Serum Immunoglobulin G levels will be measured to assess long-term immune memory and humoral immune response. (Unit of measurement: mg/dL)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Change in Leukocyte (WBC) Count
Total leukocyte (White Blood Cell) count will be analyzed to assess general immune and inflammatory status. (Unit of measurement: cells/µL)
Time frame: Baseline (Week 0) and Post-intervention (Week 6)
Plan to share: No
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