An observational study in Post Induction Hypotension, sponsored by Peking Union Medical College Hospital. Recruiting at 1 site in China. Open to participants aged 65 Years and older. Per ClinicalTrials.gov, last updated 2026-06-01.
Sponsored by Peking Union Medical College Hospital · Observational
The purpose of this study is to develop a high-performance machine learning model combining dynamic baroreflex sensitivity (BRS) metrics and multi-dimensional static clinical features to predict the risk of post-induction hypotension (PIH) in elderly patients undergoing elective non-cardiac surgery under general anesthesia.
Aging significantly alters cardiovascular autonomic function, characterized by elevated sympathetic and decreased parasympathetic tone, rendering elderly patients highly vulnerable to post-induction hypotension (PIH). While existing machine learning models heavily rely on static data (e.g., baseline blood pressure, demographics, medication history), they lack real-time dynamic regulatory inputs, limiting their predictive performance in individualized care.
This single-center, prospective cohort study aims to bridge this gap by introducing preoperative BRS parameters-calculated via the continuous non-invasive arterial pressure (CNAP) method-into machine learning frameworks. A total of 500 patients aged over 65 years scheduled for elective non-cardiac surgery will be enrolled. Preoperative data, including autonomic indices, frailty assessments, and static clinical factors, will be mapped alongside intraoperative events and 30-day postoperative complications. Multiple machine learning algorithms (Logistic Regression, Random Forest, GBDT, XGBoost, LightGBM, and LSTM) will be leveraged and optimized using cross-validation to construct a robust clinical decision-support pipeline.
Peking Union Medical College Hospital is the lead sponsor of 1,115 studies on the registry; 463 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients scheduled for elective operations
Exclusion Criteria:
Patients aged over 65 years who are undergoing elective non-cardiac surgery under general anesthesia with endotracheal intubation. All patients will receive continuous non-invasive hemodynamic monitoring prior to anesthesia induction to calculate baseline BRS parameters.
Incidence of Post-Induction Hypotension (PIH)
Defined as a systolic blood pressure (SBP) \<90 mmHg , a mean arterial pressure (MAP) \<65 mmHg, or a decrease in MAP exceeding 30% from baseline measurements.
Time frame: From immediately after anesthesia induction up to 20 minutes post-induction or before surgical incision.
1. Early Intraoperative Hypotension Rate
Defined as a systolic blood pressure (SBP) \<90 mmHg , a mean arterial pressure (MAP) \<65 mmHg, or a decrease in MAP exceeding 30% from baseline measurements.
Time frame: From surgical incision to the end of the operation.
Postoperative Complication
Time frame: Up to 30 days post-surgery
Plan to share: Undecided
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Peking Union Medical College Hospital