Personalize (Signature Driven) Neoadjuvant Chemotherapy Trial for Patients With Resectable Borderline Pancreatic Ductal Adenocarcinoma.

• Borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC) defined by National Comprehensive Cancer Network (NCCN) criteria v2.2025 on contrast-enhanced CT-scan (including non-contrast acquisition, pancreatic phase and portal venous phase), with stage confirmed by a local pancreatic expert review board including at least medical oncologist/onco-gastroenterologist, pancreatic surgeon and pancreatic expert radiologist. No central review is required,
• Measurable pancreatic lesion according to RECIST 1.1 (CT scan or MRI \< 28 days),
• WHO PS 1 or 0,
• Histologically proven pancreas ductal adenocarcinoma,
• Available FFPE from pancreatic tumor sample with > 10% of tumor cells (assessed by a local expert pancreatic pathologist),
• No prior chemotherapy or radiation for pancreatic cancer (except one cycle of mFOLFIRINOX during waiting time for GEM + signature) or resection of pancreatic cancer,
• Age ≥18 years old and ≤ 80 years old if geriatric standardized evaluation validates the study chemotherapy regimen administration for patients between 75-80,
• Written informed consent obtained from patient before any protocol related intervention,
• Acceptation and ability to conform to the protocol requirement during all the duration of the investigation including treatment, scheduled visits, clinical and biological examinations and follow up,
• Adequate organ function, as defined by the following:
• AST and ALT \< 3.5 x upper limit of normal (ULN),
• Total serum bilirubin \< 3 x ULN, (for patients with total serum bilirubin between 1.5 and 3 x ULN, the dose of irinotecan will be adjusted in accordance with the SmPC).
• Serum albumin >30 g/L,
• Hemoglobin >9.0 g/dl,
• Absolute neutrophil count (ANC) >1.5 G/L,
• Platelets >100 G/L,
• Creatinine clearance > 50 mL/min (according to CKD-EPI),
• Normal Kalemia, calcemia, magnesemia
• Women of childbearing potential must agree to use contraception during treatment and for at least 15 months after discontinuation of the experimental treatments. Men who have sexual relationship with women of childbearing potential must agree to use contraception during treatment and for at least 12 months after discontinuation of the experimental treatments.
• Patient affiliated to French social security

Exclusion Criteria:

• Strictly resectable or locally advanced PDAC according to NCCN criteria,
• Distant metastases (including inter aortic lymph nodes),
• Any condition that contraindicates the use of IRINOTECAN, OXALIPLATIN, 5FU, GEMCITABINE or NAB-PACLITAXEL,
• Partial or complete DPD deficiency (uracilemia ≥ 16 ng/mL),
• Any progressive pathology not stabilized over the past 6 months: liver impairment, renal impairment, respiratory or cardiac failure.
• Other concomitant cancer or a history of cancer during the previous 3 years, except for localized cancer in situ, basal or squamous cell skin cancer adequately treated,
• Other interventional clinical trial except for non-interventional trial (ie not modifying 1-year EFS),
• QT/QTc (Fredericia Correction) interval > 450 msec for men and > 460 msec for women,
• Pregnant or breastfeeding woman,
• Known Gilbert's syndrome or known homozygosity for UGAT1A1*28 polymorphism,
• Treatment with millepertuis,
• Uncompensated asthma,
• Potentially severe infection \< 7 days,
• Inflammatory bowel disease and/or intestinal obstruction,
• Known severe allergy to contrast dye (for CT or MRI) without possible substitution,
• Hypersensitivity to the active substance or to one of the excipients of one of the study treatments,
• Treatment with brivudine within 4 weeks prior to the administration of protocol treatment,
• Concomitant treatment with a strong inhibitor (i.e. ketoconazole) or inducer (i.e. rifampicin, carbamazepine, phenobarbital, phenytoin, apalutamide) of cytochrome P450 3A4 or 2C8 (CYP3A4 or CYP2C8),
• Patient who has received a live attenuated vaccine (against yellow fever, chickenpox, shingles, measles, mumps, rubella, tuberculosis, rotavirus) in the 6 weeks prior to randomization,
• Patient with sensitive peripheral neuropathy with functional discomfort,
• Impossibility of undergoing medical monitoring during the trial for geographical, social, or psychological reasons,
• Patient who is under judicial protection (patient who is legally institutionalized or under guardianship or curatorship) or not able to give consent. (as refered at art. art. L. 1121-6, art. L. 1121-8, art. L. 1121-8-1 du Code de la Santé Publique)