An interventional study of membrane sweeping and Routine Vaginal examination in Term Pregnancy, Labour Induction and Delayed Onset of Labour, sponsored by Kharadar General Hospital. Completed at 1 site in Pakistan. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-05-29.
Sponsored by Kharadar General Hospital · Not applicable, Interventional, and Treatment
The goal of this clinical trial is to learn whether membrane sweeping can help start labour naturally and improve delivery outcomes in women with term pregnancy. Membrane sweeping is a simple procedure performed during a vaginal examination in which a healthcare provider gently separates the membranes around the baby from the lower part of the uterus. This may help the body release natural hormones that encourage labour to begin.
This study will include pregnant women aged 18 to 45 years with uncomplicated singleton pregnancies between 38 and 41 weeks of gestation. The main questions this study aims to answer are:
Researchers will compare women who undergo membrane sweeping with women who receive routine care without membrane sweeping to determine whether the procedure improves labour and delivery outcomes.
Participants in the membrane sweeping group will undergo membrane sweeping during routine vaginal examination from 38 weeks of pregnancy until labour starts or until 41 weeks of gestation. Participants in the control group will receive routine antenatal and obstetric care without membrane sweeping. Researchers will record the onset of labour, duration of labour, mode of delivery, and maternal and newborn complications during and after delivery.
Labour induction is one of the most common interventions performed in obstetric practice, particularly in women with prolonged or post-term pregnancy. Delayed onset of labour at term pregnancy may increase the risk of maternal and neonatal complications, including cesarean section, fetal distress, meconium-stained amniotic fluid, and neonatal intensive care unit (NICU) admission. Membrane sweeping is a simple mechanical technique that may help stimulate the natural onset of labour by promoting the release of endogenous prostaglandins and enhancing cervical ripening.
This randomized controlled trial will be conducted at the Department of Obstetrics and Gynaecology, Kharadar General Hospital, Karachi. The study will aim to evaluate the effectiveness and safety of membrane sweeping in women with uncomplicated term pregnancy between 38 and 41 weeks of gestation.
A total of 214 pregnant women aged 18 to 45 years with singleton pregnancies and cephalic presentation will be enrolled in the study. Participants will be allocated into two groups. Women in the intervention group will undergo membrane sweeping during routine vaginal examination, while women in the control group will receive routine obstetric care without membrane sweeping.
Membrane sweeping will be performed by the attending obstetrician by inserting one or two gloved fingers through the cervix and gently separating the fetal membranes from the lower uterine segment using a circular sweeping motion. The procedure may be repeated weekly from 38 weeks of gestation until spontaneous labour occurs or until 41 weeks of gestation. Women who do not enter spontaneous labour by 41 weeks may undergo formal induction of labour according to hospital protocol.
The study will assess the duration between intervention and onset of labour, spontaneous onset of labour, need for induction of labour, and mode of delivery. Maternal outcomes including postpartum hemorrhage, premature rupture of membranes, meconium-stained amniotic fluid, and maternal infection will also be evaluated. Neonatal outcomes including low Apgar score, fetal distress, neonatal infection, low birth weight, NICU admission, and neonatal mortality will be recorded.
Data collected during the study will be analyzed to determine whether membrane sweeping is associated with earlier onset of labour, reduced need for induction, lower cesarean section rates, and improved maternal and neonatal outcomes. The findings of this study may help provide evidence regarding the role of membrane sweeping as a safe, low-cost, and effective intervention for management of term pregnancies.
30 studies on the registry are indexed under Pregnancy, Prolonged; 2 are open to participants now.
This study's enrollment of 214 is above the median of 132 across 23 interventional studies indexed under Pregnancy, Prolonged.
Browse Pregnancy, Prolonged studies →Kharadar General Hospital is the lead sponsor of 3 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
participants in this group will undergo membrane sweeping during routine vaginal examination from 38 weeks of gestation until spontaneous labour occur or until 41 weeks of gestation
Procedure: membrane sweeping
participants in this group will receive routine obstetric care and routine vaginal examination without membrane sweeping
Procedure: Routine Vaginal examination
membrane sweeping will be performed by inserting one or two gloved fingers through the cervix and gently separating the fetal membranes from the lower uterine segment using a circular sweeping motion during vaginal examination
Also known as: membrane stripping, Cervical Sweeping, Sweeping of membrane
participants in the control group will receive routine obstetric care and routine vaginal examination without membrane sweeping
spontaneous Onset of Labour
number of participants who achieve spontaneous labour without formal induction
Time frame: 38 to 41 weeks of gestation
Induction of labour
number of participants requiring pharmacological or surgical induction of labour
Time frame: at 41 weeks of gestation
maternal Complication
Assessment of PPH. PROM, meconium stained amniotic fluid and maternal infection
Time frame: During labour and with in 24 hours after delivery
Plan to share: No — individual participant data collected during this study ill not be publicly available
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Kharadar General Hospital