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Not yet recruitingNCT07607015Updated May 26, 2026

CGM Experience, Preferences & Blood Glucose Parameters

An observational study in Diabete Mellitus, Type2diabetes and type1diabetes, sponsored by Getz Pharma. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-26.

Sponsored by Getz Pharma · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
75
Ages
18 Years and older
Sex
All
01

Study summary

This is an open-label, prospective, multicenter observational study designed to evaluate the perceived benefits, device experience, preference, and glucose-related parameters associated with the Instara-1 Continuous Glucose Monitoring device. The study will include patients with diabetes and healthcare professionals. Patients will use Instara- 1 and will be followed up to assess device experience, glucose parameters, and diabetes-related quality of life. Healthcare professionals will evaluate device experience and preference, including comparison with FreeStyle Libre 2.

Read the detailed description

This study aims to assess the real-world experience and perceived benefits of the Instara-1 Continuous Glucose Monitoring system among patients and healthcare professionals.

Patients diagnosed with diabetes will be enrolled after providing written informed consent. Instara-1 sensor placement will be performed at baseline, screening, and patients will be followed at Week 3, Week 6, Week 9, and Week 12 after CGM initiation. Patient assessments will include user experience, perceived benefits, preference, CGM-derived glucose parameters including estimated HbA1c and Time in Range, laboratory parameters including HbA1c, and diabetes-related quality of life using DQoL-13.

Healthcare professionals will participate to assess device-related experience, usability, preference, and comparison of Instara -1 with FreeStyle Libre 2. HCPs will complete the relevant user experience assessment at baseline before sensor insertion and at Week 3 after device use.

The primary outcomes will focus on perceived benefits, device experience, and preference related to CGM use among patients and HCPs. Secondary outcomes will assess changes in glucose-related parameters and diabetes-related quality of life among patients from baseline to the end of the study.

02

Conditions studied

  • Diabete Mellitus
  • Type2diabetes
  • type1diabetes
  • Gestational Diabetes
  • Pre Diabetes

Keywords

  • CGM
  • Glucose monitoring
  • Time in range
  • estimated HbA1c
  • Time above range
  • Time below range
  • Diabetes Quality of life
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Study participants will be selected from diabetes clinics/healthcare facilities all across Pakistan. The patient population will include adults with diabetes mellitus who are eligible for CGM use as per the study protocol. The HCP population will include healthcare professionals involved in diabetes care, including healthy, pre-diabetic, or diabetic individuals, as applicable to the study arm.

Inclusion criteria

  • Subjects to provide written informed consent prior to any study procedures being performed
  • Subjects with age 18 and above both male and female
  • Diagnosed with Diabetes Miletus Type I, Type II and/or GDM
  • Comfortable using smart phone, access to internet along with Bluetooth connectivity throughout the study duration.
  • Subjects (Patients) on oral or injectable anti-diabetic medications, (in case of insulin, patient must be on insulin from last 3 months )
  • Subjects (HCPs) healthy, Pre-diabetes or Diabetes Miletus (any type)

Exclusion criteria

Exclusion Criteria:

  • History of hypersensitivity to any of the active or inactive ingredients of the CGM device used in the trial, and/or history of significant allergic skin reactions.
  • Presence of severe diabetes complications e.g. retinopathy, acute metabolic crisis, etc.
  • History of active/ acute renal and/or hepatic failure.
  • Patients who have been admitted to the hospital in the past 3 months for diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state.
  • History of critical illness or incapacitated patients
  • History of acute psychiatric disorder or exacerbation of chronic psychiatric disorder.
  • History or presence of a medical condition or disease that in the investigator's opinion would embarrass glycemic control and completion of the study.
  • Medical conditions that require patients to undergo frequent radiation/ imaging procedures for example CT, MRI and X rays
  • History of known hematological disorders such as Sickle Cell Disease \& Trait, Thalassemia, Hemolytic Anemias (e.g., G6PD deficiency, autoimmune), Iron Deficiency Anemia
  • Patients on high doses of acetaminophen (>1 gram every 6 hours), ascorbic acid supplements (e.g., > 500-1000 mg/day), IV sorbitol, steroids and aspirin which can alter the readings on the CGM device.
04

Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
75 participants (estimated)
Target follow-up
3 Months
Patient registry
Yes

Groups and cohorts

  • Instara-1 CGM

    Participants in this arm will use the Instara-1 Continuous Glucose Monitoring . Patients will be followed for device experience, perceived benefits, preference, glucose-related parameters, and diabetes-related quality of life. Healthcare professionals will assess device experience and preference, including comparison with FreeStyle Libre 2 where applicable.

    Device: CGM

Interventions

  • DeviceCGM

    Comparison of 2 devices by HCP

05

What researchers measure

Primary outcomes

  1. Benefit, device experience and preference of continuous glucose monitoring by patients and HCPs

    A user experience questionnaire will be used to assesses how glucose monitoring helps in overall diabetes management, including understanding the effect of food, exercise, and stress on glucose levels, recognizing glucose trends, improving self-management and decision-making, increasing confidence and safety, supporting better communication with healthcare providers improving overall quality of life with diabetes. A 5 point Likert scale will be used to translate subjective experience into structured, comparable feedback

    Time frame: From enrollment to the end of treatment at 3 weeks.

  2. Sensor and mobile application experience of continuous glucose monitoring by patient and comparison with Free Style®Libre 2

    The study will use an evaluation Questionnaire focusing on the usability of the sensor and mobile app. To capture functional experience, behavioral and emotional impact a 5 point Likert scale will be used to translate subjective experience into structured, comparable feedback with 1 being strongly disagree and 5 being strongly agree. The questionnaire will include questions regarding, comfort of wearing the sensor, interference with daily life, pain or inconvenience, perceived reliability of glucose readings, system performance throughout use, overall user friendliness and willingness to use sensor again or recommend it to others.

    Time frame: From the time of enrollment to end of week 3.

Secondary outcomes

  1. eHbA1c%

    Time frame: At week1, week 3, week 6, week 9 and week 12

  2. Time in range (TIR), time above range (TAR) and time below range (TBR) .

    Time frame: Week 1, week 3 , week 6, week 9 and week 12

  3. Mean difference in HbA1c% from laboratory

    Time frame: Baseline and at week 12

  4. Mean difference in Quality of Life (DQoL 13)

    Time frame: At baseline, week 6 and week 12

06

Study locations

No study locations are listed for this record.

07

References and documents

08

Registry details

Key details

Study ID
NCT07607015
Lead sponsor
Getz Pharma
Collaborators
Peshawar General Hospital
Responsible party
Sponsor
First posted
May 26, 2026
Start date
Sep 10, 2026 (estimated)
Primary completion
Aug 10, 2027 (estimated)
Completion
Aug 10, 2027 (estimated)
Last update
May 26, 2026

Study contacts

Jahanzeb Kamal Khan, MCPS
Contact
jahanzeb.kamal@getzpharma.com
+923201212945
Nauman Muhammad Sheikh, MBBS
Contact
nauman.shaikh@getzpharma.com
+923201212981
Jahanzeb Kamal Khan, MCPS
study director · CPSP

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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