An interventional study of 650 nm Photobiomodulation Therapy and 976 nm Photobiomodulation Therapy in Orthodontic Treatment Acceleration and Photobiomodulation Therapy, sponsored by Kufa University. Completed at 1 site in Iraq. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by Kufa University · Not applicable, Interventional, and Treatment
movement using low-level laser therapy with different wavelengths. Participants will receive laser application during orthodontic treatment, and the rate of canine movement will be measured and compared between the study groups. The results may help determine whether low-level laser therapy can accelerate orthodontic tooth movement safely and effectively.
Photobiomodulation therapy (PBMT) has been proposed as a non-invasive adjunctive method to accelerate orthodontic tooth movement and reduce overall treatment duration. This split-mouth randomized clinical trial aims to evaluate and compare the effectiveness of two different laser wavelengths (650 nm and 976 nm) on the acceleration of maxillary canine movement during orthodontic treatment.
Participants requiring bilateral maxillary first premolar extraction and canine retraction as part of their orthodontic treatment will be included. Each patient will serve as their own control using a split-mouth design. One side will receive PBMT application during canine retraction, while the contralateral side will act as the control or receive an alternative wavelength according to the randomization protocol.
Orthodontic canine movement will be performed using standardized orthodontic mechanics under controlled force application. The primary outcome measure will be the rate of maxillary canine movement assessed at regular intervals. Secondary outcomes will include total treatment duration required for space closure and the influence of patient-related factors such as age and gender on treatment outcomes.
The study will compare the clinical effectiveness of 650 nm and 976 nm wavelengths in accelerating orthodontic tooth movement. Statistical analyses including paired t-tests, independent t-tests, and correlation analyses will be used to evaluate differences between groups and assess associations between demographic variables and treatment response.
The findings of this study may provide clinically relevant evidence regarding the effectiveness of PBMT in reducing orthodontic treatment time and improving treatment efficiency.
Kufa University is the lead sponsor of 14 studies on the registry; 3 are open to participants now.
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Exclusion Criteria:
Participants receive photobiomodulation therapy using a 650 nm laser during maxillary canine retraction.
Device: 650 nm Photobiomodulation Therapy
Participants receive photobiomodulation therapy using a 976 nm laser during maxillary canine retraction.
Device: 976 nm Photobiomodulation Therapy
Application of 650 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.
Application of 976 nm low-level laser therapy during maxillary canine retraction to accelerate orthodontic tooth movement.
Rate of Maxillary Canine Movement
Measurement of the amount of maxillary canine movement during orthodontic retraction following application of photobiomodulation therapy using 650 nm and 976 nm wavelengths.
Time frame: 6 months
Correlation Between Age and Rate of Canine Retraction
Assessment of the correlation between patient age (years) and rate of maxillary canine retraction measured in millimeters per month using digital caliper measurements on study models.
Time frame: 6 months
Difference in Rate of Canine Retraction Between Sexes
Comparison of the rate of maxillary canine retraction (mm/month) between male and female participants measured using digital caliper measurements on study models.
Time frame: 6 months
Plan to share: No — Individual participant data will not be publicly shared in order to protect participant confidentiality and privacy.
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Kufa University