An interventional study of Dexmeditomidine and Normal Saline (0.9% Sodium Chloride) in HEMODYNAMIC RESPONSETO LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION, sponsored by Shaheed Mohtarma Benazir Bhutto Institue of Trauma. Active, not recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by Shaheed Mohtarma Benazir Bhutto Institue of Trauma · Not applicable, Interventional, and Treatment
BLUNTING OF HEMODYNAMIC RESPONSE WILL BE OBSERVED IN PATIENTS NEBULISED WITH DEXMEDETOMIDINE AND NORMAL SALINE.
ONE GROUP OF PTS WILL BE NEBULISED WITH DEXMEDETOMIDINE AND OTHER WITH NORMAL SALINE AND WILL BE OBSERVED DURING AND AFTER INTUBATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE FOR LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION
Shaheed Mohtarma Benazir Bhutto Institue of Trauma is the lead sponsor of 12 studies on the registry; 8 are open to participants now.
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participants will receive nebulised dexmedetomidine 1 microgram/kg diluted in 5ml normal saline via nebulised over 5 minutes, administered 30 minutes before induction of anesthesia. standard monitoring of hemodynamic parameters will be done at baseline, 1 minute and 3 minutes post-intubation
Drug: Dexmeditomidine
participants will receive nebulised 5ml normal saline via nebulised over 5 minutes, administered 30 minutes before induction of anesthesia. standard monitoring of hemodynamic parameters will be done at baseline, 1 minute and 3 minutes post-intubation.
Drug: Normal Saline (0.9% Sodium Chloride)
dexmeditomidine 1mcg/kg diluted in 5ml 0.9% sodium chloride, administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction .
normal saline 5 ml administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction.
change in mean artirial pressure and heart rate after lyrangoscopy and intubation
hemodynamic stress response measured as change in mean arterial pressure and heart rate from baseline. MAP and HR will be recorded at baseline T0, 1 minute post intubation T1 ans 3 minute post intubation T3. Significant stress response is defined as rise in MAP nad HR more than 10% of baseline at 3 minutes post intubation.
Time frame: baseline, 1 minute and 3 minute post intubation
Plan to share: No — Individual participant data will not be shared publicly to protect participant confidentiality and privacy as per institutional ethics committee guidelines and informed consent obtained from participants. Data may be shared upon reasonable request to the principal investigator, subject to approval by the institutional ethics committee and execution of a data sharing agreement.
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This study is active, not recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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Shaheed Mohtarma Benazir Bhutto Institue of Trauma