An interventional study of Resistance Exercise and Dietary Intervention in Heart Failure With Reduced Ejection Fraction, sponsored by Medical University of Silesia. Recruiting at 1 site in Poland. Open to participants aged 30 Years and older. Per ClinicalTrials.gov, last updated 2026-05-19.
Sponsored by Medical University of Silesia · Not applicable, Interventional, and Prevention
Heart failure with reduced ejection fraction (HFrEF) is frequently associated with abnormalities in body composition, including reduced skeletal muscle mass and sarcopenia, which are independent predictors of reduced exercise tolerance, impaired quality of life, and increased mortality. Despite advances in pharmacological therapy, evidence-based non-pharmacological strategies aimed at preventing muscle mass loss remain limited.
This randomized controlled trial aims to evaluate the effects of dietary intervention based on the DASH diet with high-protein elements, resistance exercise training, and their combination on skeletal muscle mass, functional capacity, echocardiographic parameters, biochemical markers, and quality of life in patients with HFrEF.
Written informed consent obtained prior to participation Age >30 years Diagnosis of chronic heart failure, NYHA functional class I-III Left ventricular ejection fraction \<40%
Exclusion Criteria:
NYHA functional class IV heart failure Potentially reversible cause of heart failure Estimated glomerular filtration rate \<30 mL/min Severe anemia (hemoglobin \<9 g/dL) Uncontrolled thyroid disease Severe hepatic dysfunction History of hyperkalemia or hyperkalemia at baseline Epilepsy Presence of joint endoprostheses Gastrointestinal disorders limiting adherence to the DASH diet Physical limitations precluding participation in structured exercis
Elastic resistance bands and structured exercise education provided by a medical rehabilitation specialist.
Behavioral: Resistance Exercise
Individualized 14-day meal plan based on the DASH diet with high-protein components.
Behavioral: Dietary Intervention
Combination of dietary counseling and resistance exercise training as described above.
Behavioral: Resistance Exercise · Behavioral: Dietary Intervention
The exercise intervention includes resistance training using elastic bands, with instruction and follow-up provided by a medical rehabilitation specialist.
Individualized 14-day meal plan based on the DASH diet with high-protein components.
Change in skeletal muscle mass
Quantitative assessment of skeletal muscle mass change over the study period.
Time frame: Baseline to 6 months
Change in quality of life
Assessed using the Minnesota Living With Heart Failure Questionnaire.
Time frame: Baseline to 6 months
Change in exercise capacity
Assessed by the 6-minute walk test.
Time frame: Baseline to 6 months
Change in echocardiographic parameters of diastolic function
Changes in left ventricular diastolic function assessed by transthoracic echocardiography, including early transmitral inflow velocity (E), the ratio of early to late transmitral inflow velocities (E/A), and early diastolic mitral annular velocity (e').
Time frame: Baseline to 6 months
Change in laboratory biomarkers
Includes NT-proBNP, HbA1c, K+ creatine, triglycerides, cholesterol,
Time frame: Baseline to 6 months
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Medical University of Silesia