An interventional study of naslacrimal duct probing in Lacrimal Duct Obstruction, sponsored by Hany Mahmoud,MD. Not yet recruiting. Open to participants aged 1 Day to 12 Months. Per ClinicalTrials.gov, last updated 2026-05-18.
Sponsored by Hany Mahmoud,MD · Not applicable, Interventional, and Treatment
This study aims to provide evidence on the optimal timing and efficacy of lacrimal probing in infants with congenital NLDO to minimize morbidity and healthcare costs .
Congenital nasolacrimal duct obstruction (CNLDO) manifests with symptoms such as excessive tearing, lash crusting, and mucopurulent secretions. A significant cohort study revealed that CNLDO affects one in nine newborns, highighting its public health significance 1.
Controversies per-sist regarding the most appropriate time and type of intervention for managing CNLDO2 .
Standard early management typically includes hydrostatic lacrimal sac massage combined with topical antibiotics. Many ophthalmologists believe that a majority of obstructions resolve spontaneously with massage; however, around 25% of children may require additional intervention such as probing 3.
Currently, there is no established consensus on the optimal timing for intervention in theses cases. Because of the possibility of spontaneous resolution, some authors recommend postponing probing until after one year of age . Conversely, other studies suggest that delaying probing beyond six months may increase the risk of inflammation and fibrosis, potentially lowering the success rates of later interventions 4.
Aim of the study This study aims to provide evidence on the optimal timing and efficacy of lacrimal probing in infants with congenital NLDO to minimize morbidity and healthcare costs .
41 studies on the registry are indexed under Lacrimal Duct Obstruction; 8 are open to participants now.
This study's planned enrollment of 50 is below the median of 75 across 30 interventional studies indexed under Lacrimal Duct Obstruction.
Browse Lacrimal Duct Obstruction studies →This is the only study on the registry with Hany Mahmoud,MD as lead sponsor.
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Exclusion Criteria:
patients with congenital nasolacrimal duct obstruction will undergo early probing
Procedure: naslacrimal duct probing
patients with congenital nasolacrimal duct obstruction will undergo lacrimal massage
nasolacrimal duct probing
epiphora stop evaluated by Munk scale and TEARS scale
Munk Scale, which ranges from 0 (no tearing) to 5 (constant tearing) based on daily wiping frequency. TEARS Scale, which measures four subscales: Times of wiping, Effects (clinical), Activity limitations, and Reflex tearing.
Time frame: 3 months
No study locations are listed for this record.
Plan to share: Yes — data are available upon request
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: 3 months
Access criteria: all
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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