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CompletedNCT07590128Updated May 15, 2026

Combined Physical Therapy and Hold-Relax Technique for Adolescent Osgood-Schlatter Knee Pain

An interventional study of Hold-Relax Proprioceptive Neuromuscular Facilitation (PNF) and Progressive Rehabilitation Program in Osgood-Schlatter Disease, sponsored by Benha University. Completed at 1 site in Algeria. Open to male participants aged 14 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-05-15.

Sponsored by Benha University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 4 months after the study started (first participant enrolled Jan 2026, registered May 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
6
Allocation
Not applicable
Ages
14 Years to 18 Years
Sex
Male
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Study summary

This pilot study evaluates the preliminary effectiveness of a combined rehabilitation program incorporating hold-relax (H-R) stretching techniques and progressive therapeutic exercises on knee pain and range of motion (ROM) in adolescent athletes diagnosed with Osgood-Schlatter disease. Utilizing a retrospective, single-group pre-post design on a cohort of six athletic participants, this study aims to generate preliminary clinical evidence and assess feasibility to inform future larger-scale randomized controlled trials. Participants underwent a structured, multi-week rehabilitation protocol, with primary clinical outcomes assessed before and after the intervention period using validated measures of pain intensity and knee joint mobility.

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Conditions studied

  • Osgood-Schlatter Disease

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03

In context

Osteochondrosis

16 studies on the registry are indexed under Osteochondrosis; 5 are open to participants now.

This study's enrollment of 6 is below the median of 51 across 13 interventional studies indexed under Osteochondrosis.

Browse Osteochondrosis studies →

Lead sponsor

Benha University is the lead sponsor of 362 studies on the registry; 66 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
14 Years to 18 Years
Sexes eligible
Male
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Clinical diagnosis of Osgood-Schlatter disease
  • Presence of anterior knee pain localized at the tibial tuberosity
  • Regular participation in sports involving running and jumping
  • No participation in structured rehabilitation programs within the previous 3 months

Exclusion criteria

Exclusion Criteria:

  • History of knee surgery or major trauma
  • Presence of other knee pathologies (e.g., ligament or meniscal injuries)
  • Neurological or systemic disorders affecting movement
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
6 participants (actual)

Study arms

  • Active comparator
    Combined Rehabilitation and Hold-Relax Cohort

    A single experimental group of adolescent athletes diagnosed with Osgood-Schlatter Disease (OSD). All participants in this cohort receive a structured, multi-week progressive rehabilitation program combined with Hold-Relax (H-R) proprioceptive neuromuscular facilitation (PNF) stretching techniques. The intervention protocol consists of: * Hold-Relax stretching targeting the quadriceps and hamstring muscle groups to reduce tensile stress on the tibial tuberosity. * Progressive therapeutic exercises focusing on lower extremity strengthening, load tolerance, and functional biomechanics.

    Behavioral: Hold-Relax Proprioceptive Neuromuscular Facilitation (PNF) · Behavioral: Progressive Rehabilitation Program

Interventions

  • BehavioralHold-Relax Proprioceptive Neuromuscular Facilitation (PNF)

    A target-specific, manual stretching technique administered by a physical therapist to address muscular tightness in the lower extremity. The protocol focuses on the bilateral quadriceps and hamstring muscle groups to reduce the cumulative tensile traction forces exerted on the tibial tuberosity. For each target muscle group, the procedure is performed as follows: Passive Stretch: The physical therapist moves the joint to the limit of comfortable range of motion (ROM) where mild muscle tightness is felt. Isometric Contraction: The participant performs an active, sub-maximal isometric contraction (approximately 50% of maximum voluntary contraction) against the therapist's manual resistance for 6 to 10 seconds, ensuring no actual joint movement occurs. Relaxation and Deeper Passive Stretch: The participant is instructed to relax completely, and the therapist immediately moves the limb passively into a newly gained, deeper range of motion, holding the stati

  • BehavioralProgressive Rehabilitation Program

    A structured, step-by-step active exercise program designed to build lower-limb load tolerance, correct biomechanical compensations, and stabilize the knee joint complex. The rehabilitation progresses systematically through targeted phases based on individual pain levels and movement quality:Phase 1 (Pain Mitigation and Muscle Activation): Focuses on isometric quadriceps setting, straight leg raises (SLR), gluteal bridging, and ankle/hip mobility exercises to avoid direct loading of the patellar tendon while minimizing disuse atrophy.Phase 2 (Strength and Load Tolerance): Introduces closed-kinetic chain exercises with controlled ranges of motion, including shallow wall sits, leg presses, bilateral squats, and progressive calf raises.Phase 3 (Eccentric and Functional Progression): Focuses on eccentric quadriceps strengthening (e.g., controlled step-downs) and sport-specific functional retraining to prepare the adolescent athlete's patellar tendon and tibial tubercle to absorb high groun

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What researchers measure

Primary outcomes

  1. Change from Baseline in Knee Pain Intensity on the Visual Analog Scale (VAS)

    Knee pain during athletic activity is assessed using a 10-centimeter Visual Analog Scale (VAS). The scale is a horizontal line where 0 centimeters indicates "no pain" and 10 centimeters indicates "the worst possible pain." The outcome is calculated as the change in the pain score (post-intervention score minus baseline score). A negative change indicates an improvement (reduction) in knee pain.

    Time frame: Baseline (Day 1, pre-intervention) and post-intervention (Week 10, immediately following completion of the last rehabilitation session).

Secondary outcomes

  1. Change from Baseline in Active Knee Flexion Range of Motion

    Active knee joint flexion range of motion measured in degrees of joint angle using a standard universal goniometer. The participant lies in a supine position and actively bends the knee as far as possible. The outcome is calculated as the change in degrees from baseline to post-intervention. An increase in degrees indicates an improved range of motion.

    Time frame: Baseline (Day 1, pre-intervention) and post-intervention (Week 10, immediately following completion of the last rehabilitation session).

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Study locations

1 site
  • Batna 2 University
    Batna City, Batna 05078, Algeria
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Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Ran from Jan 2026 to primary completion in Mar 2026, 2 months.

How these figures are worked out, and which studies are left out of them.

Registered
May 11, 2026
First posted
May 15, 2026
StartActual
Jan 2, 2026
Primary completionActual
Mar 30, 2026
CompletionActual
Apr 15, 2026
Last update
May 15, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on May 15, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07590128
Lead sponsor
Benha University
Responsible party
Adel Farag Al Kholy (Professor of Medical Biochemistry, Benha University) — Principal investigator
First posted
May 15, 2026
Start date
Jan 2, 2026
Primary completion
Mar 30, 2026
Completion
Apr 15, 2026
Last update
May 15, 2026

Study contacts

Mahmoud El sayed, Bachelor of Physical Therapy
principal investigator · Benha University
Ahmed Said, Bachelor of Physical Therapy
principal investigator · Benha University

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.

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