An observational study in Delirium - Postoperative and Sleep Problems, sponsored by Yan Fuxia. Recruiting at 1 site in China. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-05-14.
Sponsored by Yan Fuxia · Observational
This study is titled "Metabolomics and Biomarker Research on the Mechanism of Preoperative Sleep Disorders Affecting Postoperative Outcomes in Adult Cardiac Surgery". It aims to clarify the perioperative metabolic changes caused by preoperative sleep disorders in adult cardiac surgery patients, providing ideas for exploring the mechanism by which sleep disorders affect adverse outcomes after cardiac surgery. The study will be conducted at Fuwai Hospital, Chinese Academy of Medical Sciences. By collecting perioperative blood and fecal samples from adult cardiac surgery patients with and without preoperative sleep disorders, and simultaneously recording postoperative clinical outcome indicators (such as the incidence of delirium within 7 days after surgery, cognitive function scores, mechanical ventilation time, ICU stay time, hospital stay time, and severe cardiovascular adverse events), the study will explore the impact of preoperative sleep disorders on perioperative plasma metabolic substances, inflammatory levels, nerve damage, oxidative stress levels, and intestinal flora in adult cardiac surgery patients under general anesthesia, providing ideas and evidence for exploring the mechanism by which preoperative sleep disorders affect postoperative outcomes in adult cardiac surgery patients under general anesthesia.
763 studies on the registry are indexed under Emergence Delirium; 241 are open to participants now.
This study's planned enrollment of 144 is below the median of 164 across 280 observational studies indexed under Emergence Delirium.
Browse Emergence Delirium studies →Yan Fuxia is the lead sponsor of 6 studies on the registry; 6 are open to participants now.
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Adult patients scheduled for elective cardiac surgery
Exclusion Criteria:
Other: This is a observational study and there is no intervention.
This is a observational study and there is no intervention.
Differential changes in plasma metabolic substances during the perioperative period
Time frame: 24 hours before and after the operation
Perioperative inflammatory marker levels
Time frame: 24 hours before and after the surgery
Perioperative nerve injury marker levels
Time frame: 24 hours before and after the surgery
Perioperative oxidative stress marker levels
Time frame: 24 hours before and after the surgery
Characteristics of the intestinal flora before the surgery
Time frame: 24 hours before the surgery
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