An observational study in Unilateral Vocal Cord Paralysis and Vocal Cord Atrophy, sponsored by University of California, San Francisco. Enrolling by invitation at 10 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by University of California, San Francisco · Observational
The goal of this observational study is to learn about the long-term outcomes of Laryngeal Framework Surgery (LFS) in patients with Unilateral Vocal Fold Paralysis (UVFP) or Vocal Fold Atrophy (VFA). The main questions it aims to answer are:
Participants who are determined by their clinician to need LFS for their UVFP or VFA will undergo the procedure, attend follow-up appointments, and complete surveys about their voice and swallowing ability as they would as part of their regular medical care.
55 studies on the registry are indexed under Vocal Cord Paralysis; 14 are open to participants now.
This study's planned enrollment of 500 is above the median of 70 across 15 observational studies indexed under Vocal Cord Paralysis.
Browse Vocal Cord Paralysis studies →University of California, San Francisco is the lead sponsor of 2,132 studies on the registry; 375 are open to participants now.
Of its 262 completed or terminated interventional studies of FDA-regulated products, 196 (75%) have results posted.
Counted across the registry records on this site, refreshed daily.
Potential participants will be identified by treating laryngologists at the lead site (UCSF) or partner sites (Massachusetts Eye and Ear, Wake Forest, University of Cincinnati, UCSD) at the time the patient presents for their visit. If the patient is determined to have UVFP or vocal fold atrophy and is interested in undergoing surgical treatment, they will be asked about their interest in participating.
Exclusion Criteria:
Participants receive Laryngeal Framework Surgery, defined as medialization thyroplasty with or without arytenoid adduction.
Procedure: Laryngeal Framework Surgery
All participants will receive laryngeal framework surgery as recommended by their treating surgeon. This can include medialization thyroplasty with or without arytenoid adduction, under general anesthesia or monitored anesthesia care.
Also known as: medialization thyroplasty, arytenoid adduction
Change from baseline in the mean VHI-10 score at 12-months post operation
Voice Handicap Index-10 is a 10-item questionnaire used to measure voice handicap. Scores range from 0-40 with higher scores indicating greater voice handicap.
Time frame: Baseline and 12 months
Plan to share: No
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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University of California, San Francisco