An interventional study of Plant based diet and Diet based on the recommendations of the European Society of Cardiology in Myocardial Infarction First, sponsored by Radana Dymáčková. Completed at 1 site in Czechia. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-05-08.
Sponsored by Radana Dymáčková · Not applicable, Interventional, and Prevention
The goal of this clinical trial is to evaluate whether short-term dietary interventions can improve cardiometabolic risk factors in patients after myocardial infarction. The study includes adult patients following myocardial infarction.
The main questions it aims to answer are:
Participants will:
This was a single-center, three-arm, controlled, partially randomized interventional pilot study designed to evaluate the feasibility and potential effects of dietary modification in the secondary prevention of myocardial infarction over a three-month period. Participants were recruited between January 2022 and December 2025. The study duration was three months.
Participants who agreed to change their dietary habits were randomized in a 1:1 ratio into two intervention groups using stratified block randomization according to diabetes mellitus status and smoking status. Group A followed a diet based on the recommendations of the European Society of Cardiology (ESC), while Group B adopted a strictly plant-based (vegan) diet.
Patients who declined dietary modification but agreed to undergo study assessments were included as a parallel, non-intervention control group (Group C), based on patient preference.
All participants underwent clinical and laboratory assessments at baseline and at three months, including body composition analysis using bioimpedance (InBody). In the intervention groups, additional scheduled visits were conducted at monthly intervals during the three-month period. At these visits, participants received nutritional counseling from a registered dietitian and completed a three-day dietary record to assess dietary intake and adherence. Participants were additionally allowed to contact the dietitian or the study physician outside the scheduled visits if needed.
Laboratory analyses included lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, lipoprotein(a), triglycerides), glycemic parameters (fasting blood glucose, glycated hemoglobin HbA1c), inflammatory markers (high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6)), vitamin B12, vitamin D, iron metabolism, complete blood count, and basic biochemical parameters.
Patient recruitment was conducted in collaboration with the coronary care unit of St. Anne's University Hospital Brno (FNUSA). Nutritional counselling was delivered by trained Master's degree nutrition therapy students from the Faculty of Medicine, Masaryk University.
2,744 studies on the registry are indexed under Myocardial Infarction; 418 are open to participants now.
This study's enrollment of 24 is below the median of 148 across 1,595 interventional studies indexed under Myocardial Infarction.
Browse Myocardial Infarction studies →This is the only study on the registry with Radana Dymáčková as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
The intervention arm, in which participants switch to a strictly plant-based (vegan) diet for three months.
Other: Plant based diet
The intervention arm, in which participants switch to a diet based on the recommendations of the European Society of Cardiology for three months.
Other: Diet based on the recommendations of the European Society of Cardiology
Patients who declined dietary modification but agreed to undergo study assessments were included as a parallel, non-intervention control group.
Change dietary habits for tree months
Change dietary habits for tree months
Percentage of participants enrolled in the study
In percentage terms, the number of patients contacted and the proportion of those who were subsequently enrolled.
Time frame: 48 months
Percentage of participants completed the study
Percentage of the enrolled patients completed the study.
Time frame: 3 month
Changes in weight after diet changes
Change from baseline InBody - bioelectrical impedance analysis Unit: kg
Time frame: 3 months
Changes in viceral fat area after diet changes
Change from baseline. InBody - bioelectrical impedance analysis Unit: cm3
Time frame: 3 month
Changes in skeletal muscle mass after diet changes
Change from baseline InBody - bioelectrical impedance analysis Unit: kg
Time frame: 3 month
Changes in body fat mass after diet changes
Change in baseline InBody - bioelectrical impedance analysis Unit: kg
Time frame: 3 month
Changes in total body water after diet changes
Change from baseline InBody - bioelectrical impedance analysis Unit: litr
Time frame: 3 month
Changes in body mass index after diet changes
Change from baseline InBody - bioelectrical impedance analysis Unit: kg/m2
Time frame: 3 month
Changes in glycated hemoglobin after diet changes
Change from baseline Blood test Unit: mmol/mol
Time frame: 3 month
Changes in potassium after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in magnesium after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in iron after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in fasting glucose after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in total cholesterol after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in LDL-cholesterol after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in HDL-cholesterol after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in triglycerides after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Changes in lipoprotein(a) after diet changes
Change from baseline Blood test Unit: nmol/l
Time frame: 3 month
Changes in IL-6 after diet changes
Change from baseline Blood test Unit: ng/l
Time frame: 3 month
Changes in hsCRP after diet changes
Change from baseline Blood test Unit: mg/l
Time frame: 3 month
Changes in vitamin B12 after diet changes
Change from baseline Blood test Unit: pmol/l
Time frame: 3 month
Changes in 25-hydroxyvitamin D after diet changes
Change from baseline Blood test Unit: nmol/l
Time frame: 3 month
Changes in ferritin after diet changes
Change from baseline Blood test Unit: ug/l
Time frame: 3 month
Changes in transferin after diet changes
Change from baseline Blood test Unit: g/l
Time frame: 3 month
Changes in hemoglobin after diet changes
Change from baseline Blood test Unit: g/l
Time frame: 3 month
Changes in body fat after diet changes
Change from baseline InBody - bioelectrical impedance analysis Unit: %
Time frame: 3 month
Changes in calcium after diet changes
Change from baseline Blood test Unit: mmol/l
Time frame: 3 month
Plan to share: No — This is a pilot academic study; there is no need to share the IPD with other researchers.
No publications or documents are linked to this record.
This study is completed, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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