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CompletedNCT07576140Updated May 8, 2026

Effects of Mobilization With Movement and Active Release Technique in Patients With Lateral Epicondylitis

An interventional study of MWM+ ART and Conventional therapy group in Lateral Epicondylitis (Tennis Elbow), sponsored by Riphah International University. Completed at 1 site in Pakistan. Open to participants aged 18 Years to 55 Years. Per ClinicalTrials.gov, last updated 2026-05-08.

Sponsored by Riphah International University · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Registered 6 months after the study started (first participant enrolled Nov 2025, registered May 2026).
Phase
Not applicable
Study type
Interventional
Enrollment
44
Allocation
Randomized
Ages
18 Years to 55 Years
Sex
All
01

Study summary

This study is a randomized controlled trial (RCT) investigating the effectiveness of Mobilization with Movement (MWM) combined with Active Release Technique (ART) in the management of lateral epicondylitis. A total of 44 participants, aged 18-55 years with a clinical diagnosis of lateral epicondylitis (duration ≥6 weeks), will be randomly assigned into two groups. The intervention group will receive MWM, applied as sustained lateral glides during active, pain-free movements, along with ART targeting the wrist extensor muscles, with both techniques administered three sessions per week for four weeks in combination with conventional treatment. The control group will receive conventional treatment only. The primary outcome measures will include pain intensity assessed using the Numeric Pain Rating Scale (NPRS), functional disability using the Patient-Rated Tennis Elbow Evaluation (PRTEE), grip strength measured with a hand dynamometer, and range of motion assessed using a goniometer. Assessments will be conducted at baseline, at the end of week 2, and at the end of week 4. The study aims to determine whether the addition of MWM and ART provides significant improvements in pain reduction, correction of joint mechanics, and functional performance compared to conventional therapy alone.

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Conditions studied

  • Lateral Epicondylitis (Tennis Elbow)

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Keywords

  • Lateral Epicondylitis
  • MWM for LE
  • ART
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In context

Tennis Elbow

284 studies on the registry are indexed under Tennis Elbow; 60 are open to participants now.

This study's enrollment of 44 is below the median of 50 across 253 interventional studies indexed under Tennis Elbow.

Browse Tennis Elbow studies →

Lead sponsor

Riphah International University is the lead sponsor of 2,133 studies on the registry; 633 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 55 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Duration of symptoms ≥ 6 weeks. Pain intensity of NPRS ≥ 4 at baseline. Elbow pain during specific tests, i.e., Cozen's Test (resisted wrist extension with the elbow extended) and Mill's Test (passive wrist flexion with the elbow extended). Presence of clinical symptoms such as lateral elbow pain, tenderness over the lateral epicondyle, reduced grip strength, and pain aggravated by wrist extension or gripping activities

Exclusion criteria

Exclusion Criteria:

  • Subjects with pain at the wrist, neck, or shoulder; bilateral elbow pain; previous elbow surgery in the last 12 months; or any arthritic changes of the elbow joint.
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Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Participant)
Enrollment
44 participants (actual)

Study arms

  • Experimental
    Intervention Group

    MWM+ ART+ Conventional therapy

    Other: MWM+ ART

  • Active comparator
    Control Group

    Conventional Therapy for lateral epicondylitis

    Other: Conventional therapy group

Interventions

  • OtherMWM+ ART

    Participants allocated to the experimental group will receive a combined intervention consisting of Mobilization with Movement (MWM), Active Release Technique (ART), and conventional rehabilitation. MWM will be applied as a sustained lateral glide to the elbow joint while the participant performs pain-free active movements such as gripping or wrist extension, aiming to correct joint positional faults and reduce pain. ART will be administered to the wrist extensor muscle group, particularly targeting the extensor carpi radialis brevis, using manual tension combined with active or passive muscle movement to release soft tissue adhesions and improve tissue mobility. Both MWM and ART will be delivered at a frequency of three sessions per week for four weeks. In addition, participants will perform a conventional rehabilitation program including eccentric strengthening exercises for the wrist extensors, stretching exercises, and activity modification advice.

  • OtherConventional therapy group

    Participants allocated to Arm 2 (control group) will receive conventional physiotherapy treatment only for the management of lateral epicondylitis. The treatment protocol will include the application of a hot pack for 15 minutes, placed over the lateral aspect of the elbow to help reduce pain, improve local circulation, and prepare the tissues for exercise. Following this, participants will perform post-treatment dynamic stretching exercises, including dynamic wrist flexor stretches and forearm supination/pronation swings to improve flexibility and mobility of the forearm musculature.This treatment will be administered three sessions per week for four weeks and will serve as the standard care protocol against which the experimental intervention will be compared.

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What researchers measure

Primary outcomes

  1. Numeric Pain rating scale

    Level of pain measured by Numeric Pain rating scale (NPRS), 0 means no pain and 10 means severe pain

    Time frame: From enrollment to the end of treatment at 1 week]

  2. Functional Disability

    Pain and functional disability of tennis elbow patients can be measured using a patient-rated tennis elbow evaluation (PRTEE) questionnaire. The PRTEE consists of 15 questions: Pain has 5 items, Sum of the 5 pain items. Function has 6 items (specific activities) + 4 items (usual activities), Sum of the 10 function items, divided by 2. PRTEE items are graded from 0 to 10, with zero indicating no discomfort or handicap and 10 indicating the worst or unable

    Time frame: From enrollment to the end of treatment at 1 week]

Secondary outcomes

  1. Range of motion

    Range of motion at ankle joint measured using goniometer

    Time frame: From enrollment to the end of treatment at 1 week

07

Study locations

1 site
  • Ali Ahmad Physiocare
    Islamabad, 44010, Pakistan
08

References and documents

Publications

  • Uttamchandani SR, Phansopkar P. Efficacy of PowerBall Versus Mulligan Mobilization With Movement on Pain and Function in Patients With Lateral Epicondylitis: A Randomized Clinical Trial. Cureus. 2024 Mar 19;16(3):e56444. doi: 10.7759/cureus.56444. eCollection 2024 Mar. PubMed 38638770 ↗
  • Reyhan AC, Sindel D, Dereli EE. The effects of Mulligan's mobilization with movement technique in patients with lateral epicondylitis. J Back Musculoskelet Rehabil. 2020;33(1):99-107. doi: 10.3233/BMR-181135. PubMed 31104005 ↗
  • Nagore A, Samal S, Thakre VM. Effectiveness of Active Release Technique With Conventional Therapy in the Management of Lateral Epicondylitis: A Case Report. Cureus. 2023 Dec 21;15(12):e50926. doi: 10.7759/cureus.50926. eCollection 2023 Dec. PubMed 38249180 ↗
  • Tosti R, Jennings J, Sewards JM. Lateral epicondylitis of the elbow. Am J Med. 2013 Apr;126(4):357.e1-6. doi: 10.1016/j.amjmed.2012.09.018. Epub 2013 Feb 8. PubMed 23398951 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 8, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT07576140
Lead sponsor
Riphah International University
Responsible party
Sponsor
First posted
May 8, 2026
Start date
Nov 2, 2025
Primary completion
Apr 22, 2026
Completion
Apr 27, 2026
Last update
May 8, 2026

Study contacts

Sadia Sameen
principal investigator · Riphah International University

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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